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論文
- タイトル
- タイトル（英）
- Excessive excitability of inhibitory cortical circuit and disturbance of ballistic targeting movement in degenerative cerebellar ataxia
- 参照URL
- https://researchmap.jp/TakeruHONDA/published_papers/43215104
- 著者
- 著者（英）
- Akiyoshi Matsugi,Satoru Nishishita,Kyota Bando,Yutaka Kikuchi,Keigo Tsujimoto,Yuto Tanabe,Naoki Yoshida,Hiroaki Tanaka,Shinya Douchi,Takeru Honda,Masato Odagaki,Hideki Nakano,Yohei Okada,Nobuhiko Mori,Koichi Hosomi
- 担当区分
- 概要
- 概要（英）
- Abstract This study aimed to investigate abnormalities in inhibitory cortical excitability and motor control during ballistic-targeting movements in individuals with degenerative cerebellar ataxia (DCA). Sixteen participants took part in the study (DCA group [n = 8] and healthy group [n = 8]). The resting motor-threshold and cortical silent period (cSP) were measured in the right-hand muscle using transcranial magnetic stimulation over the left primary motor cortex. Moreover, the performance of the ballistic-targeting task with right wrist movements was measured. The Scale for the Assessment and Rating of Ataxia was used to evaluate the severity of ataxia. The results indicated that the cSP was significantly longer in participants with DCA compared to that in healthy controls. However, there was no correlation between cSP and severity of ataxia. Furthermore, cSP was linked to the ballistic-targeting task performance in healthy participants but not in participants with DCA. These findings suggest that there is excessive activity in the gamma-aminobutyric acid-mediated cortical inhibitory circuit in individuals with DCA. However, this increase in inhibitory activity not only fails to contribute to the control of ballistic-targeting movement but also shows no correlation with the severity of ataxia. These imply that increased excitability in inhibitory cortical circuits in the DCA may not contribute the motor control as much as it does in healthy older adults under limitations associated with a small sample size. The study's results contribute to our understanding of motor control abnormalities in people with DCA and provide potential evidence for further research in this area.
- 出版者・発行元
- 出版者・発行元（英）
- Springer Science and Business Media LLC
- 誌名
- 誌名（英）
- Scientific Reports
- 巻
- 13
- 号
- 1
- 開始ページ
- 終了ページ
- 出版年月
- 2023年8月25日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1038/s41598-023-41088-3
- 共同研究・競争的資金等の研究課題
研究者
本多 武尊
( )