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論文
- タイトル
- タイトル（英）
- Differential second messenger signaling via dopamine neurons bidirectionally regulates memory retention
- 参照URL
- https://researchmap.jp/mtomo2709/published_papers/43742417
- 著者
- 著者（英）
- Mai Takakura,Yu Hong Lam,Reiko Nakagawa,Man Yung Ng,Xinyue Hu,Priyanshu Bhargava,Abdalla G. Alia,Yuzhe Gu,Zigao Wang,Takeshi Ota,Yoko Kimura,Nao Morimoto,Fumitaka Osakada,Ah Young Lee,Danny Leung,Tomoyuki Miyashita,Juan Du,Hiroyuki Okuno,Yukinori Hirano
- 担当区分
- 概要
- 概要（英）
- Memory formation and forgetting unnecessary memory must be balanced for adaptive animal behavior. While cyclic AMP (cAMP) signaling via dopamine neurons induces memory formation, here we report that cyclic guanine monophosphate (cGMP) signaling via dopamine neurons launches forgetting of unconsolidated memory in Drosophila . Genetic screening and proteomic analyses showed that neural activation induces the complex formation of a histone H3K9 demethylase, Kdm4B, and a GMP synthetase, Bur, which is necessary and sufficient for forgetting unconsolidated memory. Kdm4B/Bur is activated by phosphorylation through NO-dependent cGMP signaling via dopamine neurons, inducing gene expression, including kek2 encoding a presynaptic protein. Accordingly, Kdm4B/Bur activation induced presynaptic changes. Our data demonstrate a link between cGMP signaling and synapses via gene expression in forgetting, suggesting that the opposing functions of memory are orchestrated by distinct signaling via dopamine neurons, which affects synaptic integrity and thus balances animal behavior.
- 出版者・発行元
- 出版者・発行元（英）
- Proceedings of the National Academy of Sciences
- 誌名
- 誌名（英）
- Proceedings of the National Academy of Sciences
- 巻
- 120
- 号
- 36
- 開始ページ
- 終了ページ
- 出版年月
- 2023年8月28日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 0027-8424
- DOI URL
- https://doi.org/10.1073/pnas.2304851120
- 共同研究・競争的資金等の研究課題
研究者
宮下 知之
(ミヤシタ トモユキ)