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論文
- タイトル
- タイトル（英）
- Intranasal HBsAg/HBcAg-Containing Vaccine Induces Neutralizing Anti-HBs Production in Hepatitis B Vaccine Non-Responders.
- 参照URL
- https://researchmap.jp/sanada_tk/published_papers/43618585
- 著者
- 著者（英）
- Kana Shiraishi,Osamu Yoshida,Yusuke Imai,Sheikh Mohammad Fazle Akbar,Takahiro Sanada,Michinori Kohara,Takashi Miyazaki,Taizou Kamishita,Teruki Miyake,Masashi Hirooka,Yoshio Tokumoto,Masanori Abe,Julio Cesar Aguilar Rubido,Gerardo Guillen Nieto,Yoichi Hiasa
- 担当区分
- 概要
- 概要（英）
- Hepatitis B vaccine induces the production of antibodies against hepatitis B surface antigen (anti-HBs) and prevents hepatitis B virus (HBV) infection. However, 5-10% of individuals cannot develop anti-HBs even after multiple vaccinations (HB vaccine non-responders). We developed an intranasal vaccine containing both HBs antigen (HBsAg) and HB core antigen (HBcAg) and mixed it with a viscosity enhancer, carboxyl vinyl polymer (CVP-NASVAC). Here, we investigated the prophylactic capacity of CVP-NASVAC in HB vaccine non-responders. Thirty-four HB vaccine non-responders were administered three doses of intranasal CVP-NASVAC. The prophylactic capacity of CVP-NASVAC was assessed by evaluating the induction of anti-HBs and anti-HBc (IgA and IgG) production, HBV-neutralization activity of sera, and induction of HBs- and HBc-specific cytotoxic T lymphocytes (CTLs). After CVP-NASVAC administration, anti-HBs and anti-HBc production were induced in 31/34 and 27/34 patients, respectively. IgA anti-HBs and anti-HBc titers significantly increased after CVP-NASVAC vaccination. HBV-neutralizing activity in vitro was confirmed in the sera of 26/29 CVP-NASVAC-administered participants. HBs- and HBc-specific CTL counts substantially increased after the CVP-NASVAC administration. Mild adverse events were observed in 9/34 participants; no serious adverse events were reported. Thus, CVP-NASVAC could be a beneficial vaccine for HB vaccine non-responders.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Vaccines
- 巻
- 11
- 号
- 9
- 開始ページ
- 終了ページ
- 出版年月
- 2023年9月12日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.3390/vaccines11091479
- 共同研究・競争的資金等の研究課題
研究者
真田 崇弘
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