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論文
- タイトル
- タイトル（英）
- [Widely Applicable Strategies Against Cancer, Type II Diabetes, and Neurodegenerative Diseases by Means of Rationally Designed Anti-Amyloidogenic Molecules].
- 参照URL
- https://researchmap.jp/ysk_T/published_papers/43820446
- 著者
- 著者（英）
- Yoshiki Takamatsu,Makoto Hashimoto
- 担当区分
- 筆頭著者,責任著者
- 概要
- 概要（英）
- An increasing number of amyloidogenic proteins are being recognized for their contribution to the progression of various diseases, including cancer, type II diabetes, and neurodegenerative diseases. Detailed analyses of amyloids using cryo-electron microscopy have led to the development of rationally designed inhibitors of amyloid protein aggregation. In this review, we focused on widely applicable strategies against multiple amyloidogenic proteins based on the use of engineered molecules, namely peptidomimetic foldamers, steric zipper inhibitory peptides, di-phenyl-pyrazole derivatives, and chemicals involved in the disaggregation of amyloid fibrils. These strategies could facilitate efficient drug design across disease categories.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Brain and nerve = Shinkei kenkyu no shinpo
- 巻
- 75
- 号
- 10
- 開始ページ
- 1143
- 終了ページ
- 1148
- 出版年月
- 2023年10月
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.11477/mf.1416202491
- 共同研究・競争的資金等の研究課題
研究者
高松 芳樹
(タカマツ ヨシキ)