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論文
- タイトル
- タイトル（英）
DNA methylation status ofSHATI /NAT8L promoter in the blood of cigarette smokers- 参照URL
- https://researchmap.jp/daisuke_nishizawa/published_papers/43878495
- 著者
- 著者（英）
- Naotaka Izuo,Hajime Miyanishi,Daisuke Nishizawa,Takuma Fujii,Junko Hasegawa,Naomi Sato,Fumihiko Tanioka,Haruhiko Sugimura,Kazutaka Ikeda,Atsumi Nitta
- 担当区分
- 概要
- 概要（英）
- Abstract Aims Cigarette smoking is a preventable risk factor for various diseases such as cancer, ischemic stroke, cardiac stroke, and chronic obstructive pulmonary disease. Smoking cessation is of great importance not only for individual smokers but also for social health. Regarding current cessation therapies, the effectiveness of nicotine replacement is limited, and the cost of varenicline medication is considerable. Thus, a method for screening smokers who are responsive to cessation therapy based on the therapeutic effectiveness is required. Peripheral biomarkers reflecting smoking dependence status are necessary to establish a method for achieving effective cessation therapy. Methods Methylation status of smokers' blood DNA was evaluated focusing on SHATI/NAT8L, an addiction‐related gene. Eight CpG sites in SHATI/NAT8L were quantified by pyrosequencing. Results There was no difference in the methylation status of this gene between smokers (n = 129) and non‐smokers (n = 129) at all CpG sites. No correlations between the methylation status of SHATI/NAT8L and indicators of smoking dependence were found. Conclusions Although the present study found no significance in the DNA methylation of SHATI/NAT8L among smokers, the exploration of predictable peripheral biomarkers for the effectiveness of smoking cessation therapy is required.
- 出版者・発行元
- 出版者・発行元（英）
- Wiley
- 誌名
- 誌名（英）
- Neuropsychopharmacology Reports
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2023年9月5日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 2574-173X
- DOI URL
- https://doi.org/10.1002/npr2.12373
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