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論文
- タイトル
- タイトル（英）
- Cdc7 kinase is required for postnatal brain development.
- 参照URL
- https://researchmap.jp/Igutomo/published_papers/43896025
- 著者
- 著者（英）
- Karin Hori,Satoshi Yamazaki,Chiaki Ohtaka-Maruyama,Tomio Ono,Tomohiro Iguchi,Hisao Masai
- 担当区分
- 責任著者
- 概要
- 概要（英）
- The evolutionally conserved Cdc7 kinase plays crucial roles in initiation of DNA replication as well as in other chromosomal events. To examine the roles of Cdc7 in brain development, we have generated mice carrying Cdc7 knockout in neural stem cells by using Nestin-Cre. The Cdc7Fl/Fl NestinCre mice were born, but exhibited severe growth retardation and impaired postnatal brain development. These mice exhibited motor dysfunction within 9 days after birth and did not survive for more than 19 days. The cerebral cortical layer formation was impaired, although the cortical cell numbers were not altered in the mutant. In the cerebellum undergoing hypoplasia, granule cells (CGC) decreased in number in Cdc7Fl/F l NestinCre mice compared to the control at E15-18, suggesting that Cdc7 is required for DNA replication and cell proliferation of CGC at mid embryonic stage (before embryonic day 15). On the other hand, the Purkinje cell numbers were not altered but its layer formation was impaired in the mutant. These results indicate differential roles of Cdc7 in DNA replication/cell proliferation in brain. Furthermore, the defects of layer formation suggest a possibility that Cdc7 may play an additional role in cell migration during neural development.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Genes to cells : devoted to molecular & cellular mechanisms
- 巻
- 28
- 号
- 10
- 開始ページ
- 679
- 終了ページ
- 693
- 出版年月
- 2023年10月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1111/gtc.13059
- 共同研究・競争的資金等の研究課題