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論文
- タイトル
- タイトル（英）
- Ultrastructures of α-synuclein filaments in synucleinopathy brains and experimental models.
- 参照URL
- https://researchmap.jp/masatohasegawa/published_papers/44097750
- 著者
- 著者（英）
- Airi Tarutani,Masato Hasegawa
- 担当区分
- 概要
- 概要（英）
- Intracellular α-synuclein (α-syn) inclusions are a neuropathological hallmark of Lewy body disease (LBD) and multiple system atrophy (MSA), both of which are termed synucleinopathy. LBD is defined by Lewy bodies and Lewy neurites in neurons, while MSA displays glial cytoplasmic inclusions in oligodendrocytes. Pathological α-syn adopts an ordered filamentous structure with a 5-10 nm filament diameter, and this conformational change has been suggested to be involved in the disease onset and progression. Synucleinopathy also exhibits characteristic ultrastructural and biochemical properties of α-syn filaments, and α-syn strains with distinct conformations have been identified. Numerous experimental studies have supported the idea that pathological α-syn self-amplifies and spreads throughout the brain, during which processes the conformation of α-syn filaments may drive the disease specificity. In this review, we summarize the ultrastructural features and heterogeneity of α-syn filaments in the brains of patients with synucleinopathy and in experimental models of seeded α-syn aggregation.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Journal of movement disorders
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2023年11月22日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.14802/jmd.23213
- 共同研究・競争的資金等の研究課題
研究者
Hasegawa Masato
( )