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論文
- タイトル
- タイトル（英）
- Glia transmit negative valence information during aversive learning in Drosophila
- 参照URL
- https://researchmap.jp/minorusaitoe/published_papers/44317491
- 著者
- 著者（英）
- Tomoyuki Miyashita,Kanako Murakami,Emi Kikuchi,Kyouko Ofusa,Kyohei Mikami,Kentaro Endo,Takaaki Miyaji,Sawako Moriyama,Kotaro Konno,Hinako Muratani,Yoshinori Moriyama,Masahiko Watanabe,Junjiro Horiuchi,Minoru Saitoe
- 担当区分
- 概要
- 概要（英）
- During Drosophila aversive olfactory conditioning, aversive shock information needs to be transmitted to the mushroom bodies (MBs) to associate with odor information. We report that aversive information is transmitted by ensheathing glia (EG) that surround the MBs. Shock induces vesicular exocytosis of glutamate from EG. Blocking exocytosis impairs aversive learning, whereas activation of EG can replace aversive stimuli during conditioning. Glutamate released from EG binds to N -methyl- d -aspartate receptors in the MBs, but because of Mg 2+ block, Ca 2+ influx occurs only when flies are simultaneously exposed to an odor. Vesicular exocytosis from EG also induces shock-associated dopamine release, which plays a role in preventing formation of inappropriate associations. These results demonstrate that vesicular glutamate released from EG transmits negative valence information required for associative learning.
- 出版者・発行元
- 出版者・発行元（英）
- American Association for the Advancement of Science (AAAS)
- 誌名
- 誌名（英）
- Science
- 巻
- 382
- 号
- 6677
- 開始ページ
- 終了ページ
- 出版年月
- 2023年12月22日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 0036-8075
- DOI URL
- https://doi.org/10.1126/science.adf7429
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