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論文
- タイトル
- タイトル（英）
- Association of homocysteine with white matter dysconnectivity in schizophrenia.
- 参照URL
- https://researchmap.jp/masanariitokawa/published_papers/45876488
- 著者
- 著者（英）
- Koichi Tabata,Shuraku Son,Jun Miyata,Kazuya Toriumi,Mitsuhiro Miyashita,Kazuhiro Suzuki,Masanari Itokawa,Hidehiko Takahashi,Toshiya Murai,Makoto Arai
- 担当区分
- 概要
- 概要（英）
- Several studies have shown white matter (WM) dysconnectivity in people with schizophrenia (SZ). However, the underlying mechanism remains unclear. We investigated the relationship between plasma homocysteine (Hcy) levels and WM microstructure in people with SZ using diffusion tensor imaging (DTI). Fifty-three people with SZ and 83 healthy controls (HC) were included in this retrospective observational study. Tract-Based Spatial Statistics (TBSS) were used to evaluate group differences in WM microstructure. A significant negative correlation between plasma Hcy levels and WM microstructural disruption was noted in the SZ group (Spearman's ρ = -.330, P = 0.016) but not in the HC group (Spearman's ρ = .041, P = 0.712). These results suggest that increased Hcy may be associated with WM dysconnectivity in SZ, and the interaction between Hcy and WM dysconnectivity could be a potential mechanism of the pathophysiology of SZ. Further, longitudinal studies are required to investigate whether high Hcy levels subsequently cause WM microstructural disruption in people with SZ.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Schizophrenia (Heidelberg, Germany)
- 巻
- 10
- 号
- 1
- 開始ページ
- 39
- 終了ページ
- 39
- 出版年月
- 2024年3月20日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1038/s41537-024-00458-0
- 共同研究・競争的資金等の研究課題