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論文
- タイトル
- タイトル（英）
- Hyperglycaemia Aggravates Oxidised Low-Density Lipoprotein-Induced Schwann Cell Death via Hyperactivation of Toll-like Receptor 4.
- 参照URL
- https://researchmap.jp/351K/published_papers/46011508
- 著者
- 著者（英）
- Wataru Nihei,Ayako Kato,Tatsuhito Himeno,Masaki Kondo,Jiro Nakamura,Hideki Kamiya,Kazunori Sango,Koichi Kato
- 担当区分
- 概要
- 概要（英）
- Increased low-density lipoprotein levels are risk factors for diabetic neuropathy. Diabetes mellitus is associated with elevated metabolic stress, leading to oxidised low-density lipoprotein formation. Therefore, it is important to investigate the mechanisms underlying the pathogenesis of diabetic neuropathy in diabetes complicated by dyslipidaemia with increased levels of oxidised low-density lipoprotein. Here, we examined the effects of hyperglycaemia and oxidised low-density lipoprotein treatment on Schwann cell death and its underlying mechanisms. Immortalised mouse Schwann cells were treated with oxidised low-density lipoprotein under normo- or hyperglycaemic conditions. We observed that oxidised low-density lipoprotein-induced cell death increased under hyperglycaemic conditions compared with normoglycaemic conditions. Moreover, hyperglycaemia and oxidised low-density lipoprotein treatment synergistically upregulated the gene and protein expression of toll-like receptor 4. Pre-treatment with TAK-242, a selective toll-like receptor 4 signalling inhibitor, attenuated hyperglycaemia- and oxidised low-density lipoprotein-induced cell death and apoptotic caspase-3 pathway. Our findings suggest that the hyperactivation of toll-like receptor 4 signalling by hyperglycaemia and elevated oxidised low-density lipoprotein levels synergistically exacerbated diabetic neuropathy; thus, it can be a potential therapeutic target for diabetic neuropathy.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Neurology international
- 巻
- 16
- 号
- 2
- 開始ページ
- 370
- 終了ページ
- 379
- 出版年月
- 2024年3月19日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.3390/neurolint16020027
- 共同研究・競争的資金等の研究課題
研究者
三五 一憲
(サンゴ カズノリ)