TOPICS 2016
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Miharu Nakanishi（Mental Health Promotion Project）, received the recognition award 2016 from Mitsui Sumitomo Insurance Welfare Foundation.
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Calpain research for drug discovery: challenges and potential Nature Reviews Drug Discovery on-line, Yasuko Ono
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Caloric restriction promotes cell survival in a mouse model of normal tension glaucoma Scientific Reports, xiaoli guo
Scientific Reports 6, Article number: 33950 (2016)
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Mari Suzuki(Diabetic Neuropathy Project)won the Young Investigator Award of Japanese Society of Pathophysiology
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Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells Nature Communications, Hisao MasaiNature Communications 7, Article number: 12135 (2016)
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p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming Nature Communications, Keiji TanakaNature Communications 7, Article number: 12030 (2016)
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Thomson Reuters announces the research organization ranking by the number of the high cover quotation articles of Japan.
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As cases of dementia rise, Japan gropes for new ways to deal with them The Economist, Miharu NakanishiThe Economist Apr 9th 2016
HOME ＞ Topics2016 ＞ 11 November 2016
11 November 2016
Calpain research for drug discovery: challenges and potential Nature Reviews Drug Discovery on-line, Yasuko Ono (Calpain Project)
Calpain research for drug discovery:challenges and potential
Yasuko Ono1, Takaomi C. Saido2 and Hiroyuki Sorimachi1
1) Calpain Project, Department of Advanced Science for Biomolecules, Tokyo Metropolitan Institute of Medical Science （IGAKUKEN）,
2) Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute
Abstract
Calpains are a family of proteases that were scientifically recognized earlier than proteasomes and caspases, but remain enigmatic. However, they are known to participate in a multitude of physiological and pathological processes, performing ‘limited proteolysis’ whereby they do not destroy but rather modulate the functions of their substrates. Calpains are therefore referred to as ‘modulator proteases’. Multidisciplinary research on calpains has begun to elucidate their involvement in pathophysiological mechanisms. Therapeutic strategies targeting malfunctions of calpains have been developed, driven primarily by improvements in the specificity and bioavailability of calpain inhibitors. Here, we review the calpain superfamily and calpain-related disorders, and discuss emerging calpain-targeted therapeutic strategies.
Calpain Project ▶
