発表論文Publication

2023年

  • K. Miyashita*, T. Yagi*, N. Kagaya, A. Takechi, C. Nakata, R. Kanda, H. Nuriya, K. Tanegashima, S. Hoyano, F. Seki, C. Yoshida, Y. Hachiro, T. Higashi, N. Kitada, T. Toya, T. Kobayashi, Y. Najima, S. Goyama, S. A. Maki, T. Kitamura, N. Doki, K. Shin-ya, and T. Hara. Identification of compounds that preferentially suppress the growth of T cell acute lymphoblastic leukemia-derived cells. Cancer Sci., 114: 4032-4040, 2023. *First two authors equally contributed to the work.
  • T. Higashi, C. Yoshida, Y. Hachiro, C. Nakata, A. Takechi, T. Yagi, K. Miyashita, N. Kitada, R. Obata, T. Hirano, T. Hara, and S. A Maki. Synthesis and anti-tumor activities in human leukemia-derived cells of polyenylpyrroles with a methyl group at the conjugated polyene terminus. Bioorg. Med. Chem. Lett., 95: 129471, 2023.
  • 原 孝彦:マウス休眠期の皮膚で働く抗菌免疫システム. バイオサイエンスとインダストリー, 81: 28-29, 2023.

2022年

  • K. Kitajima*, M. Shingai, H. Ando, M. Hamasaki, and T. Hara*. An interferon-γ/FLT3 axis positively regulates hemopoietic progenitor cell expansion from human pluripotent stem cells. Stem Cells, 40: 906-918, 2022.
    *Co-corresponding authors.
  • K. Tsujihana*, K. Tanegashima*, Y. Santo, H. Yamada, S. Akazawa, R. Nakao, K. Tominaga, R. Saito, Y. Nishito, R. Hata, T. Nakamura, I. Murai, Y. Kono, M. Sugawa, M. Tanioka, G. Egawa, M. Doi, T. Isa, K. Kabashima, T. Hara**, and H. Okamura**. Circadian protection against bacterial skin infection by epidermal CXCL14-mediated innate immunity. Proc. Natl. Acad. Sci. U.S.A., 119: e2116027119, 2022. *Equally contributed authors, **Co-corresponding authors.
  • T. Suzuki, S. Takagi, and T. Hara. Multiple gene transfer and all-in-one conditional knockout systems in mouse embryonic stem cells for analysis of gene function. Front. Cell Dev. Biol., 10: 870629, 2022.

2021年

  • R. Iwase, N. Naruse, M. Nakagawa, R. Saito, A. Shigenaga, A. Otaka, T. Hara, and K. Tanegashima. Identification of functional domains of CXCL14 involved in high-affinity binding and intracellular transport of CpG DNA. J. Immunol., 207: 459-469, 2021.
  • T. Suzuki, E. Katada, Y. Mizuoka, S. Takagi, Y. Kazuki, M. Oshimura, M. Shindo, and T. Hara. A novel all-in-one conditional knockout system uncovered an essential role of DDX1 in ribosomal RNA processing. Nucl. Acid Res, 49: e40, 2021.
  • C. Yoshida, T. Higashi, Y. Hachiro, Y. Fujita, T. Yagi, A. Takechi, C. Nakata, K. Miyashita, N. Kitada, R. Saito, R. Obata, T. Hirano, T. Hara, and S. A. Maki. Synthesis of polyenylpyrrole derivatives with selective growth inhibitory activity against T-cell acute lymphoblastic leukemia cells. Bioorg. Med. Chem. Lett., 30: 127837, 2021.

2020年

  • K. Sato, M. Maeda, E. Kamata, S. Ishii, K. Yanagisawa, K. Kitajima, and T. Hara. Nitric oxide and a conditioned medium affect the hematopoietic development in a microfluidic mouse embryonic stem cell/OP9 co-cultivation system. Micromachines, 11: 305, 2020.
  • M. Paulis, L. Susani, A. Castelli, T. Suzuki, T. Hara, L. Straniero, S. Duga, D. Strina, S. Mantero, E. Caldana, L. S. Sergi, A. Villa, and P. Vezzoni. Chromosome transplantation: a possible approach to treat human X-linked disorders. Mol. Ther. Methods Clin. Dev., 17: 369-377, 2020.
  • T. Suzuki, Y. Kazuki, T. Hara, and M. Oshimura. Current advances in microcell-mediated chromosome transfer technology and its applications. Exp. Cell Res., 390: 111915, 2020.
  • 鈴木輝彦、原 孝彦:染色体導入法の原理と技術改良. 細胞, 52: 408-411, 2020.

2019年

  • M. Nakajima, T. Suzuki, T. Hara, and K. Kitajima. In vitro differentiation of mouse T cell-derived hybrid cells obtained through cell fusion with embryonic stem cells. Biochem. Biophys. Res. Commun., 513: 701-707, 2019.
  • H. Tabata, T. Hara, and K. Kitajima. Inhibitory action of an ERK1/2 inhibitor on primitive endoderm cell differentiation from mouse embryonic stem cells. Biochem. Biophys. Res. Commun., 512: 399-404, 2019.
  • N. Yokote, M. Y. Suzuki-Kosaka, T. Michiue, T. Hara, and K. Tanegashima. Latrophilin2 is involved in neural crest cell migration and placode patterning in Xenopus laevis. Int. J. Dev. Biol., 63: 29-35, 2019.

2018年

  • K. Kitajima, M. Kanokoda, M. Nakajima, and T. Hara. Domain-specific biological functions of the transcription factor Gata2 on hematopoietic differentiation of mouse embryonic stem cells. Genes Cells, 23: 753-766, 2018.
  • K. Tanaka, N. Ikeda, K. Miyashita, H. Nuriya, and T. Hara. DEAD box protein DDX1 promotes colorectal tumorigenesis through transcriptional activation of the LGR5 gene. Cancer Sci., 109: 2479-2489, 2018.
  • K. Miyashita, K. Kitajima, S. Goyama, T. Kitamura, and T. Hara. Overexpression of Lhx2 suppresses proliferation of human T cell acute lymphoblastic leukemia-derived cells, partly by reducing LMO2 protein levels. Biochem. Biophys. Res. Commun., 495: 2310-2316, 2018.

2017年

  • K. Tanegashima, R. Takahashi, H. Nuriya, R. Iwase, N. Naruse, K. Tsuji, A. Shigenaga, A. Otaka, and T. Hara. CXCL14 acts as a specific carrier of CpG DNA into dendritic cells and activates Toll-like receptor 9-mediated adaptive immunity. EBioMedicine, 24: 247-256, 2017.
  • T. Shinohara, K.Kazuki, N. Ogonuki, H. Morimoto, S. Matoba, K. Hiramatsu, K. Honma, T. Suzuki, T. Hara, A. Ogura, M. Oshimura, M. Kanatsu-Shinohara, and Y. Kazuki. Transfer of mouse artificial chromosome into spermatogonial stem cells generates transchromosomic mice. Stem Cell Rep., 9: 1180-1191, 2017.
  • K. Tanegashima, Y. Sato-Miyata, M. Funakoshi, Y. Nishito, T. Aigaki, and T. Hara. Epigenetic regulation of the glucose transporter gene Slc2a1 by β-hydroxybutyrate underlies preferential glucose supply to the brain of fasted mice. Genes to Cells, 22: 71-83, 2017.
  • H. Ohtsuka, T. Iguchi, M. Hayashi, M. Kaneda, K. Iida, M. Shimonaka, T. Hara, M. Arai, Y. Koike, N. Yamamoto, and K. Kasahara. SDF-1α/CXCR4 signaling in lipid rafts induces platelet aggregation via PI3 kinase-dependent Akt phosphorylation. PLoS ONE, 12: e0169609, 2017.

2016年

  • T. Suzuki, Y. Kazuki, M. Oshimura, and T. Hara. Highly efficient transfer of chromosomes to a broad range of target cells using Chinese hamster ovary cells expressing murine leukemia virus-derived envelope proteins. PLoS ONE, 11: e0157187, 2016.
  • K. Tamura, H. Naraba, T. Hara, K. Nakamura, M. Yoshie, H. Kogo, and E. Tachikawa. A positive feedback loop between progesterone and microsomal prostaglandin E synthase-1-mediated PGE2 promotes production of both in mouse granulosa cells. Prostaglandins Other Lipid Mediat., 123: 56-62, 2016.
  • M. Kawaguchi, K. Kitajima, M. Kanokoda, H. Suzuki, K. Miyashita, M. Nakajima, H. Nuriya, K. Kasahara, and T. Hara. Efficient production of platelets from mouse embryonic stem cells by enforced expression of Gata2 in late hemogenic endothelial cells. Biochem. Biophys. Res. Commun., 474: 462-468, 2016.
  • K. Kitajima, M. Nakajima, M. Kanokoda, M. Kyba, A. Dandapat, J. Tolar, M. K. Saito, M. Toyoda, A. Umezawa, and T. Hara. GSK3β inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells. Exp. Hematol., 44: 68-74, 2016.

2015年

  • K. Tsuji, K. Tanegashima, K. Sato, K. Sakamoto, A. Shigenaga, T. Inokuma, T. Hara*, and A. Otaka*. Efficient one-pot synthesis of CXCL14 and its derivative using an N-sulfanylethylanilide peptide as a peptide thioester equivalent and thier biological evaluation. Bioorg. Med. Chem., 23: 5909-5914, 2015. *Co-corresponding author.
  • K. Kitajima, M. Kawaguchi, K. Miyashita, M. Nakajima, M. Kanokoda, and T. Hara. Efficient production of T cells from mouse pluripotent stem cells by controlled expression of Lhx2. Genes to Cells, 20: 720-738, 2015.
  • Y. Kodaka, K. Tanaka, K. Kitajima, K. Tanegashima, R. Matsuda, and T Hara. LIM homeobox transcription factor Lhx2 inhibits skeletal muscle differentiation in part via transcriptional activation of Msx1 and Msx2. Exp. Cell Res., 331: 309-319, 2015.

2014年

  • T. Suzuki, Y. Kazuki, M. Oshimura, and T. Hara. A novel system for simultaneous or sequential integration of multiple gene-loading vectors into a defined site of a human artificial chromosome. PLoS ONE, 9: e110404, 2014.
  • T. Hara and K. Tanegashima. CXCL14 antagonizes the CXCL12-CXCR4 signaling axis. BioMol. Concepts 5: 167-173, 2014.
  • 原 孝彦、種子島幸祐:ケモカインと幹細胞:CXCL12-CXCR4軸を介した幹細胞誘引の調節因子。「日本薬理学雑誌Folia Pharmacologica Japonica」144, 4-7, 2014.

2013年

  • K. Kitajima, M. Kawaguch, M. Iacovino, M. Kyba, and T. Hara. Molecular functions of the LIM-homeobox transcription factor Lhx2 in hematopoietic progenitor cells derived from mouse embryonic stem cells. Stem Cells, 31: 2680-2689, 2013.
  • K. Tanegashima, K. Tsuji, K Suzuki, A. Shigenaga, A. Otaka, and T. Hara. Dimeric peptides of the C-terminal region of CXCL14 function as CXCL12 inhibitors. FEBS Letters, 587: 3770-3775, 2013.
  • K. Tanaka, K. Kondo, K. Kitajima, M. Muraoka, A. Nozawa, and T. Hara. Tumor-suppressive function of protein-tyrosine phosphatase non-receptor type 23 in testicular germ cell tumors is lost upon overexpression of miR142-3p microRNA. J. Biol. Chem., 288: 23990-23999, 2013.
  • K. Tanegashima, K Suzuki, Y. Nakayama, K. Tsuji, A. Shigenaga, A. Otaka, and T. Hara. CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis. FEBS Letters, 587: 1731-1735, 2013.

2012年

  • T. Hara and K. Tanegashima. Pleiotropic functions of the CXC-type chemokine CXCL14 in mammals. J. Biochem., 151: 469-476, 2012.
  • A. Ishimura, K. Minehata, M. Terashima, G. Kondoh, T. Hara, and T. Suzuki. Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression. Development, 139: 749-759, 2012.
  • Z. Zhao, L. Qin, B. Reid, J. Pu, T. Hara, and M. Zhao. Directing migration of endothelial progenitor cells with applied DC electric fields. Stem Cell Res., 8: 38-48, 2012.
  • 原 孝彦、北島健二:ES細胞・iPS細胞から機能的な血液細胞を作り出す方法。羊土社「実験医学」(増刊号) 30, 1671-1676, 2012.
  • 鈴木誠一、伊藤恵美子、長谷川世納、高橋勉、原 孝彦:流路形状による電界の絞り込みを用いたセルソータの特性改善。「電気学会論文誌C」132, 1595-1601, 2012.

2011年

  • K. Kitajima, K. Minehata, K. Sakimura, T. Nakano, and T. Hara. In vitro generation of HSC-like cells from murine ESCs/iPSCs by enforced expression of LIM-homeobox transcription factor Lhx2. Blood, 117: 3748-3758, 2011.
  • T. Hara. Thymosins and muscle regeneration. Vitamins and Hormones, 87: 277-290, 2011.
  • K. Tsuji, A. Shigenaga, Y. Sumikawa, K. Tanegashima, K. Sato, K. Aihara, T. Hara, and A. Otaka. Application of N to C- or C to N-directed sequential native chemical ligation to the preparation of CXCL14 analogs and their biological evaluation. Bioorg. Med. Chem., 19: 4014-4020, 2011.
  • K. Tatsumi, H. Yamamoto-Mukai, R. Shimizu, S. Waguri, Y.-S. Sou, A. Sakamoto, C. Taya, H. Shitara, T. Hara, C. H. Chung, K. Tanaka, M. Yamamoto, and M. Komatsu. The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice. Nat. Commun., 2: 181, 2011. (doi:10.1038/ncomms1182)
  • Y. Tokura, Y. Nakayama, S. Fukada, N. Nara, H. Yamamoto, R. Matsuda, and T. Hara. Muscle injury-induced thymosin beta4 acts as a chemoattractant for myoblasts. J. Biochem., 149: 43-48, 2011.
  • 北島健二、原 孝彦:iPS細胞から造血幹細胞への分化誘導。特集・次世代iPS医療。医歯薬出版株式会社「医学のあゆみ」239, 1397-1401, 2011.

2010年

  • T. Hara and K. Tanaka. DDX1 [DEAD (Asp-Glu-Ala-Asp) box polypeptide 1]. Atlas Genet. Cytogenet. Oncol. Haematol., URL: http://AtlasGeneticsOncology.org/Genes/DDX1ID40283ch2p24.html, June 2010.
  • K. Ohbayashi, K. Tanaka, K. Kitajima, K. Tamura, and T. Hara. Novel role for the intraflagellar transport protein CMG-1 in regulating the transcription of cyclin-D2, E-cadherin, and integrin-alpha family genes in mouse spermatocyte-derived cells. Genes to Cells.,15: 699-710, 2010.
  • K. Tanegashima, S. Okamoto, Y. Nakayama, C. Taya, H. Shitara, R. Ishii, H. Yonekawa, Y. Minokoshi, and T. Hara. CXCL14 deficiency in mice attenuates obesity and inhibits feeding behavior in a novel environment. PLoS ONE, 5: e10321, 2010.
  • K. Tanegashima, K. Suzuki, Y. Nakayama, and T. Hara. Antibody-assisted enhancement of biological activities of CXCL14 in human monocytic leukemia-derived THP-1 cells and high fat diet-induced obese mice. Exp. Cell Res., 316: 1263-1270, 2010.
  • 原 孝彦、種子島幸祐、岡本士毅、中山由紀、箕越靖彦:ケモカインCXCL14を介した摂食と糖代謝の調節。「自律神経」47, 248-251, 2010.

2009年

  • K. Tanaka, S. Okamoto, Y. Ishikawa, H. Tamura, and T. Hara. DDX1 is required for testicular tumorigenesis, partially through the transcriptional activation of 12p stem cell genes. Oncogene, 28: 2142-2151, 2009.
  • T. Hara and Y. Nakayama. CXCL14 and insulin action. Vitamins and Hormones 80: 107-123, 2009.
  • S. Ohata, M. Nawa, T. Kasama, T. Yamasaki, K. Sawanoboria, S. Hata, T. Nakamura, Y. Asaoka, T. Watanabe, H. Okamoto, T. Hara, S. Terai, I. Sakaida, T. Katada, and H. Nishina. Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells. Biochem. Biophys. Res. Commun., 379: 817-823, 2009.

2008年

  • M. Kutsukake, R. Ishihara, K. Momose, K. Isaka, O. Itokazu, C. Higuma, T. Matsutani, A. Matsuda , A. Sasajima, T. Hara, and K. Tamura. Circulating IGF-binding protein 7 (IGFBP7) levels are elevated in patients with endometriosis or undergoing diabetic hemodialysis. Reprod. Biol. Endocrinol., 6: 54, 2008.
  • T. Hara*, M. Schwieger, R. Kazama, S. Okamoto, K. Minehata, M. Ziegler, J. Lohler, and C. Stocking. Acceleration of chronic myeloproliferation by enforced expression of Meis1 or Meis3 in Icsbp-deficient bone marrow cells. Oncogene, 27: 3865-3869, 2008. *Corresponding author.
  • 原 孝彦:肥満と糖代謝におけるケモカインCXCL14の新たな役割。日本生化学会「生化学」80, 1133-1136, 2008.

2007年

  • N. Nara, Y. Nakayama, S. Okamoto, H. Tamura, M. Kiyono, M. Muraoka, K. Tanaka, C. Taya, H. Shitara, R. Ishii, H. Yonekawa, Y. Minokoshi, and T. Hara. Disruption of CXC motif chemokine ligand-14 in mice ameliorates obesity-induced insulin resistance. J. Biol. Chem., 282: 30794-30803, 2007.
  • M. Muraoka*, T. Miki, N. Ishida, T. Hara, and M. Kawakita. Variety of nucleotide sugar transporters with respect to the interaction wtih nucleoside mono- and diphosphates. J. Biol. Chem., 282: 24615-24622, 2007. *Corresponding author.
  • K. Tamura, M. Yoshie, T. Hara, K. Isaka, and H. Kogo. Involvement of stathmin in the proliferation and differentiation of immortalized human endometrial stromal cells. J. Reprod. Dev. , 53: 525-533, 2007.
  • E. Itakura, K. Odaira, K. Yokoyama, M. Osuna, T. Hara, and K. Inoue. Generation of transgenic rats expressing green fluorescent protein in S-100b-producing pituitary folliculo-stellate cells and brain astrocytes. Endocrinol., 148: 1518-1523, 2007.
  • L. Cao, H. Shitara, T. Horii, Y. Nagao, H. Imai, K. Abe, T. Hara, J. Hayashi, and H. Yonekawa. Mitochondrial bottleneck occurs without reduction of mtDNA content in mouse female germ cells. Nat. Genet., 39: 386-390, 2007.

2006年

  • K. Tamura, M. Yoshie, H. Nishi, Y. Osakabe, K. Isaka, T. Hara, and H. Kogo. Expression of stathmin in human uterus and decidualizing endometrial stromal cells. Reproduction, 132: 625-635, 2006.
  • T. Suzuki, Y. Kanai, T. Hara, J. Sasaki, T. Sasaki, M. Kohara, T. Maehama, C. Taya, H. Shitara, H. Yonekawa, M. A. Frohman, T. Yokozeki, and Y. Kanaho. Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol. Cell Biol., 26: 6149-6156, 2006.
  • R. Fujino, Y. Ishikawa, K. Tanaka, M. Kanatsu-Shinohara, K. Tamura, H. Kogo, T. Shinohara and T. Hara. Capillary morphogenesis gene (CMG)-1 is among the genes differentially expressed in mouse male germ line stem cells and embryonic stem cells. Mol. Reprod. Dev., 73: 955-966, 2006.
  • R. Fujino, K. Tanaka, M. Morimatsu, K. Tamura, H. Kogo, and T. Hara. Spermatogonial cell-mediated activation of an IkappaBzeta-independent NF-kappaB pathway in Sertoli cells induces transcription of the lipocalin-2 gene. Mol. Endocrinol., 20: 904-915, 2006.
  • M. Yoshie, K. Tamura, T. Hara, and H. Kogo. Expression of stathmin family genes in the murine uterus during early pregnancy. Mol. Reprod. Dev.,73: 164-172, 2006.

2005年

  • R. Doyonnas, J. S. Nielsen, S. Chelliah, E. Drew, T. Hara, A. Miyajima, and K. M. McNagny. Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells. Blood, 105: 4170-4178, 2005.
  • H. Eda, Y. Ishii, M. Obayashi, S. Harada, S. Ito, T. Fujita, M. Ikeda, S. Kusano, R. Kitamura, C. Suzuki, T. Hara, M. Watanabe, H. Satoh, K. Sugihara, and K. Yanagi. Monoclonal antibodies against regions topologically surrounding the homodimeric beta-barrel interface of Epstein-Bar virus nuclear antigen-1. Virus Research, 109: 87-94, 2005.
  • K. Iwatsuki, K. Tanaka, T. Kaneko, R. Kazama, S. Okamoto, Y. Nakayama, Y. Ito, M. Satake, S. Takahashi, A. Miyajima, T. Watanabe, and T. Hara. Runx1 promotes angiogenesis by downregulation of insulin-like growth factor binding protein-3. Oncogene, 24: 1129-1137, 2005.
  • 原 孝彦、中山由紀、奈良典子:骨格筋の再生医学。「臨床神経学」45, 880-882, 2005.

2004年以前の業績はこちら


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