No. | Field | Title | Description | Keywords, Other |
---|---|---|---|---|
1 | Nerve (nerve center) |
Cellular and animal models in neurodegenerative diseases | Cellular and animal models in the neurodegenrative diseases show the accumulation of abnormal protein of Tau, α-synuclein, or TDP-43. These disease models are useful for the screening of medicines in neurodegenerative disease such as AD, DLB, PD, and ALS. | AD, DLB, PD, ALS, Tau, α-synuclein, TDP-43, |
2 | Nerve (nerve center) |
A drug candidate compound for autism and intellectual disorder. | We found a protein regulating dendritic spine formation in hippocampal neurons. Administration of Compound X to model animals restored spine abnormalities, intellectual disorders and behavior deficits. | Spine formation, Drug repositioning Tuberous sclerosis complex, Autism, Intellectual disorder, |
3 | Nerve (nerve center) |
Neuropathology Database and web contents for collaborative research, E-learning, and development of automated diagnosis | We have more than 5,000 human brain specimens of neurological diseases, as well as high resolution WSI (whole slide images) organized into a library of neuropathological disorders. Our Neuropathology Database and web contents can be utilized for various collaborative research and education / training activities. In particular, we seek collaborations to develop automated systems to characterize and diagnose neurologic disease pathologies. | Digital Neuropathology, WSI (whole slide images) , Automated diagnosis, Neuropathological specimens |
4 | Dermatology | A novel topical treatment that is specific to Epidermal Hyperplasia Symptom | Lysoplasmalogen-specific Phospholipase D (LyPls-PLD) suppresses / improves the thickened epidermis in rodent models of both psoriasis and atopic dermatitis by hydorolyzing Lysoplasmalogen molecule P-LPE. The LyPls-PLD can be a novel topical treatment that improves specifically epidermal hyperplasia. |
Epidermal hyperplasia, Skin barrier, Phospholipase, Lysoplasmalogen |
5 | Protein Degradation |
"TR-TUBE Method" for detection of E3-specific ubiquitin substrates | An useful method for detection of ubiquitinated substrates efficiently and stably from cultured cells overexpressing a specific ubiquitin ligase E3. | Ubiquitination, Ubiquitin ligase E3, Ubiqutinated substrate |
6 | Autophagy | Atg7 cKO mouse | A conditional knockout mouse in which the function of a gene causative of autophagy (Atg7) is entirely or partly impaired depending on Cre recombinase. This mouse proves useful in analyzing disorders in which autophagy is involved. | Autophagy, Ubiquitin, Atg7 |
7 | Rare Diseases | “Modified NAGA (Mod. NAGA)” ~A Novel Enzyme for Fabry Disease~ |
Mod. NAGA, which shows GLA activity, was developped by modifying two amino acids of NAGA. Mod. NAGA does not react to serum from Fabry patients treated with a recombinant GLA. Mod. NAGA is a highly promising novel enzyme for ERT and Cell Therapy for Fabry disease. | Fabry disease, Modified enzyme, Avoidance of immunoreactions, Enzyme replacement therapy (ERT), Cell therapy |
8 | Medical Equipment | A novel quantitative / functional evaluation system for movement disorders | The classical neurological examination is not suitable to develop a new treatment because it is poorly quantitative and recordable. We proposed a functional evaluation system for movement disorders. Our system could provide an optimal treatment program for each patients with neurological movement disorders. |
PD, Stroke, SCD(Spinocerebellar degeneration), Patient's, condition evaluation, |