TOPICS 2017
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Naoko Niimi published a paper on “A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism” in Journal of Neurochemistry.
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Dr. Mari Suzuki of Diabetic Neuropathy Project had won the Young Investigator Award (basic research section) of the 36th Annual Meeting of Japan Society for Dementia Research.
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Dr. Syudo Yamasaki (Mental Health Promotion Project), received the Best Poster Award from 20th International Congress of International Society for Psychological and Social approaches to psychosis.
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Article publication on the effectiveness of psychosocial intervention programme for challenging behaviour of people with dementia. Miharu Nakanishi (Mental Health and Nursing Research Team)
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Yukiko Yoshida (Ubiquitin Project) published a paper on “Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy” in PNAS.
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Masato Hosokawa published a paper on “Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation” in Scientific Reports.
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Hikaru Tsuchiya (Laboratory of Protein Metabolism) published a paper on "Elucidation of the major pathway for proteasomal degradation" in Molecular Cell.
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Kaori Endo (Mental Health Promotion) published a paper on "preference
for solitude, social isolation, and suicidal problems in adolescence" in Journal of Adolescent Health.
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Phosphatidylethanolamine dynamics are required for osteoclast fusion Scientific Reports, Atsushi Irie.
Scientific Reports 7, Article number: 46715 (2017)
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Hisao Masai (Vice Director-general) received the 2017 Prize for MEXT Science and Technology (Research Category).
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Minoru Saitoe (Learning and Memory Project), is selected for winner of 19th Tokizane Prize.
HOME ＞ Topics2017 ＞ 19 May 2017
19 May 2017
Hikaru Tsuchiya (Laboratory of Protein Metabolism) published a paper on ”Elucidation of the major pathway for proteasomal degradation” in Molecular Cell.
Elucidation of the major pathway for proteasomal degradation
Tsuchiya et al. perform a quantitative MS analysis of ubiquitin linkage-type selectivity on 14 ubiquitin-binding effector proteins and the proteasome. The comprehensive analysis provides an overall picture of the Ub network via UBD proteins. Their work also reveals that proteasomal degradation is predominantly regulated by the Cdc48-Rad23/Dsk2 axis and that the Cdc48 cofactor Npl4 specifies the K48-linkage selectivity.
Tsuchiya, H., Ohtake, F., Arai, N., Kaiho, A., Yasuda, S., Tanaka, K., and Saeki, Y.
In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis
Contributes to K48-linked Chain Specificity of the Proteasome.
Mol Cell 66, 488-502 (2017)
Laboratory of Protein Metabolism ▶
