研究業績 ACHIEVEMENT

原著論文

令和6年度

  1. Sakuma H*, Thomas T, Takanashi JI, Mizuguchi M, Lim M, Dale RC, et al. International consensus definitions for infection-triggered encephalopathy syndromes. Dev Med Child Neurol. 2024 Aug 14. doi: 10.1111/dmcn.16067.
  2. Yamada N, Inoue T*, Kuki I, Yamamoto N, Sakuma H, Okazaki S, et al. Higher incidence of acute symptomatic seizures in probable antibody-negative pediatric autoimmune encephalitis than in major antibody-positive autoimmune encephalitis. Front Neurol 2024:15;1418083.
  3. Mori T, Matsuda S, Nishida H, Kohyama K, Fukuda M, Sakuma H*. Paediatric antibody prevalence in seizure score to predict autoimmune aetiology in seizure disorders. Dev Med Child Neurol. 2024 Apr 19. doi: 10.1111/dmcn.15927.
  4. Kasai M, Sakuma H*, Abe Y, Kuki I, Mizuguchi M, Takanashi JI; Japanese Pediatric Neuro-COVID-19 Study Group. Clinical characteristics of SARS-CoV-2-associated encephalopathy in children: Nationwide epidemiological study. J Neurol Sci. 2024:457:122867.
  5. Moriyama K, Horino A, Kohyama K, Nishito Y, Morio T, Sakuma H*. Oxygen-Glucose Deprivation Increases NR4A1 Expression and Promotes Its Extranuclear Translocation in Mouse Astrocytes. Brain Sci. 2024;14(3):244.
  6. Tadayuki Shimada*, Kuniko Kohyama, Tomoyuki Yoshida and Kanato Yamagata. (2024) Neuritin Controls Axonal Branching in Serotonin Neurons: A Possible Mediator Involved in the Regulation of Depressive and Anxiety Behaviors via FGF Signaling. J Neurosci. 2024; 44 (41): 1-17.

    7. 令和5年度

  7. Horino-Shimizu A, Moriyama K, Mori T, Kohyama K, Nishito Y, Sakuma H*. Lipocalin-2 production by astrocytes in response to high concentrations of glutamate. Brain Res. 2023 Jun 14;1815:148463.
  8. Tsuboi M, Nakamura Y, Sakuma H. Direct effect of 2-palmitoyl glycerol on promotion of gamma aminobutyric acid synthesis in normal human fetal-derived astrocytes. FEBS Open Bio. 2023:13:1320-1332.
  9. Sakuma H* & Takanashi JI, Muramatsu K, Kasai M, Tada H, Mizuguchi M, et al. Severe pediatric acute encephalopathy syndromes related to SARS-CoV-2. Front Neurosci. 2023 :17:1085082.
  10. Kohyama K, Nishida H, Kaneko K, Misu T, Nakashima I, Sakuma H*. Complement-dependent cytotoxicity of human autoantibodies against myelin oligodendrocyte glycoprotein. Front Neurosci. 2023: 17; 1014071.
  11. Hatano K, Fujimoto A*, Sato K, Yamamoto T, Sakuma H, Enoki H. Unexplained Progressive Neurological Deficits after Corpus Callosotomy May Be Caused by Autoimmune Encephalitis: A Case of Suspected Postoperative Anti-NMDAR Encephalitis. Brain Sci. 2023;13:135.
  12. Tomioka K, Nishiyama M, Tokumoto S, Yamaguchi H, Sakuma H, Nagase H*, et al. Time course of serum cytokine level changes within 72 h after onset in children with acute encephalopathy and febrile seizures. BMC Neurol. 2023;23:7.
  13. Murofushi Y, Sakuma H, Tada H, Mizuguchi M, Takanashi JI*. Changes in the treatment of pediatric acute encephalopathy in Japan between 2015 and 2021: A national questionnaire-based survey. Brain Dev. 2023;45:153-160.

    14. 令和4年度

  14. Katoh Y, Iriyama T, Kotajima-Murakami H, Sakuma H, Ikeda K, Osuga Y, et al. Increased production of inflammatory cytokines and activation of microglia in the fetal brain of preeclamptic mice induced by angiotensin II. J Reprod Immunol. 2022;154:103752.
  15. Yamamoto N, Inoue T, Kuki I, Okazaki S, Sakuma H, Kawawaki H, et al. A pediatric case of autoimmune glial fibrillary acidic protein astrocytopathy with unique brain imaging patterns and increased cytokines/chemokines. Brain Dev. 2022;44:753-758.
  16. Fujita Y, Imataka G, Sakuma H, Takanashi JI, Yoshihara S. Multiple encephalopathy syndrome: a case of a novel radiological subtype of acute encephalopathy in childhood. Eur Rev Med Pharmacol Sci. 2022;26:5729-5735.
  17. Ochiai S, Hayakawa I, Ohashi E, Miyata Y, Sakuma H, Abe Y, et al. Fatal X-linked lymphoproliferative disease type 1-associated limbic encephalitis with positive anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antibody. Brain Dev. 2022 ;44:630-634.
  18. Yamada N, Kuki I, Okazaki S, Kawawaki H, Horino A, Sakuma H, et al. Late relapse of anti-N-methyl-d-aspartate receptor encephalitis with amusia and transiently reduced uptake in 123I-iomazenil single-photon emission computed tomography. Brain Dev. 2022 ;44:558-561.
  19. Inoue Y, Hamano SI, Hayashi M, Sakuma H, Hirose S, Ishii A, et al. Burden of seizures and comorbidities in patients with epilepsy: a survey based on the tertiary hospital-based Epilepsy Syndrome Registry in Japan. Epileptic Disord. 2022;24:82-94.
  20. Horita T, Inoue T, Kuki I, Kawawaki H, Sakuma H, Togawa M, et al. A case of bilateral limbic and recurrent unilateral cortical encephalitis with anti-myelin oligodendrocyte glycoprotein antibody positivity. Brain Dev. 2022;44:254-258.
  21. Yamamoto N, Inoue T, Kuki I, Okazaki S, Sakuma H, Kawawaki H, et al. A pediatric case of autoimmune glial fibrillary acidic protein astrocytopathy with unique brain imaging patterns and increased cytokines/chemokines. Brain Dev. 2022;44:753-758.
  22. Okada T, Fujita Y, Imataka J, Tada H, Sakuma H, *Takanashi JI, et al. Increased cytokines/chemokines and hyponatremia as a possible cause of clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with acute focal bacterial nephritis. Brain Dev. 2022;44:30-35.

    23. 令和3年度

  23. Yamamoto N, Kuki I, Inoue T, S Okazaki, Sakuma H, Kawawaki H, et al. Subtotal hemispherotomy for late-onset spasms after anti-myelin oligodendrocyte glycoprotein antibody-positive acute haemorrhagic leukoencephalitis. Epileptic Disord. 2021 ;23:957-960.
  24. Nosadini M, Eyre M, Sakuma H, Dalmau J, Dale RC, *Lim M, et al. Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephalitis: A Meta-analysis. JAMA Neurol. 2021;78:1333-1344.
  25. Nosadini M, Thomas T, Sakuma H, Dalmau J, Lim M, *Dale RC, et al. International Consensus Recommendations for the Treatment of Pediatric NMDAR Antibody Encephalitis. Neurol Neuroimmunol Neuroinflam. 2021;8:e1052.
  26. Yoshitomi S, Hamano SI, Hayashi M, Sakuma H, Hirose S, *Inoue Y, et al. Current medico-psycho-social conditions of patients with West syndrome in Japan. Epileptic Disord. 2021 ;23:579-589.
  27. *Yamada N, Yamasaki K, Yamamoto N, Kuki I, Sakuma H, Hara J, et al. Chemotherapy-induced autoimmune-mediated encephalitis during germinoma treatment. Brain Dev. 2021;43:967-971.
  28. *Nishida H, Kohyama K, Kumada S, Takanashi JI, Okumura A, Horino A, Moriyama K, Sakuma H. Evaluation of the Diagnostic Criteria for Anti-NMDA Receptor Encephalitis in Japanese Children. Neurology. 2021;96:e2070-e2077.
  29. *Azumagawa K, Nakashima I, Kaneko K, Kira R, Sakuma H, Tamai H, et al. A nation-wide survey of Japanese pediatric MOG antibody-associated diseases. Brain Dev. 2021;43:705-713.
  30. Horino A, *Kuki I, Inoue T, Kawawaki H, Shiomi M, *Sakuma H, et al. Intrathecal dexamethasone therapy for febrile infection-related epilepsy syndrome. Ann Clin Transl Neurol. 2021;8:645-655.
  31. *Yamanaka G, Takamatsu T, Sakuma H, Yoshimoto T, Kato M, Kawashima H, et al. Interleukin-1β in peripheral monocytes is associated with seizure frequency in pediatric drug-resistant epilepsy. J Neuroimmunol. 2021;352:577475.
  32. Kanai S, Okanishi T, Kawai M, Sakuma H, Kurahashi H, *Maegaki Y, et al. Late-onset cerebral arteriopathy in a patient with incontinentia pigmenti. Brain Dev. 2021;43:580-584.
  33. Yamaguchi H, Nishiyama M, Sakuma H, Tada H, Maruyama A, *Nagase H, et al. Elevated cytokine, chemokine, and growth and differentiation factor-15 levels in hemorrhagic shock and encephalopathy syndrome: A retrospective observational study. Cytokine. 2021;137:155324.
  34. Mizuguchi M, Ichiyama T, Imataka G, Okumura A, Goto T, Sakuma H, et al. Guidelines for the diagnosis and treatment of acute encephalopathy in childhood. Brain Dev. 2021;43:2-31.

    35. 令和2年度

  35. Takamatsu T, Yamanaka G, Uryu H, Shichino H, Sakuma H, Kawashima H, et al. Improvement in recurrent anti-myelin oligodendrocyte glycoprotein antibody - positive cerebral cortical encephalitis not requiring anti - inflammatory therapy following the decrease in cytokine/chemokine levels. Mult Scler Relat Disord. 2020;43:102168.
  36. Kasai M, Shibata A, Hoshino A, Sakuma H, Oka A, *Mizuguchi M, et al. Epidemiological changes of acute encephalopathy in Japan based on national surveillance for 2014-2017. Brain Dev. 2020;42:508-514.
  37. Suzuki T, Kohyama K, Moriyama K, Ozaki M, Hasegawa S, Ueno T, Saitoe M, Morio T, Hayashi M, *Sakuma H. Extracellular ADP augments microglial inflammasome and NF-κB activation via the P2Y12 receptor. Eur J Immunol. 2020;50:205-219.
  38. *Matsuura R, hamano S, Daida A, Nonoyama H, Kubota J, Ikemoto S, Hirata Y, Koichihara R, Kikuchi K, Yamaguchi A, Sakuma H, Takahashi Y. Serum matrix metallopeptidase-9 and tissue inhibitor of metalloproteinase-1 levels in autoimmune encephalitis. Brain Dev 2020;42:264-269.

    39. 令和元年度

  39. Suzuki T, Kohyama K, Moriyama K, Ozaki M, Hasegawa S, Ueno T, Saitoe M, Morio T, Hayashi M, *Sakuma H. Extracellular ADP augments microglial inflammasome and NF-κB activation via the P2Y12 receptor. Eur J Immunol. 2019 Sep 24. doi: 10.1002/eji.201848013.
  40. Hasegawa S, Sakuma H, Kashimada K, Imai K, Morio T, Hayashi M, Mizutani S, *Takagi M, et al. Long-Term Evaluation of Low-Dose Betamethasone for Ataxia Telangiectasia. Pediatr Neurol. 2019;100:60-66.3.

    41. 平成30年度

  41. Igarashi A, *Sakuma H, Hayashi M, Noto D, Miyake S, Okumura A, Shimizu T. Cytokine-induced differentiation of hematopoietic cells into microglia-like cells in vitro. Clin Exp Neuroimmunol 2018 9:139-149. doi: 10.1111/cen3.12429（査読あり）
  42. Shima T, *Sakuma H, Suzuki T, Kohyama K, Matsuoka T, Hayashi M, Okumura A, Shimizu T. Effects of antiepileptic drugs on microglial properties. Epilepsy Seizure 2018 10: 22-32.（査読あり）
  43. Okumura R, Yamazaki S, Ohashi T, Magara S, Tohyama J, Sakuma H, Hayashi M, Saitoh A. Neuropsychiatric Disorder Associated with Group G Streptococcus Infection. Case Rep Pediatr. 2018:6047318.（査読あり）
  44. Takanashi JI, Yasukawa K, Murofushi Y, Masunaga A, Sakuma H, Hayashi M. Loss of myelinated axons and astrocytosis in an autopsy case of acute encephalopathy with biphasic seizures and late reduced diffusion. Brain Dev. 2018;40:947-951.
  45. Omae T, Saito Y, Tsuchie H, Ohno K, Maegaki Y, Sakuma H. Cytokine/chemokine elevation during the transition phase from HSV encephalitis to autoimmune anti-NMDA receptor encephalitis. Brain Dev 2018 40:361-365.

    46. 平成29年度

  46. Ishida S, Yasukawa K, Koizumi M, Abe K, Hirai N, Honda T, Sakuma H, Tada H, Takanashi JI. Excitotoxicity in encephalopathy associated with STEC O-157 infection. Brain Dev. 2018 40:357-360. （査読あり）
  47. Omata T, Kodama K, Watanabe Y, Iida Y, Furusawa Y, Takashima A, Takahashi Y, Sakuma H, Tanaka K, Fujii K, Shimojo N. Ovarian teratoma development after anti-NMDA receptor encephalitis treatment. Brain Dev. 2017;39:448-451.
  48. Saika R, *Sakuma H, Noto D, Yamaguchi S, Yamamura T, Miyake S. MicroRNA-101a regulates microglial morphology and inflammation. J Neuroinflammation. 2017 14:109.

    49. 平成28年度

  49. Hayashi M, Sakuma H. Immunohistochemical Analysis of Brainstem Lesions in the Autopsy Cases with Severe Motor and Intellectual Disabilities Showing Sudden Unexplained Death. Front Neurol. 2016 7:93.
  50. Miyata R, Tanuma N, Sakuma H, Hayashi M. Circadian Rhythms of Oxidative Stress Markers and Melatonin Metabolite in Patients with Xeroderma Pigmentosum Group A. Oxid Med Cell Longev. 2016; 5741517.
  51. Omata T, Takahashi Y, Sakuma H, Tanaka K, Fujii K, Shimojo N, et al. Ovarian teratoma development after anti-NMDA receptor encephalitis treatment. Brain Dev. 2016 39:448-451.
  52. Fujita Y, Takanashi J, Takei H, Ota S, Fujii K, Sakuma H, Hayashi M. Activated microglia in acute encephalopathy with biphasic seizures and late reduced diffusion. J Neurol Sci. 2016;366:91-3.
  53. Takasawa K, Takeda S, Nishioka M, Sakuma H, Morio T, Shimohira M. Steroid-responsive status epilepticus caused by human parvovirus B19 encephalitis. Pediatr Infect Dis J. 2016;35:227-8.
  54. Tamasaki A*, Saito Y, Ueda R, Ohno K, Yokoyama K, Satake T, Sakuma H, Takahashi Y, Kondoh T, Maegaki Y. Effects of donepezil and serotonin reuptake inhibitor on acute regression during adolescence in Down syndrome. Brain Dev. 2016 38:113-7.

    55. 平成27年度

  55. Sakuma H, Tanuma N, Kuki I, Takahashi Y, Shiomi M, Hayashi M. Intrathecal overproduction of proinflammatory cytokines and chemokines in febrile infection-related refractory status epilepticus. J Neurol Neurosurg Psychiatr. 2015;86:820-2.
  56. Nakahara E, Sakuma H, Kimura-Kuroda J, Shimizu T, Okumura A, Hayashi M. A diagnostic approach for identifying anti-neuronal antibodies in children with suspected autoimmune encephalitis. J Neuroimmunol 2015:285:150-5.
  57. Higurashi N, Takahashi Y, Kashimada A, Sugawara Y, Sakuma H, at al. Immediate suppression of seizure clusters by corticosteroids in PCDH19 female epilepsy. Seizure 2015 27:1-5.
  58. Kimura K, Nagao Y, Hachimori K, Hayashi M, Nomura Y, Segawa M. Pre-movement gating of somatosensory evoked potentials in Segawa disease. Brain Dev (in press)　2015 Jun 11. doi: 10.1016/j.braindev.2015.05.007.
  59. Shimojima K, Okumura A, Hayashi M, Kondo T, Inoue H, Yamamoto T. CHCHD2 is down-regulated in neuronal cells differentiated from iPS cells derived from patients with lissencephaly Genomics 2015 Oct;106(4):196-203.
  60. Kubota M, Ohta S, Ando A, Koyama A, Terashima H, Kashii H, Hoshino H, Sugita K, Hayashi M. Nationwide survey of Cockayne syndrome in Japan: its incidence, clinical course and prognosis. Pediatr Int 2015 Jun;57(3):339-47.
  61. Ozaki K, Sanjo N, Ishikawa K, Higashi M, Hattori T, Tanuma N, Miyata R, Hayashi M, Yokota T, Okawa A, Mizusawa H. Elevation of 8-hydroxy-2′-deoxyguanosine in the cerebrospinal fluid of three patients with superficial siderosis. Neurol Clin Neurosci 2015 May:3(3):108-110
  62. Palmela P, Pereila P, Hayashi M, Brites D, Brito A. Histological findings in the kernicterus-associated vulnerable brain regions are linked to neurodegeneration, alterations in astrocyte and pericyte distribution, and vascular modifications. Int J Pathol Clin Res 1:003. 2015;1(1):11 pages, published in April 29, 2015.

    63. 平成26年度

  63. Tanuma N, Miyata R, Nakajima K, Okumura A, Kubota M, Hamano S, Hayashi M. Cerebrospinal fluid oxidative stress markers and tau protein in human herpesvirus-6 associated acute encephalopathy/febrile seizures. Mediators Inflamm 2014 (in press) doi: 10.1155/2014/564091.
  64. Miyata R, Hayashi M, Itoh E. Pathological changes in the cardiac muscles and the cerebellar cortex in Vici syndrome. Am J Med Genet A 2014 (in press) doi: 10.1002/ajmg.a.36753.
  65. Okoshi Y, Tanuma N, Miyata R, Hayashi M. Melatonin alterations and brain acetylcholine lesions in sleep disorders in Cockayne syndrome. Brain Dev 2014 (in press). doi: 10.1016/j.braindev.2014.01.004.
  66. Okoshi Y, Hayashi M, Kanda S, Yamamoto T. An autopsy case of microencephaly, bizarre putaminal lesion, and cerebellar atrophy with heart and liver diseases. Brain Dev 2014 (in press). doi: 10.1016/j.braindev.2013.11.010.
  67. Noto D and Sakuma H (double first authors), Takahashi K, Saika R, Saga R, Yamada M, Yamamura T, Miyake S. Development of a culture system to induce microglia-like cells from haematopoietic cells. Neuropathol Appl Neurobiol 2014; 40: 697-713.
  68. 1. Itoh M, Iwasaki Y, Ohno K, Inoue T, Hayashi M, Ito S, Matsuzaka T, Ide S, Arima M. Nationwide survey of Arima syndrome: Revised diagnostic criteria from epidemiological analysis. Brain Dev 2014; 36(5): 388-393
  69. 福水道郎、林雅晴、宮島祐、石崎朝世、田中肇、神山潤．メラトニン、ラメルテオン小児使用例に関する全国調査．脳と発達（in press）

    70. 平成25年度

  70. Hachiya Y, Uruha A, Kasai-Yoshida E, Shimoda K, Satoh-Shirai I, Kumada S, Kurihara E, Suzuki K, Ohba A, Hamano SI, Sakuma H. Rituximab ameliorates anti-N-methyl-d-aspartate receptor encephalitis by removal of short-lived plasmablasts. J Neuroimmunol 2013; 265(1-2): 128-130.
  71. Hachiya Y, Miyata R, Tanuma N, Hongo K, Tanaka K, Shimoda K, Kanda S, Hoshino A, Hanafusa Y, Kumada S, Kurihara E, Hayashi M. Autoimmune neurological disorders associated with group-A beta-hemolytic streptococcal infection. Brain Dev 2013; 35(7): 670-674.
  72. Saito T, Saito Y, Sugai K, Nakagawa E, Komaki H, Okazaki T, Ishido Y, Kaneko Y, Kaido T, Takahashi A, Ohtsuki T, Sakuma H, Sasaki M. Late-onset epilepsy in children with acute febrile encephalopathy with prolonged convulsions: A clinical and encephalographic study. Brain Dev 2013; 35(6): 531-539.
  73. Okumura A, Hayashi M, Shimojima K, Ikeno M, Uchida T, Takanashi JI, Okamoto N, Hisata K, Shoji H, Saito A, Furukawa T, Kishida T, Shimizu T, Yamamoto T. Whole-exome sequencing of a unique brain malformation with periventricular heterotopia, cingulate polymicrogyria and midbrain tectal hyperplasia. Neuropathology 2013; 33(5): 553-560.
  74. Shiohama T, Fujii K, Hayashi M, Hishiki T, Suyama M, Mizuochi H, Uchikawa H, Yoshida S, Yoshida H, Kohno Y. Phrenic nerve palsy associated with birth trauma – case reports and a literature review. Brain Dev 2013; 35(4): 361-366.
  75. Segawa M, Nomura Y, Hayashi M. Dopa-responsive dystonia is caused by particular impairment of nigrostriatal dopamine neurons different from those involved in Parkinson disease: evidence observed in studies on Segawa disease. Neuropediatrics 2013; 44(2): 61-66.
  76. Okumura A, Lee T, Ikeno M, Shimojima K, Kajino K, Inoue Y, Yoshikawa N, Suganuma H, Suzuki M, Hisata K, Shoji H, Takanashi J, Barkovich AJ, Shimizu T, Yamamoto T, Hayashi M. A severe form of epidermal nevus syndrome associated with brainstem and cerebellar malformations and neonatal medulloblastoma Brain Dev 2013; 35(3): 274-279.
  77. Igarashi A, Okumura A, Kitamura Y, Jinbo K, Akatsuka S, Tanuma N, Shimizu T, Hayashi M. Acute limbic encephalitis with focal hyperperfusion on single photon emission computed tomography. Brain Dev 2013; 35(2): 181-184.
  78. Cullup T, Kho AL, Dionisi-Vici C, Brandmeier B, Smith F, Urry Z, Simpson MA, Yau S, Bertini E, McClelland V, Al-Owain M, Koelker S, Koerner C, Hoffmann GF, Wijburg FA, Hoedt AE, Rogers RC, Manchester D, Miyata R, Hayashi M, Said E, Soler D, Kroisel PM, Windpassinger C, Filloux FM, Al-Kaabi S, Hertecant J, Del Campo M, Buk S, Bodi I, Goebel HH, Sewry CA, Abbs S, Mohammed S, Josifova D, Gautel M, Jungbluth H. Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy. Nat Genet 2013; 45(1): 83-87.
  79. 中島啓介、林雅晴．福山型先天性筋ジストロフィー剖検例での脳幹機能の検討．脳と発達 2013; 45(6): 436-439.

    80. 平成24年度

  80. Hachiya Y, Hayashi M, Negishi T, Atsumi S, Kubota M, Nishihara T. A case of osteogenesis imperfecta type II caused by a novel COL1A2 gene mutation: endoscopic third ventriculostomy to prevent hydrocephalus. Neuropediatrics 2012; 43(4): 225-228.
  81. Takanashi J, Hayashi M, Yuasa S, Satoh H, Terada H. Hypomyelination in I-cell disease; MRI, MR spectroscopy and neuropathological correlation. Brain Dev 2012;34(9):780-783.
  82. Kitamura Y, Okumura A, Hayashi M, Mori H, Takahashi S, Yanagihara K, Miyata R, Tanuma N, Mimaki T, Abe S, Shimizu T. Oxidative stress markers and phosphorus magnetic resonance spectroscopy in a patient with GLUT1 deficiency treated with modified Atkins diet. Brain Dev 2012;34(5):372-375.
  83. Miyata R, Tanuma N, Hayashi M, Takahashi Y. Focal encephalopathy having recurrent episodes of epileptic status and cluster mimicking hemiconvulsion-hemiplegia-epilepsy syndrome. Brain Dev 2012;34(5):360-363.
  84. 1. Hayashi M, Oto T, Shioda K, Fukatsu R. Lesions of cortical GABAergic interneurons and acetylcholine neurons in xeroderma pigmentosum group A. Brain Dev 2012; 34(4): 287-292.
  85. Hayashi M, Saito-Miwa N, Tanuma N, Kubota M. Brain vascular changes in Cockayne syndrome. Neuropathology 2012; 32(2): 113-117.
  86. Nakajima K, Hayashi M, Tanuma N, Morio T. An autopsy case of polymicrogyria and intracerebral calcification dying the intracerebral hemorrhage. Neuropathology 2012; 32(2): 107-110.
  87. Kuroda-Kimura J, Kuroda Y, Hayashi M, Kawano H. Nicotine-like effects of the neonicotinoid insecticides acetamiprid and imidacloprid on cerebellar neurons of neonatal rats. PLoS ONE 2012; 7(2): e32432.
  88. Tanaka R, Iwasaki N, Hayashi M, Nakayama J, Ohto T, Takahashi M, Numano T, Homma K, Hamano K, Sumazaki R. Abnormal brain MRI signal in 18q- syndrome not due to dysmyelination. Brain Dev 2012; 34(3): 234-237.
  89. Inui T, Saito Y, Sakuma H, Hatakeyama H, Goto YI, Arai H, Sasaki M. Profiles of blood biomarkers in alternating hemiplegia of childhood - Increased MMP-9 and decreased substance P indicates its pathophysiology. Brain Dev 2012; 34(3): 196-200.
  90. Miyata R, Hayashi M, Tanuma N, Imamura T, Takanashi J, Nagata R, Okumura A, Kashii H, Tomita S, Kumada S, Kubota M. Oxidative stress in mild encephalitis/encephalopathy with a reversible splenial lesion (MERS). Brain Dev 2012; 34(2): 124-127.

    91. 平成23年度

  91. Hayashi M, Miyata R, Tanuma N. Decrease in acetylcholinergic neurons in the pedunculopontine tegmental nucleus in a patient with Prader-Willi syndrome. Neuropathology 2011; 31(3):280-285.
  92. Sakuma H, Katayama A, Saito Y, Komaki H, Nakagawa E, Sugai K, Sasaki M. CD4+ CD25(high) regulatory T cell in childhood ocular myasthenia gravis. Brain Dev 2011; 33(5):442-444.
  93. Shioda M, Hayashi M, Takanashi J, Osawa M. Lesions in the central tegmental tract in autopsy cases of developmental brain disorders. Brain Dev 2011:33(7):541-547.
  94. Hanai S, Komaki H, Sakuma H, Nakagawa E, Sugai K, Sasaki M, Oya Y, Higurashi N, Hamano S. Acute autonomic sensory and motor neuropathy associated with parvovirus B19 infection. Brain Dev 2011; 33(2):161-165.
  95. 林雅晴. 運動障害・嚥下障害で発症し2年11カ月の経過で死亡した3歳女性. 脳と発達 2011; 43(2): 3-4.
  96. 安西有紀、林雅晴、松岡正樹、高橋宏行、宮田理英、田沼直之、大矢達男．パンデミック（H1N1）2009インフルエンザ感染により脳幹病変を呈した急性脳症の1例．脳と発達 2011; 43(1): 57-59.
  97. 林雅晴. 運動障害・嚥下障害で発症し2年11カ月の経過で死亡した3歳女性. 脳と発達 2011; 43(1): 85-86.

    98. 平成22年度

  98. Hayashi M, Hachiya Y, Arai N. An autopsy report of case showing repetitive hypoglycemia and unique cortical dysplasia. Brain Dev 2010; 32 (4): 289-292.
  99. Sakuma H, Sugai K, Sasaki M. Acute nonparaneoplastic limbic encephalitis in childhood: a case series in Japan. Pediatr Neurol 2010; 43(3): 167-172.
  100. Sakuma H, Awaya Y, Shiomi M, Yamanouchi H, Takahashi Y, Saito Y, Sugai K, Sasaki M. Acute encephalitis with refractory, repetitive partial seizures (AERRPS): a peculiar form of childhood encephalitis. Acta Neurol Scand 2010; 121(4):251-256.
  101. Sakuma H, Shimizu Y, Saito Y, Sugai K, Inagaki M, Kaga M, Sasaki M. Electrophysiological evidence of cerebral dysfunction in childhood opsoclonus-myoclonus syndrome. Mov Disord 2010; 25(7): 940-945.
  102. Itoh M, Takizawa Y, Hanai S, Okazaki S, Miyata R, Inoue T, Akashi T, Hayashi M, Goto YI. Partial loss of pancreas endocrine and exocrine cells of human ARX-null mutation: consideration of pancreas differentiation. Differentiation 2010; 80(2-3): 118-122.
  103. Suganuma H, Arai Y, Kitamura Y, Hayashi M, Okumura A, Shimizu T. Maternal docosahexaenoic acid-enriched diet prevents neonatal brain injury. Neuropathology 2010; 30(6): 597-605.
  104. Negi M, Kobayashi D, Kumagai J, Kuroiwa T, Shiraishi J, Takemura T, Irahara K, Hayashi M, Eishi Y. An autopsy case of congenital hydrocephalus and severe thinning of the cerebral cortex in a 4-year-old boy. Neuropathology 2010; 30(5): 559-563.
  105. Miyata R, Sasaki T, Hayashi M, Araki S, Shimohira M, Kohyama J. Low dose of levodopa is effective for laryngeal dystonia in xeroderma pigmentosum group A. Brain Dev 2010; 32(8): 685-687.
  106. Tanuma N, Miyata R, Kumada S, Kubota M, Takanashi J, Okumura A, Hamano S, Hayashi M. The axonal damage marker tau protein in the cerebrospinal fluid is increased in patients with acute encephalopathy with biphasic seizures and late reduced diffusion. Brain Dev 2010; 32(6): 435-439.
  107. Oba D, Hayashi M, Minamitani M, Hamano S, Uchisaka N, Kikuchi A, Kishimoto H, Takagi M, Morio T, Mizutani S. Autopsic study of cerebellar degeneration in siblings with ataxia-telangiectasia-like disorder (ATLD). Acta Neuropathol 2010; 119(4): 513-520.
  108. Kanda S, Saito M, Hayashi M, Atsumi S, Komine S, Tanuma N. Hypoglossal hypoplasia and hyperplasia of the area postrema following perinatal hypoxic brain damage. Brain Dev 2010; 32(4): 285-288.
  109. Sekigawa M, Okumura A, Niijima S, Hayashi M, Tanaka K, Shimizu T. Autoimmune focal encephalitis shows marked hypermetabolism on positron emission tomography. J Pediatrics 2010; 156(1): 158-160.
  110. Saito Y, Inui T, Sakakibara T, Sugai K, Sakuma H, Sasaki M. Evolution of hemiplegic attacks and epileptic seizures in alternating hemiplegia of childhood. Epilepsy Res 2010; 90: 248-258.
  111. 三輪菜穂、田沼直之、*林雅晴．著明な高IgE血症を呈した重症心身障害児の剖検例．脳と発達 2010; 42(5): 367-371.
  112. 1. 白井謙太郎、中島啓介、渡辺章充、川野豊、林雅晴. 運動中に発症した中脳周囲非動脈瘤性クモ膜下出血の6歳女児例. 脳と発達 2010; 42(1): 60-62.（

総説論文

令和6年度

  1. *佐久間啓. 脊髄性筋萎縮症スクリーニングの実際. 拡大新生児スクリーニング検査の成果と展望. 医学のあゆみ. 2024:290;25214-17.3

    2. 令和5年度

  2. Mizuguchi M, Shibata A, Kasai M, Hoshino A. Genetic and environmental risk factors of acute infection-triggered encephalopathy. Front Neurosci. 2023 Jan 24:17:1119708（査読あり）

    3. 令和4年度

  3. Shimada T, Yamagata K, Spine morphogenesis and synapse formation in tubular sclerosis complex models. Front Mol Neurosci. 2022. doi: 10.3389/fnmol.2022.1019343. （査読あり）
  4. *佐久間啓. 自己免疫性脳炎と感染症 小児の抗NMDA受容体脳炎と感染症との関連. NEUROINFECTION. 2022: 27; 52-55.

    5. 令和3年度

  5. *佐久間啓. FIRES (Febrile infection-related epilepsy syndrome)：治療を中心に. Epilepsy. 2021;11:17-22.

    6. 令和2年度

  6. *Sakuma H, Horino A, Kuki I. Neurocritical care and target immunotherapy for febrile infection-related epilepsy syndrome. Biomed J. 2020;43:205-210.（査読あり）

    7. 平成30年度

  7. *佐久間啓. 自己免疫性大脳基底核障害と自己抗体. BRAIN and NERVE-神経研究の進歩. 2018; 70: 363-369.

    8. 平成29年度

  8. *佐久間啓. 中枢神経の感染症，免疫性疾患−亜急性・慢性疾患を中心に．乳幼児期発症神経疾患のファーストタッチから専門診療へ．小児科診療 2017: 86 : 321-326
  9. *佐久間啓. 難治頻回部分発作重積型急性脳炎．稀少てんかん診療指標 2017: 150-153.

    10. 平成28年度

  10. *佐久間啓. 急性散在性脳脊髄炎．小児疾患診療のための病態生理．小児内科 2016: 48増刊号; 358-61.

    11. 平成27年度

  11. *佐久間啓. 溶連菌感染と関連した自己免疫性神経疾患と抗大脳基底核抗体．増刊号「免疫性神経疾患」日本臨床 2015; 73増刊号7．
  12. *林雅晴. 正常発達を評価するポイント. 病理と臨床2015; 33(4): 373-379.
  13. *林雅晴. 進行性ミオクローヌスてんかん. 小児内科2015; 47(9): 1644-1648.

    14. 平成26年度

  14. *佐久間啓. 自己抗体と脳炎．炎症と免疫 2015; 23(2).
  15. 林雅晴. 良性家族性新生児けいれん・良性特発性新生児けいれん.小児科2014; 55(7): 1139-1143

    16. 平成25年度

  16. *佐久間啓. 難治頻回部分発作重積型急性脳炎をめぐる最近の話題．脳と発達 2013; 45(2): 110-114.
  17. *林雅晴. 病理所見からの重症心身障害の病態の理解. 日本重症心身障害学会誌 2013; 38(1): 19-25.
  18. *林雅晴. 抗大脳基底核抗体. BRAIN and NERVE 2013; 65(4): 377-384.
  19. *田沼直之、林雅晴．エダラボン．小児内科2013; 45(2): 253-256.
  20. *林雅晴. 脳炎・脳症・髄膜炎の病理所見からわかること. 小児内科2013; 45(2): 191-194.

    21. 平成24年度

  21. *Hayashi M, Nakajima K, Miyata R, Tanuma N, Kodama T. Lesion of acetylcholine neurons in refractory epilepsy. In: ISRN Neurology (ISSN: 2090-5513 doi:10.5402/NEUROLOGY). Hindawi Publishing Corporation, Volume 2012, Article ID 404263. doi:10.5402/2012/404263.（査読有）
  22. *Hayashi M, Tanuma N, Miyata R. Oxidative stress in developmental brain disorders. In: Ahmad S, eds. Neurodegenerative diseases. Adv Exp Med Biol 2012; 724: 278-290.
  23. 松岡貴子，*佐久間啓. 神経疾患と免疫. 小児内科2012; 44: 1416-1422.

    24. 平成23年度

  24. *林雅晴. 色素性乾皮症の神経病変. Visual Dermatology 2011; 10(5):456-458.
  25. *林雅晴. けいれんの機序と病態. 小児内科2011; 43(3): 359-363.
  26. *佐久間啓．粟屋福山症候群．小児科診療 2011; 74: 986-90
  27. *佐久間啓．特異な脳炎・脳症後てんかんの一群(福山-粟屋).小児内科 2011; 43: 506-508.

    28. 平成22年度

  28. *林雅晴. 難治性てんかんの神経病理. 日本小児臨床薬理学会雑誌2010; 23(1): 17-22.
  29. *佐久間啓. 小児の自己免疫性神経疾患　脳炎を中心に 日本小児科学会雑誌 2010; 114: 1665-72.

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