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Development of Stem Cell-based Blood Regeneration Techniques for Cancer Therapy

Project Leader Takahiko Hara

Takahiko Hara

Selected Publications

  • Tanegashima K, Takahashi R, Nuriya H, Iwase R, Naruse N, Tsuji K, Shigenaga A, Otaka A, and Hara T. (2017) “CXCL14 acts as a specific carrier of CpG DNA into dendritic cells and activates Toll-like receptor 9-mediated adaptive immunity.” EBioMed. 24: 247-256.
  • Tanegashima K, Sato-Miyata Y, Funakoshi M, Nishito Y, Aigaki T, and Hara T. (2017) “Epigenetic regulation of the glucose transporter gene Slc2a1 by -hydroxybutyrate underlies preferential glucose supply to the brain of fasted mice.” Genes Cells 22: 71-83.
  • Suzuki T, Kazuki Y, Oshimura M, and Hara T. (2016) “Highly efficient transfer of chromosomes to a broad range of target cells using Chinese hamster ovary cells expressing murine leukemia virus-derived envelope proteins. PLoS ONE 11: e0157187.
  • Kodaka Y, Tanaka K, Kitajima, Tanegashima K, Matsuda R, and Hara T.(2015) “LIM homeobox transcription factor Lhx2 inhibits skeletal muscle differentiation in part via transcriptional activation of Msx1 and Msx2. ” Exp. Cell Res. 331: 309-319.
  • Tanaka K, Kondo K, Kitajima K, Muraoka M, Nozawa A, and Hara T. (2013) “Tumor-suppressive function of protein-tyrosine phosphatase non-receptor type 23 in testicular germ cell tumors is lost upon overexpression of miR142-3p microRNA.” J. Biol. Chem. • 288: 23990-23999.
  • Kitajima K, Minehata K, Sakimura K, Nakano T, and Hara T. (2011) “In vitro generation of HSC-like cells from murine ESCs/iPSCs by enforced expression of LIM-homeobox transcription factor Lhx2.” Blood 117: 3748-3758.