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Laboratory of Protein Metabolism
Laboratory Head
Yasushi Saeki
Selected Publication
- Tsuchiya, H., Ohtake, F., Arai, N., Kaiho, A., Yasuda, S., Tanaka, K., and Saeki, Y. (2017) “In vivo ubiquitin linkage-type analysis reveals that the Cdc48-Rad23/Dsk2 axis contributes to K48-linked chain specificity of the proteasome.” Mol. Cell 66, 485-502.
- Ohtake, F., Saeki, Y., Ishido, S., Kanno, J., and Tanaka , K. (2016) “The K48-K63 branched ubiquitin chain regulates NF-κB signaling.” Mol. Cell 64, 251-266.
- Yoshida, Y., Yasushi Saeki, Y., Murakami, A., Kawawaki, J., Tsuchiya, H., Yoshihara, H., Shindo, M., and Tanaka, K. (2015) “A comprehensive method for detecting ubiquitinated substrates using TR-TUBE.” Proc. Natl. Acad. Sci. USA. 112, 4630-4635.
- Pack, Chan-Gi., Yukii, H., Toh-e, A., Kudo, T., Tsuchiya, H., Kaiho, A., Sakata, E., Murata, S., Yokosawa, H., Sako, Y., Baumeister, W., Tanaka, K., and Saeki, Y. (2014) “Quantitative live-cell imaging reveals molecular dynamics and cytoplasmic assembly of the 26S proteasome.” Nature Commun. 5, 4396
- Koyano, F., Okatsu, K., Kosako, H., Tamura, Y., Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T., Endo, T., Fon. E.A., Trempe, J.F., Saeki, Y., Tanaka, K., and Matsuda, N. (2014) “Ubiquitin is phosphorylated by PINK1 to activate parkin.” Nature 510,162-166.
- Saeki, Y., Toh-e, A., Kudo, T., Kawamura, H., and Tanaka, K. (2009) “Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particle.” Cell 137, 900-913.
- Murata, S., Sasaki, K., Kishimoto, T., Niwa, S., Hayashi, H., Takahama, Y., and Tanaka, K. (2007) “Regulation of CD8+ T cell development by thymus-specific proteasomes.” Science 316, 1349-1353.
- Hirano, Y., Hendil, K.B., Yashiroda, H., Iemura, S., Nagane, R., Hioki, Y., Natsume, T., Tanaka, K., and Murata, S. (2005) “A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes.” Nature 437, 1381-1385.