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9 Dec 2021
Masato Hasegawa (Dementia Research Project) collaborated with Benjamin Ryskeldi-Falcon, Group Leader of MRC Laboratory of Molecular Biology and Professor Mari Yoshida of Aichi Medical University to publish an article ”Structure of pathological TDP-43 filaments from ALS with FTLD” in Nature.

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Structural breakthrough in study of aggregated TDP-43 protein in brains of ALS and FTD sufferers

<Title of the paper>
Structure of pathological TDP-43 filaments from ALS with FTLD
<Authors>
Diana Arseni(MRC Laboratory of Molecular Biology, Cambridge, UK)
Masato Hasegawa(Department of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan)
Alexey G. MurzinM(MRC Laboratory of Molecular Biology, Cambridge, UK)
Fuyuki Kametani(Department of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan)
Makoto Arai(Department of Psychiatry and Behavioural Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan)
Mari Yoshida(Institute for Medical Science of Aging, Aichi Medical University, Aichi, Japan)
Benjamin Ryskeldi-Falcon(MRC Laboratory of Molecular Biology, Cambridge, UK)
<Journal>
Nature
DOI:10.1038/s41586-021-04199-3.
URL:https://www.nature.com/articles/s41586-021-04199-3
Structure of pathological TDP-43 filaments from ALS with FTLD
Structure of pathological TDP-43 filaments from ALS with FTLD

A. Immunostaining of phosphorylated TDP-43 in ALSD (motor cortex),
B. Immunostaining of phosphorylated TDP-43 in ALSD (spinal cord),
C. Immunoelectron EM images of TDP-43 filaments isolated from ALSD brain (labeled with an anti-TDP-43 antibody (pS409/410) with 10nm-gold particle),
D. Cryo-EM map of TDP-43 filaments from ALSD brain,
E. Density map of TDP-43 filaments by cryo-EM,
F. Atomic model of the structure of TDP-43 filaments from ALSD brain

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