研究業績

• 業績
• 受賞

業績

• Kosuke Tanegashima, Eiji Esashi, Koji Ishida, Ayumi Kotaki, Rina Iwase, Manaka Hasebe, Rena Takahashi, Risa Saito, Yasuhiro Kazuki, Teruhiko Suzuki, Takahiko Hara: CXCL14 is an essential modulator of TLR9 agonist-induced antitumor immune responses. J. Immunol.2025 (doi: 10.1093/jimmun/vkaf080.)
• Teruhiko Suzuki, Satoko Takagi, Junta Funada, Yuka Egawa, Mana Yamakawa, Takahiko Hara: DDX1 is required for non-spliceosomal splicing of tRNAs but not of XBP1 mRNA. Commun. Biol. 8, 92, 2025 (doi: 10.1038/s42003-025-07523-z)
• Masaya Egawa, Narumi Uno, Rina Komazaki, Yusuke Ohkame, Kyotaro Yamazaki, Chihiro Yoshimatsu, Yuki Ishizu, Yusaku Okano, Hitomaru Miyamoto, Mitsuhiko Osaki, Teruhiko Suzuki, Kazuyoshi Hosomichi, Yasunori Aizawa, Yasuhiro Kazuki, and Kazuma Tomizuka: Generation of monosomy 21q human iPS cells by CRISPR/Cas9-mediated interstitial megabase deletion. Genes to cells 30:e13184, 2025 (doi: 10.1111/gtc.13184)
• Narumi Uno, Hitomaru Miyamoto, Kyotaro Yamazaki, Masaya Egawa, Hiroaki Kobayashi, Kanako Kazuki, Mitsuhiko Osaki, Teruhiko Suzuki, Shusei Hamamichi, Mitsuo Oshimura, Kazuma Tomizuka, Yasuhiro Kazuki: Microcell-mediated chromosome transfer between non-identical human iPSCs. Molecular Therapy: Nucleic Acid. 35(4): 102382, 2024 (doi: 10.1016/j.omtn.2024.102382)
• Narumi Uno, Hiroyuki Satofuka, Hitomaru Miyamoto, Kazuhisa Honma, Teruhiko Suzuki, Kyotaro Yamazaki, Ryota Ito, Takashi Moriwaki, Shusei Hamamichi, Kazuma Tomizuka, Mitsuo Oshimura, Yasuhiro Kazuki: Treatment of CHO cells with Taxol and reversine improves micronucleation and microcell-mediated chromosome transfer efficiency. Molecular Therapy: Nucleic Acid. 2023 33:391-403. (doi: 10.1016/j.omtn.2023.07.002.)
• Kyotaro Yamazaki, Kyosuke Matsuo, Akane Okada, Narumi Uno, Teruhiko Suzuki, Satoshi Abe, Shusei Hamamichi, Nanami Kishima, Shota Togai, Kazuma Tomizuka, Yasuhiro Kazuki: Simultaneous loading of PCR-based multiple fragments on mouse artificial chromosome vectors in DT40 cell for gene delivery. Sci. rep. 2022 16;12(1):21790. (doi: 10.1038/s41598-022-25959-9.)
• Teruhiko Suzuki, Satoko Takagi, and Takahiko Hara: Multiple Gene Transfer and All-in-one Conditional Knockout Systems in Mouse Embryonic Stem Cells for Analysis of Gene Function. Front Cell Dev Biol. 10:870629, 2022 (doi: 10.3389/fcell.2022.870629)
• Narumi Uno, Shuta Takata, Shinya Komoto, Hitomaru Miyamoto, Yuji Nakayaka, Mitsuhiko Osaki, Ryota Mayuzumi, Natsumi Miyazaki, Chiaki Hando, Satoshi Abe, Tetsushi Sakuma, Takashi Yamamoto, Teruhiko Suzuki, Yoshihiro Nakajima, Mitsuo Oshimura, Kazuma Tomizuka & Yasuhiro Kazuki: Panel of human cell lines with human/mouse artificial chromosomes. Sci. rep. 2022 Feb 22;12(1):3009. (doi: 10.1038/s41598-022-06814-3)
• Satoshi Abe, Kazuhisa Honma, Akane Okada, Kanako Kazuki, Hiroshi Tanaka, Takeshi Endo, Kayoko Morimoto, Takashi Moriwaki, Shusei Hamamichi, Yuji Nakayama, Teruhiko Suzuki, Shoko Takehara, Mitsuo Oshimura, Yasuhiro Kazuki: Construction of stable mouse artificial chromosome from native mouse chromosome 10 for generation of transchromosomic mice. Sci. rep. 2021 Oct 8;11(1):20050. (doi: 10.1038/s41598-021-99535-y)
• Teruhiko Suzuki, Eiji Katada, Yuki Mizuoka, Satoko Takagi, Yasuhiro Kazuki, Mitsuo Oshimura, Mayumi Shindo, Takahiko Hara: A novel all-in-one conditional knockout system uncovered an essential role of DDX1 in ribosomal RNA processing. Nucleic Acids Res. 49(7): e40, 2021 (doi: 10.1093/nar/gkaa1296)
• Teruhiko Suzuki, Yasuhiro Kazuki, Takahiko Hara, Mitsuo Oshimura: Current advances in microcell-mediated chromosome transfer technology and its applications. Exp. Cell Res. 390(1):111915, 2020 (doi: 10.1016/j.yexcr.2020.111915)
• Marianna Paulis, Lucia Susani, Alessandra Castelli, Teruhiko Suzuki, Takahiko Hara, Letizia Straniero, Stefano Duga, Dario Strina, Stefano Mantero, Elena Caldana, Lucia Sergi Sergi, Anna Villa, Paolo Vezzoni: Chromosome transplantation: a possible approach to treat human X-linked disorders. Mol. Ther. Methods Clin. Dev. 17:369-377, 2020 (doi: 10.1016/j.omtm.2020.01.003)
• 月刊「細胞」2020年 7月号 染色体導入法の原理と技術改良（鈴木 輝彦・原 孝彦）
• Marino Nakajima, Teruhiko Suzuki, Takahiko Hara, Kenji Kitajima: In vitro differentiation of mouse T cell-derived hybrid cells obtained through cell fusion with embryonic stem cells. Biochemical and Biophysical Research Communications. 4;513(3):701-707, 2019 (doi: 10.1016/j.bbrc.2019.04.038.)
• Narumi Uno, Tomohito Fujimoto, Shinya Komoto, Gene Kurosawa, Masaaki Sawa, Teruhiko Suzuki, Yasuhiro Kazuki, Mitsuo Oshimura: A luciferase complementation assay system using transferable mouse artificial chromosomes to monitor protein-protein interactions mediated by G protein-coupled receptors. Cytotechnology. 70(6):1499-1508, 2018 (doi: 10.1007/s10616-018-0231-7)
• Takashi Shinohara, Kanako Kazuki, Narumi Ogonuki, Hiroko Morimoto, Shogo Matoba, Kei Hiramatsu, Kazuhisa Honma, Teruhiko Suzuki, Takahiko Hara, Atsuo Ogura, Mitsuo Oshimura, Mito Kanatsu-Shinohara, and Yasuhiro Kazuki: Transfer of a Mouse Artificial Chromosome into Spermatogonial Stem Cells Generates Transchromosomic Mice. Stem Cell Reports. 9(4):1180-1191, 2017 (doi: 10.1016/j.stemcr.2017.08.012)
• Teruhiko Suzuki, Yasuhiro Kazuki, Mitsuo Oshimura, and Takahiko Hara: Highly Efficient Transfer of Chromosomes to a Broad Range of Target Cells Using Chinese Hamster Ovary Cells Expressing Murine Leukemia Virus-Derived Envelope Proteins. PLoS One. 11(6): e0157187, 2016 (doi:10.1371/journal.pone.0157187)
• Narumi Uno, Katsuhiro Uno, Shinya Komoto, Teruhiko Suzuki, Masaharu Hiratsuka, Mitsuhiko Osaki, Yasuhiro Kazuki, Mitsuo Oshimura: Development of a Safeguard System Using an Episomal Mammalian Artificial Chromosome for Gene and Cell Therapy. Mol. Ther. Nucleic Acids. e272, 2015 (doi: 10.1038/mtna.2015.45)
• Elena M. Pugacheva, Samuel Rivero-Hinojosa, Celso A. Espinoza, Claudia Fabiola Méndez-Catalá, Sungyun Kang, Teruhiko Suzuki, Natsuki Kosaka-Suzuki, Susan Robinson, Vijayaraj Nagarajan, Zhen Ye, Abdelhalim Boukaba, John E. J. Rasko, Alexander V. Strunnikov, Dmitri Loukinov, Bing Ren, Victor V. Lobanenkov: Comparative analyses of CTCF and BORIS occupancies uncover two distinct classes of CTCF binding genomic regions. Genome Biology. 16:161, 2015 (doi: 10.1186/s13059-015-0736-8)
• Tsunaki Hongu, Yuji Funakoshi, Shigetomo Fukuhara, Teruhiko Suzuki, Susumu Sakimoto, Nobuyuki Takakura, Masatsugu Ema, Satoru Takahashi, Susumu Itoh, Mitsuyasu Kato, Hiroshi Hasegawa, Naoki Mochizuki & Yasunori Kanaho: Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial β1 integrin recycling. Nat. Commun. 6: 7925, 2015 (doi: 10.1038/ncomms8925)
• Takuya Miyazaki, Yong-Soo Kim, Jeongheon Yoon, Hongsheng Wang, Teruhiko Suzuki, Herbert C. Morse III: The 3'-5' DNA exonuclease TREX1 directly interacts with Poly(ADP-ribose) Polymerase-1 (PARP1) during the DNA damage response. J Biol Chem. 289(47):32548-58, 2014 (doi: 10.1074/jbc.M114.547331)
• Teruhiko Suzuki, Yasuhiro Kazuki, Mitsuo Oshimura, and Takahiko Hara: A novel system for simultaneous or sequential integration of multiple gene-loading vectors into a defined site of a human artificial chromosome. PLoS One. 9(10): e110404, 2014 (doi: 10.1371/journal.pone.0110404)
• Natsuki Kosaka-Suzuki*, Teruhiko Suzuki*, Elena M Pugacheva, Alexander A Vostrov, Herbert C Morse 3rd, Dmitri Loukinov, and Victor Lobanenkov: Transcription factor BORIS (brother of the regulator of imprinted sites) directly induces expression of a cancer-testis antigen, TSP50, through regulated binding of BORIS to the promoter. J. Biol. Chem. 286(31): 27378-27388, 2011 (doi: 10.1074/jbc.M111.243576) *Equally contributing authors.
• Elena M. Pugacheva, Teruhiko Suzuki, Svetlana Pack, Natsuki Kosaka-Suzuki, Alex Vostrov, Eugene Barsov, Alexander Strunnikov, Herbert C. Morse III, Dmitri Loukinov, Victor Lobanenkov: The structural complexity of the human BORIS gene in gametogenesis and cancer. PLoS One 5(11): e13872, 2010 (doi: 10.1371/journal.pone.0013872)
• Atsushi Suzuki, Chihiro Arikawa, Yuji Kuwahara, Koh-ichi Itoh, Masatomo Watanabe, Hiroshi Watanabe, Teruhiko Suzuki, Yuji Funakoshi, Hiroshi Hasegawa, Yasunori Kanaho: The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons. FEBS lett. 584: 2801-2806, 2010 (doi: 10.1016/j.febslet.2010.05.020)
• Teruhiko Suzuki, Natsuki Kosaka-Suzuki, Svetlana Pack, Dong-Mi Shin, Jeongheon Yoon, Ziedulla Abdullaev, Elena Pugacheva, Herbert C. Morse III, Dmitri Loukinov, Victor Lobanenkov: Expression of a testis-specific form of Gal3st1 (CST), a gene essential for spermatogenesis, is regulated by the CTCF paralogous gene BORIS. Mol. Cell. Biol. 30: 2473-2484, 2010 (doi: 10.1128/MCB.01093-09)
• Teruhiko Suzuki, Yoshiakira Kanai, Takahiko Hara, Junko Sasaki, Takehiko Sasaki, Michinori Kohara, Tomohiko Maehama, Choji Taya, Hiroshi Shitara, Hiromichi Yonekawa, Michael A. Frohman, Takeaki Yokozeki, Yasunori Kanaho: Crucial role of the small GTPase ARF6 in hepatic cord formation for liver development. Mol. Cell. Biol. 26: 6149-6156, 2006 (doi: 10.1128/MCB.00298-06)
• Yasunori Kanaho, Teruhiko Suzuki: Phosphoinositide kinases as enzymes that produce versatile signaling lipids, phosphoinositides. J. Biochem. 131: 503-509, 2002 (doi: 10.1093/oxfordjournals.jbchem.a003127)

Page Top

受賞

• 第53回日本免疫学会学術集会 ベストプレゼンテーション賞
• 2024年度 所内研究発表会第１部会優秀発表賞
• 2021年度 東京都医学総合研究所職員表彰
• 2021年度 所内研究発表会第１部会優秀発表賞