2024年9月27日
井口研究員、宮武客員研究員によるGATA3変異マウスに関する論文がGenes to Cellsにアクセプトされました。
Title: Loss of a single Zn finger, but not that of two Zn fingers, of GATA3 drives skin inflammation
Authors: Iguchi, Tomohiro; Toma-Hirano, Makiko; Takanashi, Masakatsu; Masai, Hisao; Miyatake, Shoichiro
本論文では、GATA3 single Zn-fingerの欠損マウスは、既知の２個のZn-fingerを欠損するマウスとは異なり、皮膚炎症の症状を呈することを初めて示しました。
2024年8月23日
鷺さん、加納研究員のRNA-DNA hybridに関する論文がGenes to Cellsにアクセプトされました・
Title: RNA-DNA hybrids on protein coding genes are stabilized by loss of RNase H and are associated with DNA damages during S-phase in fission yeast.
Authors: Tomoko Sagi, Daichi Sadato, Kazuto Takayasu, Hiroyuki Sasanuma, Yutaka Kanoh, Hisao Masai
本論文では、分裂酵母のRNA-DNA hybridのprofileの解析とそのDNA損傷との関連を明らかにしました。
論文はこちらから。
2024年7月26日
デンマークのGenevieve Thon教授、Groth 教授らとの共同研究により、Mrc1のヒストン分配における重要な役割を解明し、下記のCell誌に発表した。
Charlton SJ, Flury V, Kanoh Y, Genzor AV, Kollenstart L, Ao W, Brøgger P, Weisser MB, Adamus M, Alcaraz N, Delvaux de Fenffe CM, Mattiroli F, Montoya G, Masai H, Groth A, Thon G. The fork protection complex promotes parental histone recycling and epigenetic memory. Cell. 2024 Jul 26:S0092-8674(24)00777-3. doi: 10.1016/j.cell.2024.07.017. Epub ahead of print. PMID: 39094569.
Title: “Water-Soluble Mn(III)-Porphyrins with High Relaxivity and Photosensitization”
Author(s): Nemeth, Tamas; Pallier, Agnes; Çelik, Çetin; garda, zoltan; Yoshizawa-Sugata, Naoko; Masai, Hisao; Tóth, Éva; Yamakoshi, Yoko
ABSTRACT: Three water-soluble Mn(III)-porphyrin complexes with cationic pyridyl side groups bearing COOH- or OH-terminated carbon chains in the meta or para positions have been synthesized as probes for both magnetic resonance imaging (MRI) and photodynamic therapy (PDT). The complexes Mn-1, Mn-2, and Mn-3 are highly water-soluble, and their relaxivities range between 10-15 mM-1s-1, at 20-80 MHz and 298K, 2-3 times higher than that of commercial Gd(III)-based agents. The complexes containing carboxylate (Mn-2) or alcoholic (Mn-3) side chains in para position are endowed with higher relaxivities and have also shown efficient photoinduced DNA cleavage and singlet oxygen (1O2) generation. Mn-3 with stronger photoinduced DNA cleavage has also revealed stabilizing and binding activities for G4 DNA, at a similar level as the known G4 binder Mn-TMPyP4. Nevertheless, the G4-binding activity of Mn-3 was non-specific. Preliminary tests evidenced photocytotoxicity of Mn-3 on HeLa cells without significant effect in the absence of light. Altogether, these results underline the potential of such water-soluble Mn(III)-porphyrins for the development of multimodal approaches combining MRI and PDT.
2024年8月14日
Zhiying You 研究員のMCMについての総説（Assembly, activation and helicase actions of MCM）がBiology誌にアクセプトされました。これは、Peter J. Gillespie博士（Cancer Research UK Chromosome Replication)が企画したReplication Licensing and MCM2-7 functionに関する特集号です。
総説のpreprintはここからダウンロードできます。
