Our Team

わたしたちについて

ゲノム不安定性は、がんに共通した特性です。ゲノム不安定性を引き起こす原因として、DNA複製やDNA 損傷修復の異常が挙げられます。私たちは、DNA損傷修復のメカニズムとその破綻が引き起こす疾患の発症メカニズムの解明に興味があります。
私たちの研究に興味がある人はぜひ連絡をください。

Project Leader

笹沼博之
Hiroyuki Sasanuma

プロジェクトリーダー

mail：sasanuma-hr

Hiroyuki’s research focuses on the molecular mechanisms involved in the repair of DNA double-strand breaks. He uses yeast, human cell lines, and mice as model organisms. He currently conducts experiments both at the bench and in the culture room, similar to a postdoctoral researcher. Hiroyuki is particularly interested in developing new therapies to cure cancer. His hobbies include reading books and listening to music. He also loves skiing and visits the Zao Ski Resort in Yamagata alone every year.

参事研究員

正井久雄
Hisao Masai

mail：masai-hs

過去の情報はこちらからご覧ください

研究員

北島健二
Kenji Kitajima

種子島幸祐
Kosuke Tanegashima

平井隼人
Hayato Hirai

山田真太郎
Shintaro Yamada

Shintaro Yamada wants to understand how cells repair DNA efficiently. Radiation and other naturally occurring exogenous and endogenous DNA damaging agents often generate genomic DNA breaks with chemically modified DNA ends that are highly carcinogenic. Cleaning the modified DNA ends is a critical step of DNA repair, but much remains unknown about its molecular mechanism. To understand this process, Yamada is developing high-resolution methods and examining how DNA repair machinery works at DNA break ends and prevents cancer-causing genetic mutations in human cells.

加納豊
Yutaka Kanoh

井口智弘
Tomohiro Iguchi

高井裕子
Zhiying You

DNA複製ヘリカーゼMCMと複製フォーク安定化因子Claspinタンパク質のDNA複製の開始と進行における機能解析という課題に取り組んでいます。最近Claspinのリン酸化による複製フォーク複合体の活性制御の解明を目指して研究しています。
趣味は音楽鑑賞と旅行です。

田中卓
Taku Tanaka

田島陽一
Youichi Tajima

柴田武彦
Takehiko Shibata

外部支援研究員

伊藤さゆり
Sayuri Ito

Ngô Thị Tố Trinh
NGO THI TO TRINH

（D4, Ochanomizu Univ.）

Trinh's research focuses on Topoisomerase proteins and their contribution to cancer, as well as their activities on the genome. She wants to explore the mysteries of this world through the eye of science, which is why she chose to become a scientist. Her hobbies vary based on her emotions.

鄭嵐心
Lanxin Zheng

（M2, The University of Tokyo）

I am interested in exploring the biology field to answer three questions: What will happen? How will it happen? And how will it influence our body? Beyond the lab, I enjoy hiking, playing badminton, and photography. These activities not only provide a well-rounded balance to rigorous research but also inspire innovative approaches in my scientific endeavors.