品質管理プロジェクト

English 
研究成果

氏名の左に「＊」を付してあるのが、その論文の責任著者(Corresponding author)です。

2025

  • *Endo A, Takahashi C, Ishibashi N, Nishito Y, Yamano K, Tanaka K, *Yoshida Y.
    Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response.
    Elife doi: 10.7554/eLife.106901.2 .
  • *Okatsu K, Kikuchi R, Matsuda N, Fukai S, and *Yamano K.
    Functional and structural insight into complex formation between OPTN leucine zipper domain and RAB8A.
    Genes Cells 30(5):e70043. (2025) doi: 10.1111/gtc.70043 .
  • Watanabe A, Ogiwara S, Saito M, Mishima M, Yamashina M, Ishitani R, Ito Y, Tanaka K, Koyano F, Yamano K, Kosako H, *Moriwaki Y, and *Matsuda N.
    The reaction mechanism for glycolysis side product degradation by Parkinson’s disease–linked DJ-1.
    J. Cell Biol. 224(8): e202411078. (2025) doi: 10.1083/jcb.202411078 .
  • Hsu MC, Kinefuchi H, Lei L, Kikuchi R, *Yamano K, and *Youle RJ
    Mitochondrial YME1L1 governs unoccupied protein translocase channels
    Nat Cell Biol. 27(2):309-321.(2025) doi: 10.1038/s41556-024-01571-z .

2015 − 2024

  • *Koyano F, Yamano K, Hoshina T, Kosako H, Fujiki Y, Tanaka K, and *Matsuda N.
    AAA+ ATPase chaperone p97/VCPFAF2 governs basal pexophagy
    Nat Commun. 15(1): 9347 (2024) doi: 10.1038/s41467-024-53558-x.
  • Endo R, Kinefuchi H, Sawada M, Kikuchi R, Kojima W, Matsuda N, and *Yamano K.
    TBK1 adaptor AZI2/NAP1 regulates NDP52-driven mitochondrial autophagy.
    J. Biol. Chem. 300(10): 107775 (2024)
  • *Yamano K, Sawada M, Kikuchi R, Nagataki K, Kojima W, Endo R, Kinefuchi H, Sugihara A, Fujino T, Watanabe A, Tanaka K, Hayashi G, Murakami H, and Matsuda N.
    Optineurin provides a mitophagy contact site for TBK1 activation.
    EMBO J. 43(5), 754-779 (2024)
  • Watanabe A, Koyano F, Imai K, Hizukuri Y, Ogiwara S, Ito T, Miyamoto J, Shibuya C, Kimura M, Toriumi K, Motono C, Arai M, Tanaka K, Akiyama Y, Yamano K, and *Matsuda N.
    The origin of esterase activity of Parkinson's disease causative factor DJ-1 implied by evolutionary trace analysis of its prokaryotic homolog HchA.
    J. Biol. Chem. 300(7): 107476 (2024)
  • Cui M, Yamano K, Yamamoto K, Yamamoto-Imoto H, Minami S, Yamamoto T, Matsui S, Kaminishi T, Shima T, Ogura M, Tsuchiya M, Nishino K, Layden B, Kato H, Ogawa H, Oki S, Okada Y, Isaka Y, Kosako H, Matsuda N, Yoshimori T, and *Nakamura S.
    HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence.
    Proc. Natl. Acad. Sci. USA, 121(2): e2306454120 (2024).
  • Kurusu R, Fujimoto Y, Morishita H, Noshiro D, Takada S, Yamano K, Tanaka H, Arai R, Kageyama S, Funakoshi T, Komatsu-Hirota S, Taka H, Kazuno S, Miura Y, Koike M, Wakai T, Waguri S, Noda NN, and *Komatsu M.
    Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex.
    Dev. Cell 58(13): 1189-1205.e11 (2023)
  • Hayashida R, Kikuchi R, Imai K, Kojima W, Yamada T, Iijima M, Sesaki H, Tanaka K, *Matsuda N, and *Yamano K.
    Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid-liquid phase separation-based method.
    J. Biol. Chem. 299(2):102822 (2023)
  • #Queliconi BB, #Kojima W, Kimura M, Imai K, Udagawa C, Motono C, Hirokawa T, Tashiro S, Caaveiro JMM, Tsumoto K, Yamano K, Tanaka K, and *Matsuda N.
    Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1.
    J. Cell Science, 134(22):jcs258653 (2021). # equally contributed
  • Kojima W, *Yamano K, Kosako H, Imai K, Kikuchi R, Tanaka K, and Matsuda N.
    Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy.
    Autophagy, 17,2011-2036. (2021)
  • *Yamano K, Kikuchi R, Kojima W, Hayashida R, Koyano F, Kawawaki J, Shoda T, Demizu Y, Naito M, Tanaka K, and *Matsuda N.
    Critical Role of Mitochondrial Ubiquitination and the OPTN-ATG9A Axis in Mitophagy.
    J. Cell Biol., 219: e201912144 (2020), doi: 10.1083/jcb.201912144.
    Selected by Year in Cell Biology Collection 2020
  • Koyano F, Yamano K, Kosako H, Tanaka K, and *Matsuda N.
    Parkin recruitment to impaired mitochondria and unspecified ubiquitylation are facilitated by MITOL.
    J. Biol. Chem., 294, 10300-10314 (2019), doi: 10.1074/jbc.RA118.006302.
  • Koyano F, Yamano K, Kosako H, Kimura Y, Kimura M, Fujiki Y, Tanaka K, and *Matsuda N.
    Parkin-mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes.
    EMBO Rep., 20:e47728 (2019), doi: 10.15252/embr.201947728.
  • *Yamano K, Wang C, Sarraf SA, Münch C, Kikuchi R, Noda NN, Hizukuri Y, Kanemaki MT, Harper W, Tanaka K, *Matsuda N, and *Youle RJ.
    Endosomal Rab cycles regulate Parkin-mediated mitophagy.
    Elife, (2018) 7:e31326 (32 page), doi: 10.7554/eLife.31326.
  • Okatsu K, Sato Y, Yamano K, Matsuda N, Negishi L, Takahashi A, Yamagata A, Goto-Ito S, Mishima M, Ito Y, Oka T, Tanaka K, and *Fukai S.
    Structural insights into ubiquitin phosphorylation by PINK1.
    Scientific Reports, 8(1):10382 (2018)
  • *Matsuda N, Kimura M, Queliconi BB, Kojima W, Mishima M, Takagi K, Koyano F, Yamano K, Mizushima T, Ito Y, and *Tanaka K.
    Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro.
    Scientific Reports, 7(1):12816 (2017)
  • Sato Y, Okatsu K, Saeki Y, Yamano K, Matsuda N, Kaiho A, Yamagata A, Goto-Ito S, Ishikawa M, Hashimoto Y, Tanaka K, and *Fukai S.
    Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30.
    Nat. Struct. Mol. Biol. 24, 911-919 (2017) doi: 10.1038/nsmb.3469.
  • Izumikawa K, Nobe Y, Yoshikawa H, Ishikawa H, Miura Y, Nakayama H, Nonaka T, Hasegawa M, Egawa N, Inoue H, Nishikawa K, Yamano K, Simpson RJ, Taoka M, Yamauchi Y, Isobe T, and *Takahashi N.
    TDP-43 stabilises the processing intermediates of mitochondrial transcripts.
    Sci Rep. 7:7709 (2017) doi: 10.1038/s41598-017-06953-y.
  • Kojima W, Kujuro Y, Okatsu K, Queliconi BB, Koyano F, Kimura M, Yamano K, Tanaka K, and * Matsuda N.
    Unexpected mitochondrial matrix localization of Parkinson's disease-related DJ-1 mutants but not wild type DJ-1.
    Genes to Cells 21(7):772-88 (2016)
  • * Yamano K, Queliconi BB, Koyano F, Saeki Y, Hirokawa T, Tanaka K, and Matsuda N.
    Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation.
    J Biol Chem. 290: 25199-211 (2015)

氏名の左に「＊」を付してあるのが、その論文の責任著者(Corresponding author)です。

2016 − 2024

  • 山野 晃史
    ミトコンドリア選択的オートファジーの誘導と解析法
    実験医学別冊（羊土社）p205-215 (2024)
  • 田村 康, 山野 晃史
    疾患研究につながるオルガネラ実験必携プロトコール
    実験医学別冊（羊土社）編集 (2024)
  • *Yamano K, Kinefuchi H, Kojima W.
    Mitochondrial lipid dynamics regulated by MITOL-mediated ubiquitination.
    J. Biochem. 175(3), 217-219 (2024)
  • *Yamano K, Kinefuchi H, Kojima W.
    Mitochondrial quality control via organelle and protein degradation.
    J. Biochem. 175, 487-494 (2024)
  • 山野 晃史
    選択的オートファジーによるオルガネラ分解
    実験医学（羊土社）Vol. 41, No. 12, p99-105 (2023)
  • *Yamano K, Kojima W.
    Molecular functions of autophagy adaptors upon ubiquitin-driven mitophagy.
    Biochim. Biophys. Acta., 292(8):3201-3212. (2021)
  • #Ohnishi M, #Yamano K, *Sato M, *Matsuda N, and *Okamoto K.
    Molecular mechanisms and physiological functions of mitophagy.
    MBO J. 40(3):e104705. (2021) # equally contributed
  • *Yamano K, Youle RJ.
    Two different axes CALCOCO2-RB1CC1 and OPTN-ATG9A initiate PRKN-mediated mitophagy.
    Autophagy. 16, 2105-2107 (2020)
  • *Matsuda N, Yamano K.
    Two sides of a coin: physiological significance and molecular mechanisms for damage-induced mitochondrial localization of PINK1 and Parkin.
    Neurosci. Res. S0168-0102(20)30171-1 (2020)
  • 山野 晃史
    不良ミトコンドリア選択的オートファジーの分子基盤
    BIO Clinica（北隆館）Vol. 35, No. 12, p62-67 (2020)
  • 山野 晃史
    不良ミトコンドリア分解を司るParkinとPINK1
    ファルマシア（公益財団法人 日本薬学会）Vol. 56, No. 1, p16-20 (2020)
  • 山野 晃史
    マイトファジー：損傷ミトコンドリアの選択的分解
    DOJIN NEWS（株式会社 同仁化学研究所）No. 171, p1-4 (2019)
  • 山野 晃史
    損傷ミトコンドリアの選択的分解
    生化学（公益社団法人 日本生化学会）Vol.91, No.3, p369-379 (2019)
  • *Yamano K, Lazarou M.
    YoungMito 2018: Report on the 1st International Mitochondria Meeting for Young Scientists.
    Genes Cells 23, 822-827 (2018)
  • 松田 憲之, 山野 晃史
    マイトファジー　PINK1とParkinによるミトコンドリア蛋白質の品質管理
    医学のあゆみ 医歯薬出版267巻13号, page1056-1062 (2018)
  • 山野 晃史
    マイトファジー：Parkin/PINK1によるダメージ認識とユビキチン化
    実験医学,羊土社,Vol. 35, No11, page 1794-1799 (2017)
  • 小島和華、*松田憲之
    ミトコンドリアクオリティコントロールとパーキンソン病 - 特に DJ-1 に着目して –
    脳21，金芳堂, Vol. 19, No. 3, pp13-20 (2016)
  • * Yamano K, Matsuda N, Tanaka K. The ubiquitin signal and autophagy
    an orchestrated dance leading to mitochondrial degradation.
    EMBO reports 17: 300-316 (2016)

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