研究成果

発表論文および総説

※表記は PubMed に準規しています。

  1. Comparative experience shapes sucrose preference through memory in Drosophila
    Maximiliano Martinez-Cordera, Takaomi Sakai, Minoru Saitoe, Kohei Ueno
    Mol Brain. (2025); 18(1):32.
    DOI：https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-025-01202-0
    PubMed：https://pubmed.ncbi.nlm.nih.gov/40211246/
  2. Behavioral Dysfunctions Caused by Pyridoxamine Deficiency in Drosophila melanogaster.
    Kohei Ueno, Izumi Nohara, Mitsuhiro Miyashita, Masanari Itokawa, Haruo Okado, Makoto Arai, Minoru Saitoe
    J Nutr Sci Vitaminol (Tokyo). (2024); 70(3):252-261.
    DOI：https://doi.org/10.3177/jnsv.70.252
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/38945891
  3. Glia transmit negative valence information during aversive learning in Drosophila
    Tomoyuki Miyashita, Kanako Murakami, Emi Kikuchi, Kyouko Ofusa, Kyohei Mikami, Kentaro Endo, Takaaki Miyaji, Sawako Moriyama, Kotaro Konno, Hinako Muratani, Yoshinori Moriyama, Masahiko Watanabe, Junjiro Horiuchi, Minoru Saitoe
    Science. (2023); 382(6677):eadf7429.
    DOI：https://doi.org/10.1126/science.adf7429
    PubMed：https://pubmed.ncbi.nlm.nih.gov/38127757/
    URL：https://www.science.org/doi/pdf/10.1126/science.adf7429
  4. Differential second messenger signaling via dopamine neurons bidirectionally regulates memory retention
    Mai Takakura, Yu Hong Lam, Reiko Nakagawa, Man Yung Ng, Xinyue Hu, Priyanshu Bhargava, Abdalla G Alia, Yuzhe Gu, Zigao Wang, Takeshi Ota, Yoko Kimura, Nao Morimoto, Fumitaka Osakada, Ah Young Lee, Danny Leung, Tomoyuki Miyashita, Juan Du, Hiroyuki Okuno, Yukinori Hirano
    PNAS. (2023); 120(36):e2304851120.
    DOI：https://doi.org/10.1073/pnas.2304851120
    PubMed：https://pubmed.ncbi.nlm.nih.gov/37639608/
  5. A Drosophila model of diabetic neuropathy reveals a role of proteasome activity in the glia
    Mari Suzuki, Hiroshi Kuromi, Mayumi Shindo, Nozomi Sakata, Naoko Niimi, Koji Fukui, Minoru Saitoe, Kazunori Sango
    iScience (2023); 26(6):106997.
    DOI：https://doi.org/10.1101/2022.09.22.509008
    PubMed：https://pubmed.ncbi.nlm.nih.gov/37378316/
  6. Dopamine activity in projection neurons regulates short-lasting olfactory approach memory in Drosophila
    Shintaro Naganos, Kohei Ueno, Junjiro Horiuchi, Minoru Saitoe
    Eur J Neurosci. (2022); 56(5):4558-4571.
    DOI：https://doi.org/10.1111/ejn.15766
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/35815601
  7. A non-canonical on-demand dopaminergic transmission underlying olfactory aversive learning
    Minoru Saitoe, Shintaro Naganos, Tomoyuki Miyashita, Motomi Matsuno, Kohei Ueno
    Neurosci Res. (2022); 178:1-9.
    DOI：https://doi.org/10.1016/j.neures.2021.12.008
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/34973292
  8. 糖尿病性神経障害モデルショウジョウバエにおけるグリア細胞プロテオスタシスの役割
    鈴木 マリ, 黒見 坦, 進藤 真由美, 新見 直子, 齊藤 実, 三五 一憲
    日本病態生理学会雑誌 (2021); 30(2) 47-47
  9. Ligand-Directed Approach to Activity-Based Sensing: Developing Palladacycle Fluorescent Probes That Enable Endogenous Carbon Monoxide Detection
    Johannes Morstein, Denis Höfler, Kohei Ueno, Jonah W Jurss, Ryan R Walvoord, Kevin J Bruemmer, Samir P Rezgui, Thomas F Brewer, Minoru Saitoe, Brian W Michel, Christopher J Chang
    J Am Chem Soc. (2020); 142(37):15917-15930.
    DOI：https://doi.org/10.1021/jacs.0c06405
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/32872768
  10. Carbon Monoxide, a Retrograde Messenger Generated in Postsynaptic Mushroom Body Neurons, Evokes Noncanonical Dopamine Release
    Kohei Ueno, Johannes Morstein, Kyoko Ofusa, Shintaro Naganos, Ema Suzuki-Sawano, Saika Minegishi, Samir P. Rezgui, Hiroaki Kitagishi, Brian W. Michel, Christopher J. Chang, Junjiro Horiuchi, Minoru Saitoe
    J Neurosci. (2020); 40(18):3533-3548.
    DOI：https://doi.org/10.1523/jneurosci.2378-19.2020
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/32253360
  11. Extracellular ADP augments microglial inflammasome and NF-κB activation via the P2Y12 receptor
    Tomonori Suzuki, Kuniko Kohyama, Kengo Moriyama, Mariko Ozaki, Setsuko Hasegawa, Taro Ueno, Minoru Saitoe, Tomohiro Morio, Masaharu Hayashi, Hiroshi Sakuma
    Eur J Immunol. (2020); 50(2):205-219.
    DOI：https://doi.org/10.1002/eji.201848013
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/31549730
  12. Dopamine modulates the optomotor response to unreliable visual stimuli in Drosophila melanogaster
    Masumi Akiba, Kentaro Sugimoto, Risa Aoki, Ryo Murakami, Tomoyuki Miyashita, Riho Hashimoto, Anna Hiranuma, Junji Yamauchi, Taro Ueno, Takako Morimoto
    Eur J Neurosci. (2020); 51(3):822-839.
    DOI：https://doi.org/10.1111/ejn.14648
    PubMed：https://pubmed.ncbi.nlm.nih.gov/31834948/
  13. Inhibiting Glutamate Activity during Consolidation Suppresses Age-Related Long-Term Memory Impairment in Drosophila
    Motomi Matsuno, Junjiro Horiuchi, Kyoko Ofusa, Tomoko Masuda, Minoru Saitoe
    iScience. (2019); 15:55-65.
    DOI：https://doi.org/10.1016/j.isci.2019.04.014
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/31030182
  14. Long-Term Memory Engram Cells Are Established by c-Fos/CREB Transcriptional Cycling
    Tomoyuki Miyashita, Emi Kikuchi, Junjiro Horiuchi, Minoru Saitoe
    Cell Rep. (2018); 25(10):2716-2728.e3.
    DOI：https://doi.org/10.1016/j.celrep.2018.11.022
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/30517860
  15. Synaptic depression induced by postsynaptic cAMP production in the Drosophila mushroom body calyx
    Shoma Sato, Kohei Ueno, Minoru Saitoe, Takaomi Sakai
    J Physiol. (2018); 596(12):2447-2461.
    DOI：https://doi.org/10.1113/JP275799
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/29659025
  16. A Drosophila ex vivo model of olfactory appetitive learning
    Ema Suzuki-Sawano, Kohei Ueno, Shintaro Naganos, Yoshihiro Sawano, Junjiro Horiuchi, Minoru Saitoe
    Sci Rep. (2017); 7(1):17725.
    DOI：https://doi.org/10.1038/s41598-017-17955-1
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/29255174
  17. Coincident postsynaptic activity gates presynaptic dopamine release to induce plasticity in Drosophila mushroom bodies
    Kohei Ueno, Ema Suzuki, Shintaro Naganos, Kyoko Ofusa, Junjiro Horiuchi, Minoru Saitoe
    Elife. (2017); 6:e21076.
    DOI：https://doi.org/10.7554/eLife.21076
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/28117664
  18. Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies
    Yukinori Hirano, Kunio Ihara, Tomoko Masuda, Takuya Yamamoto, Ikuko Iwata, Aya Takahashi, Hiroko Awata, Naosuke Nakamura, Mai Takakura, Yusuke Suzuki, Junjiro Horiuchi, Hiroyuki Okuno, Minoru Saitoe
    Nat Commun. (2016); 7:13471.
    DOI：https://doi.org/10.1038/ncomms13471
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/27841260
  19. Learning defects in Drosophila growth restricted chico mutants are caused by attenuated adenylyl cyclase activity
    Shintaro Naganos, Kohei Ueno, Junjiro Horiuchi, Minoru Saitoe
    Mol Brain. (2016); 9:37.
    DOI：https://doi.org/10.1186/s13041-016-0217-3
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/27048332
  20. Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43
    Takashi Nonaka, Genjiro Suzuki, Yoshinori Tanaka, Fuyuki Kametani, Shinobu Hirai, Haruo Okado, Tomoyuki Miyashita, Minoru Saitoe, Haruhiko Akiyama, Hisao Masai, Masato Hasegawa
    J Biol Chem. (2016); 291(11):5473-5483.
    DOI：https://doi.org/10.1074/jbc.M115.695379
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/26769969
  21. Long-term memory formation in Drosophila requires training-dependent glial transcription
    Motomi Matsuno, Junjiro Horiuchi, Yoshihiro Yuasa, Kyoko Ofusa, Tomoyuki Miyashita, Tomoko Masuda, Minoru Saitoe
    J Neurosci. (2015); 35(14):5557-65.
    DOI：https://doi.org/10.1523/JNEUROSCI.3865-14.2015
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/25855172
  22. Glial dysfunction causes age-related memory impairment in Drosophila
    Daisuke Yamazaki, Junjiro Horiuchi, Kohei Ueno, Taro Ueno, Shinjiro Saeki, Motomi Matsuno, Shintaro Naganos, Tomoyuki Miyashita, Yukinori Hirano, Hiroyuki Nishikawa, Masato Taoka, Yoshio Yamauchi, Toshiaki Isobe, Yoshiko Honda, Tohru Kodama, Tomoko Masuda, Minoru Saitoe
    Neuron. (2014); 84(4):753-63.
    DOI：https://doi.org/10.1016/j.neuron.2014.09.039
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/25447741
  23. [ Hunger-driven modulation in brain functions ]
    Yukinori Hirano, Minoru Saitoe
    Brain Nerve. (2014); 66(1):41-8.
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/24371130
  24. Hunger and memory; CRTC coordinates long-term memory with the physiological state, hunger
    Yukinori Hirano, Minoru Saitoe
    Commun Integr Biol. (2013); 6(5):e25152.
    DOI：https://doi.org/10.4161/cib.25152
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/24265850
  25. Fasting launches CRTC to facilitate long-term memory formation in Drosophila.
    Yukinori Hirano, Tomoko Masuda, Shintaro Naganos, Motomi Matsuno, Kohei Ueno, Tomoyuki Miyashita, Junjiro Horiuchi, Minoru Saitoe
    Science. (2013); 339(6118):443-6.
    DOI：https://doi.org/10.1126/science.1227170
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/23349290
  26. Age-related memory impairment in Drosophila
    Minoru Saitoe, Shinjiro Saeki, Yukinori Hirano, Junjiro Horiuchi
    Behavioral Genetics of the Fly (Drosophila Melanogaster). (2013); 177-182
    DOI：https://doi.org/10.1017/CBO9780511920585.014
  27. Long-term enhancement of synaptic transmission between antennal lobe and mushroom body in cultured Drosophila brain
    Kohei Ueno, Shintaro Naganos, Yukinori Hirano, Junjiro Horiuchi, Minoru Saitoe
    J Physiol. (2013); 591(1):287-302.
    DOI：https://doi.org/10.1113/jphysiol.2012.242909
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/23027817
  28. Perlecan regulates bidirectional Wnt signaling at the Drosophila neuromuscular junction
    Keisuke Kamimura, Kohei Ueno, Jun Nakagawa, Rie Hamada, Minoru Saitoe, Nobuaki Maeda
    J Cell Biol. (2013); 200(2):219-33.
    DOI：https://doi.org/10.1083/jcb.201207036
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/23319599
  29. Mg(2+) block of Drosophila NMDA receptors is required for long-term memory formation and CREB-dependent gene expression
    Tomoyuki Miyashita, Yoshiaki Oda, Junjiro Horiuchi, Jerry C. P. Yin, Takako Morimoto, Minoru Saitoe
    Neuron. (2012); 74(5):887-98.
    DOI：https://doi.org/10.1016/j.neuron.2012.03.039
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/22681692
  30. Mutations in the Drosophila insulin receptor substrate, CHICO, impair olfactory associative learning
    Shintaro Naganos, Junjiro Horiuchi, Minoru Saitoe
    Neurosci Res. (2012); 73(1):49-55.
    DOI：https://doi.org/10.1016/j.neures.2012.02.001
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/22342328
  31. Reactive oxygen species are not involved in the onset of age-related memory impairment in Drosophila
    Y. Hirano, Y. Kuriyama, T. Miyashita, J. Horiuchi, M. Saitoe
    Genes Brain Behav. (2012); 11(1):79-86.
    DOI：https://doi.org/10.1111/j.1601-183X.2011.00748.x
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/22107594
  32. Acute inhibition of PKA activity at old ages ameliorates age-related memory impairment in Drosophila
    Daisuke Yamazaki, Junjiro Horiuchi, Tomoyuki Miyashita, Minoru Saitoe
    J Neurosci. (2010); 30(46):15573-7.
    DOI：https://doi.org/10.1523/JNEUROSCI.3229-10.2010
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/21084612
  33. Drosophila PQBP1 regulates learning acquisition at projection neurons in aversive olfactory conditioning
    Takuya Tamura, Daisuke Horiuchi, Yi-Chung Chen, Masaki Sone, Tomoyuki Miyashita, Minoru Saitoe, Natsue Yoshimura, Ann-Shyn Chiang, Hitoshi Okazawa
    J Neurosci. (2010); 30(42):14091-101.
    DOI：https://doi.org/10.1523/JNEUROSCI.1319-10.2010
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/20962230
  34. The Drosophila cell adhesion molecule Klingon is required for long-term memory formation and is regulated by Notch
    Motomi Matsuno, Junjiro Horiuchi, Tim Tully, Minoru Saitoe
    Proc Natl Acad Sci U S A. (2009); 106(1):310-5.
    DOI：https://doi.org/10.1073/pnas.0807665106
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/19104051
  35. Protein kinase A inhibits a consolidated form of memory in Drosophila
    Junjiro Horiuchi, Daisuke Yamazaki, Shintaro Naganos, Toshiro Aigaki, Minoru Saitoe
    Proc Natl Acad Sci U S A. (2008); 105(52):20976-81.
    DOI：https://doi.org/10.1073/pnas.0810119105
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/19075226
  36. [ cAMP/PKA signaling underlies age-related memory impairment ]
    Daisuke Yamazaki, Minoru Saitoe
    Brain Nerve. (2008); 60(7):717-24.
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/18646611
  37. Modeling cognitive and neurodegenerative disorders in Drosophila melanogaster
    Junjiro Horiuchi, Minoru Saitoe
    Source Book of Models for Biomedical Research. (2008); 121-128
    DOI：https://doi.org/10.1007/978-1-59745-285-4_15
  38. The Drosophila DC0 mutation suppresses age-related memory impairment without affecting lifespan
    Daisuke Yamazaki, Junjiro Horiuchi, Yasuko Nakagami, Shintaro Nagano, Takuya Tamura, Minoru Saitoe
    Nat Neurosci. (2007); 10(4):478-84.
    DOI：https://doi.org/10.1038/nn1863
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/17322874
  39. Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases
    Mei-Ling Qi, Kazuhiko Tagawa, Yasushi Enokido, Natsue Yoshimura, Yo-ichi Wada, Kei Watase, Sho-ichi Ishiura, Ichiro Kanazawa, Juan Botas, Minoru Saitoe, Erich E Wanker, Hitoshi Okazawa
    Nat Cell Biol. (2007); 9(4):402-14.
    DOI：https://doi.org/10.1038/ncb1553
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/17384639
  40. Expression of human PQBP-1 in Drosophila impairs long-term memory and induces abnormal courtship
    Natsue Yoshimura, Daisuke Horiuchi, Masao Shibata, Minoru Saitoe, Mei-Ling Qi, Hitoshi Okazawa
    FEBS Lett. (2006); 580(9):2335-40.
    DOI：https://doi.org/10.1016/j.febslet.2006.03.056
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/16597440
  41. Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73
    Masataka Hoshino, Mei-ling Qi, Natsue Yoshimura, Tomoyuki Miyashita, Kazuhiko Tagawa, Yo-ichi Wada, Yasushi Enokido, Shigeki Marubuchi, Phoebe Harjes, Nobutaka Arai, Kiyomitsu Oyanagi, Giovanni Blandino, Marius Sudol, Tina Rich, Ichiro Kanazawa, Erich E Wanker, Minoru Saitoe, Hitoshi Okazawa
    J Cell Biol. (2006); 172(4):589-604.
    DOI：https://doi.org/10.1083/jcb.200509132
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/16461361
  42. NMDA receptors mediate olfactory learning and memory in Drosophila
    Shouzhen Xia, Tomoyuki Miyashita, Tsai-Feng Fu, Wei-Yong Lin, Chia-Lin Wu, Lori Pyzocha, Inn-Ray Lin, Minoru Saitoe, Tim Tully, Ann-Shyn Chiang
    Curr Biol. (2005); 15(7):603-15.
    DOI：https://doi.org/10.1016/j.cub.2005.02.059
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/15823532
  43. Can flies shed light on our own age-related memory impairment?
    Junjiro Horiuchi, Minoru Saitoe
    Ageing Res Rev. (2005); 4(1):83-101.
    DOI：https://doi.org/10.1016/j.arr.2004.10.001
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/15619472
  44. Drosophila as a novel animal model for studying the genetics of age-related memory impairment
    Minoru Saitoe, Junjiro Horiuchi, Takuya Tamura, Naomi Ito
    Rev Neurosci. (2005); 16(2):137-49.
    DOI：https://doi.org/10.1515/revneuro.2005.16.2.137
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/15957577
  45. 記憶遺伝子amnesiacと寿命遺伝子methuselahの相互作用によるの記憶と寿命の制御(Interaction of the memory gene amnesiac and the aging gene methuselah in longevity and memory)
    齊藤 実, 堀内 純二郎, 宮下 知之, 伊東 直美
    神経化学. (2004); 43(2-3) 509-509.
  46. [ Identification of the memory component that decays with age in Drosophila ]
    Minoru Saitoe, Takuya Tamura, Junjiro Horiuchi, Naomi Ito
    Nihon Shinkei Seishin Yakurigaku Zasshi. (2004); 24(4):231-7.
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/15484825
  47. Aging specifically impairs amnesiac-dependent memory in Drosophila
    Takuya Tamura, Ann-Shyn Chiang, Naomi Ito, Hsin-Ping Liu, Junjiro Horiuchi, Tim Tully, Minoru Saitoe
    Neuron. (2003); 40(5):1003-11.
    DOI：https://doi.org/10.1016/S0896-6273(03)00732-3
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/14659098
  48. Response: meaningless minis?
    Minoru Saitoe, Thomas L Schwarz, Joy A Umbach, Cameron B Gundersen, Yoshi Kidokoro
    Trends Neurosci. (2002); 25(8):385-6.
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/12127746
  49. Absence of junctional glutamate receptor clusters in Drosophila mutants lacking spontaneous transmitter release
    M. Saitoe, T. L. Schwarz, J. A. Umbach, C. B. Gundersen, Y. Kidokoro
    Science. (2001); 293(5529):514-7.
    DOI：https://doi.org/10.1126/science.1061270
    PubMed：https://www.ncbi.nlm.nih.gov/pubmed/11463917

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