Kamiyama Y, Sunada T, Fukui T, Hikami K, Mizuno K, Goto T, Ogawa O, Kobayashi T, Sasanuma H, Akamatsu S. Dual inhibition of PARP and ATR induces homologous recombination repair deficiency and leads to synthetic lethality in prostate cancer with CDK12 aberration
2026 in press Molecular Cancer Therapies.
Hirai H, Ohta K. TORC2 inactivation promotes heterochromatin formation in rDNA and prolongs viability of quiescent fission yeast cells Commun Biol. 2025 Nov 19;8(1):1606.
doi：10.1038/s42003-025-08953-5
Celik C, Kakusho N, Xu T, Lee SS, Yoshizawa-Sugata N, Masai H, Yamakoshi Y. Water-soluble cationic porphyrins with enhanced phototoxicity to cancer cell lines for G4-targeting photodynamic therapy RSC Med Chem. 2025 Oct 1.
doi：10.1039/d5md00706b
Tanaka T, Seki Y, Masai H. dif-XerCD is required for chromosome segregation during cSDR-dependent growth in E. coli bioRxiv. 2025 Sep 02.673814.
doi：10.1101/2025.09.02.673814
Yang CC, Goto H, Oyadomari S, Masai H. Phosphorylation of Claspin by elF2α kinase protects cells from heat stress bioRxiv. 2025 Aug 21.670878.
doi：10.1101/2025.08.21.670878
Tanegashima K, Esashi E, Ishida K, Kotaki A, Iwase R, Hasebe M, Takahashi R, Saito R, Kazuki Y, Suzuki T, Hara T. CXCL14 is an essential modulator of TLR9 agonist-induced antitumor immune responses J Immunol. 2025 Aug 1;214(8):2076-2086.
doi：10.1093/jimmun/vkaf080
Sakuraba H, Tsukimura T, Shiga T, Saito S, Tajima Y, Kawashima I, Fukushige T, Togawa T. Enzyme replacement therapy using a modified α-N-acetylgalactosaminidase to suppress progressive glycolipid accumulation and escape from antidrug antibody formation in young human NAGA-transgenic/Gla-knockout mice Mol Genet Metab. 2025 Aug;145(4):109151.
doi：10.1016/j.ymgme.2025.109151
Tanaya Y, Sashida M, Masai H, Sasanuma H, Miura D, Asano R, Nagasawa K, Tera M. Evaluation of the effects of G4 ligands on the interaction between G-quadruplexes and their binding proteins Chem Commun (Camb). 2025 Jul 31;61(63):11790-11793.
doi：10.1039/d5cc02801a
Saito R, Hasebe M, Hara T, Tanegashima K. Expression cloning of cell surface receptors for the CpG oligodeoxynucleotide/CXCL14 complex Biochem Biophys Res Commun. 2025 Jul 1;768:151954.
doi：10.1016/j.bbrc.2025.151954
Yone H, Kawashima Y, Hirai H, Oda AH, Sato M, Kono H, Ohta K. Light-controlled Spo11-less meiotic DNA breaks by MagTAQing lead to chromosomal aberrations Nucleic Acids Res. 2025 Apr 10;53(7):gkaf206.
doi：10.1093/nar/gkaf206
Ogawa A, Izumikawa K, Tate S, Isoyama S, Mori M, Fujiwara K, Watanabe S, Ohga T, Jo U, Taniyama D, Kitajima S, Tanaka S, Onji H, Kageyama SI, Yamamoto G, Saito H, Morita TY, Okada M, Natsumeda M, Nagahama M, Kobayashi J, Ohashi A, Sasanuma H, Higashiyama S, Dan S, Pommier Y, Murai J. SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis Mol Cell. 2025 Mar 6;85(5):894-912.e10.
doi：10.1016/j.molcel.2025.01.008
Fracassi A, Qiao H, Lowell AN, Cao J, Bode JW, Masai H, Yoshizawa-Sugata N, Zhou R, Yamakoshi Y. Natural and Synthetic LDL-Based Imaging Probes for the Detection of Atherosclerotic Plaques ACS Pharmacol Transl Sci. 2025 Feb 4;8(2):578-591.
doi：10.1021/acsptsci.4c00667
Biller M, Kabir S, Nipper S, Allen S, Kayali Y, Kuncik S, Sasanuma H, Zhou P, Vaziri C, Tomida J. REV7 associates with ATRIP and inhibits ATR kinase activity bioRxiv. [Preprint]. 2025 Jan 18:2025.01.17.633588.
doi：10.1101/2025.01.17.633588
2024
Yamazaki K, Iguchi T, Kanoh Y, Takayasu K, Ngo TTT, Onuki A, Kawaji H, Oshima S, Kanda T, Masai H, Sasanuma H. Homologous recombination contributes to the repair of acetaldehyde-induced DNA damage Cell Cycle. 2024 Feb;23(4):369-384.
doi：10.1080/15384101.2024.2335028
Biller M, Kabir S, Boado C, Nipper S, Saffa A, Tal A, Allen S, Sasanuma H, Dréau D, Vaziri C, Tomida J. REV7-p53 interaction inhibits ATM-mediated DNA damage signaling Cell Cycle. 2024 Feb;23(4):339-352.
doi：10.1080/15384101.2024.2333227
Shibata T, Ikawa S, Iwasaki W, Sasanuma H, Masai H, Hirota K. Homology recognition without double-stranded DNA-strand separation in D-loop formation by RecA Nucleic Acids Res. 2024 Mar 21;52(5):2565-2577.
doi：10.1093/nar/gkad1260
Charlton SJ, Flury V, Kanoh Y, Genzor AV, Kollenstart L, Ao W, Brøgger P, Weisser MB, Adamus M, Alcaraz N, Delvaux de Fenffe CM, Mattiroli F, Montoya G, Masai H, Groth A, Thon G. The fork protection complex promotes parental histone recycling and epigenetic memory Cell. 2024 Sep 5;187(18):5029-5047.e21.
doi：10.1016/j.cell.2024.07.017
You Z, Masai H. Assembly, Activation, and Helicase Actions of MCM2-7: Transition from Inactive MCM2-7 Double Hexamers to Active Replication Forks Biology (Basel). 2024 Aug 17;13(8):629.
doi：10.3390/biology13080629
Tajima Y, Shibasaki F, Masai H. Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance Cancer Gene Ther. 2024 Jan;31(1):158-173.
doi：10.1038/s41417-023-00693-0
Kim S, Yamada S, Li T, Canasto-Chibuque C, Kim JH, Marcet-Ortega M, Xu J, Eng DY, Feeney L, Petrini JHJ, Keeney S. The MRE11-RAD50-NBS1 complex both starts and extends DNA end resection in mouse bioRxiv. 2024 Aug 17:2024.08.17.608390.
doi：10.1101/2024.08.17.608390
Kim S, Yamada S, Maekawa K, Keeney S. Optimized methods for mapping DNA double-strand-break ends and resection tracts and application to meiotic recombination in mouse spermatocytes bioRxiv, 2024 Aug 16.
doi：10.1101/2024.08.10.606181
2023
Tomita A, Sasanuma H, Owa T, Nakazawa Y, Shimada M, Fukuoka T, Ogi T, Nakada S. Inducing multiple nicks promotes interhomolog homologous recombination to correct heterozygous mutations in somatic cells Nat Commun. 2023 Sep 15;14(1):5607.
doi：10.1038/s41467-023-41048-5
Sakurada-Aono M, Sakamoto T, Kobayashi M, Takiuchi Y, Iwai F, Tada K, Sasanuma H, Hirabayashi S, Murakawa Y, Shirakawa K, Sakamoto C, Shindo K, Yasunaga JI, Matsuoka M, Pommier Y, Takeda S, Takaori-Kondo A. HTLV-1 bZIP factor impairs DNA mismatch repair system Biochem Biophys Res Commun. 2023 May 21;657:43-49.
doi：10.1016/j.bbrc.2023.03.049
Najnin RA, Al Mahmud MR, Rahman MM, Takeda S, Sasanuma H, Tanaka H, Murakawa Y, Shimizu N, Akter S, Takagi M, Sunada T, Akamatsu S, He G, Itou J, Toi M, Miyaji M, Tsutsui KM, Keeney S, Yamada S. ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen Cell Rep. 2023 Jan 31;42(1):111909.
doi：10.1016/j.celrep.2022.111909
Akter S, Shimba A, Ikuta K, Mahmud MRA, Yamada S, Sasanuma H, Tsuda M, Sone M, Ago Y, Murai K, Tanaka H, Takeda S. Physiological concentrations of glucocorticoids induce pathological DNA double-strand breaks Genes Cells. 2023 Jan;28(1):53-67.
doi：10.1111/gtc.12993
Sun W, Lee KL, Poellinger L, Masai H, Kato H. Catalytic domain-dependent and -independent transcriptional activities of the tumour suppressor histone H3K27 demethylase UTX/KDM6A in specific cancer types Epigenetics. 2023 Dec;18(1):2222245.
doi：10.1080/15592294.2023.2222245
Hori K, Yamazaki S, Ohtaka-Maruyama C, Ono T, Iguchi T, Masai H. Cdc7 kinase is required for postnatal brain development Genes Cells. 2023 Oct;28(10):679-693.
doi：10.1111/gtc.13059
Hsiao HW, Yang CC, Masai H. Correction: Hsiao et al. Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses. Biomolecules 2023, 13, 125 Biomolecules. 2023 Jul 18;13(7):1145.
doi：10.3390/biom13071145
Nemeth T, Yoshizawa-Sugata N, Pallier A, Tajima Y, Ma Y, Tóth É, Masai H, Yamakoshi Y. Water-Soluble Gd(III)-Porphyrin Complexes Capable of Both Photosensitization and Relaxation Enhancement Chem Biomed Imaging. 2023 May 12;1(2):157-167.
doi：10.1021/cbmi.3c00007
Kanoh Y, Ueno M, Hayano M, Kudo S, Masai H. Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect Life Sci Alliance. 2023 Feb 7;6(4):e202201603.
doi：10.26508/lsa.202201603
Hsiao HW, Yang CC, Masai H. Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses Biomolecules. 2023 Jan 7;13(1):125.
doi：10.3390/biom13010125
Yang CC, Masai H. Claspin is Required for Growth Recovery from Serum Starvation through Regulating the PI3K-PDK1-mTOR Pathway in Mammalian Cells Mol Cell Biol. 2023 Jan;43(1):1-21.
doi：10.1080/10985549.2022.2160598
Yoshizawa-Sugata N, Masai H. Histone Modification Analysis of Low-Mappability Regions Methods Mol Biol. 2023;2519:163-185.
doi：10.1007/978-1-0716-2433-3_18
2022
Nakano T, Moriwaki T, Tsuda M, Miyakawa M, Hanaichi Y, Sasanuma H, Hirota K, Kawanishi M, Ide H, Tano K, Bessho T. SPRTN and TDP1/TDP2 Independently Suppress 5-Aza-2'-deoxycytidine-Induced Genomic Instability in Human TK6 Cell Line Chem Res Toxicol. 2022 Nov 21;35(11):2059-2067.
doi：10.1021/acs.chemrestox.2c00213
Hirota K, Ooka M, Shimizu N, Yamada K, Tsuda M, Ibrahim MA, Yamada S, Sasanuma H, Masutani M, Takeda S. XRCC1 counteracts poly(ADP ribose)polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal of trapped PARP1 from broken DNA Genes Cells. 2022 May;27(5):331-344.
doi：10.1111/gtc.12929
Masai H. Replicon hypothesis revisited Biochem Biophys Res Commun. 2022 Dec 10;633:77-80.
doi：10.1016/j.bbrc.2022.09.060
Masai H. TT-pocket/HIRAN: binding to 3'-terminus of DNA for recognition and processing of stalled replication forks J Biochem. 2022 Jul 25;172(2):57-60.
doi：10.1093/jb/mvac042
Nakamura H, Sekine H, Kato H, Masai H, Gradin K, Poellinger L. Hypoxia-inducible factor-1α and poly [ADP ribose] polymerase 1 cooperatively regulate Notch3 expression under hypoxia via a noncanonical mechanism J Biol Chem. 2022 Jul;298(7):102137.
doi：10.1016/j.jbc.2022.102137
2021
Moriwaki T, Yoshimura A, Tamari Y, Sasanuma H, Takeda S, Seki M, Tano K. PRDX1 is essential for the viability and maintenance of reactive oxygen species in chicken DT40 Genes Environ. 2021 Aug 5;43(1):35.
doi：10.1186/s41021-021-00211-4
Isobe SY, Hiraga SI, Nagao K, Sasanuma H, Donaldson AD, Obuse C. Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action Cell Rep. 2021 Jul 13;36(2):109383.
doi：10.1016/j.celrep.2021.109383
Kratz K, Artola-Borán M, Kobayashi-Era S, Koh G, Oliveira G, Kobayashi S, Oliveira A, Zou X, Richter J, Tsuda M, Sasanuma H, Takeda S, Loizou JI, Sartori AA, Nik-Zainal S, Jiricny J. FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair Mol Cell Biol. 2021 Aug 24;41(9):e0030321.
doi：10.1128/MCB.00303-21
Xu X, Xu Y, Guo R, Xu R, Fu C, Xing M, Sasanuma H, Li Q, Takata M, Takeda S, Guo R, Xu D. Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress Nat Struct Mol Biol. 2021 Jun;28(6):487-500.
doi：10.1038/s41594-021-00602-9
Demin AA, Hirota K, Tsuda M, Adamowicz M, Hailstone R, Brazina J, Gittens W, Kalasova I, Shao Z, Zha S, Sasanuma H, Hanzlikova H, Takeda S, Caldecott KW. XRCC1 prevents toxic PARP1 trapping during DNA base excision repair Mol Cell. 2021 Jul 15;81(14):3018-3030.e5.
doi：10.1016/j.molcel.2021.05.009
Moribe F, Nishikori M, Takashima T, Taniyama D, Onishi N, Arima H, Sasanuma H, Akagawa R, Elloumi F, Takeda S, Pommier Y, Morii E, Takaori-Kondo A, Murai J. Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development PLoS One. 2021 Jan 29;16(1):e0237554.
doi：10.1371/journal.pone.0237554
Yoshizawa-Sugata N, Yamazaki S, Mita-Yoshida K, Ono T, Nishito Y, Masai H. Loss of full-length DNA replication regulator Rif1 in two-cell embryos is associated with zygotic transcriptional activation J Biol Chem. 2021 Dec;297(6):101367.
doi：10.1016/j.jbc.2021.101367
Irie T, Asami T, Sawa A, Uno Y, Taniyama C, Funakoshi Y, Masai H, Sawa M. Discovery of AS-0141, a Potent and Selective Inhibitor of CDC7 Kinase for the Treatment of Solid Cancers J Med Chem. 2021 Oct 14;64(19):14153-14164.
doi：10.1021/acs.jmedchem.1c01319
Oki M, Masai H. Regulation of HP1 protein by phosphorylation during transcriptional repression and cell cycle J Biochem. 2021 Sep 7;169(6):629-632.
doi：10.1093/jb/mvab040
Nakamura K, Sakai S, Tsuyama J, Nakamura A, Otani K, Kurabayashi K, Yogiashi Y, Masai H, Shichita T. Extracellular DJ-1 induces sterile inflammation in the ischemic brain PLoS Biol. 2021 May 20;19(5):e3000939.
doi：10.1371/journal.pbio.3000939
Kitajima S, Sun W, Lee KL, Ho JC, Oyadomari S, Okamoto T, Masai H, Poellinger L, Kato H. A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition Sci Rep. 2021 Feb 25;11(1):4538.
doi：10.1038/s41598-021-83857-y
Alavi S, Ghadiri H, Dabirmanesh B, Moriyama K, Khajeh K, Masai H. G-quadruplex binding protein Rif1, a key regulator of replication timing J Biochem. 2021 Feb 6;169(1):1-14.
doi：10.1093/jb/mvaa128
2020
Rahman MM, Mohiuddin M, Shamima Keka I, Yamada K, Tsuda M, Sasanuma H, Andreani J, Guerois R, Borde V, Charbonnier JB, Takeda S. Genetic evidence for the involvement of mismatch repair proteins, PMS2 and MLH3, in a late step of homologous recombination J Biol Chem. 2020 Dec 18;295(51):17460-17475.
doi：10.1074/jbc.RA120.013521
Takeishi A, Kogashi H, Odagiri M, Sasanuma H, Takeda S, Yasui M, Honma M, Suzuki T, Kamiya H, Sugasawa K, Ura K, Sassa A. Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells PLoS One. 2020 Dec 31;15(12):e0244790.
doi：10.1371/journal.pone.0244790
Sasanuma H, Yamada S, Tsuda M, Takeda S. Restoration of ligatable "clean" double-strand break ends is the rate-limiting step in the rejoining of ionizing-radiation-induced DNA breakage DNA Repair (Amst). 2020 Sep;93:102913.
doi：10.1016/j.dnarep.2020.102913
Nakano T, Shoulkamy MI, Tsuda M, Sasanuma H, Hirota K, Takata M, Masunaga SI, Takeda S, Ide H, Bessho T, Tano K. Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells PLoS One. 2020 Jun 26;15(6):e0234859.
doi：10.1371/journal.pone.0234859
Saha LK, Wakasugi M, Akter S, Prasad R, Wilson SH, Shimizu N, Sasanuma H, Huang SN, Agama K, Pommier Y, Matsunaga T, Hirota K, Iwai S, Nakazawa Y, Ogi T, Takeda S. Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14412-14420.
doi：10.1073/pnas.1920165117
Akagawa R, Trinh HT, Saha LK, Tsuda M, Hirota K, Yamada S, Shibata A, Kanemaki MT, Nakada S, Takeda S, Sasanuma H. UBC13-Mediated Ubiquitin Signaling Promotes Removal of Blocking Adducts from DNA Double-Strand Breaks iScience. 2020 Apr 24;23(4):101027.
doi：10.1016/j.isci.2020.101027
Al Mahmud MR, Ishii K, Bernal-Lozano C, Delgado-Sainz I, Toi M, Akamatsu S, Fukumoto M, Watanabe M, Takeda S, Cortés-Ledesma F, Sasanuma H. TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands Genes Cells. 2020 Jul;25(7):450-465.
doi：10.1111/gtc.12770
Ibrahim MA, Yasui M, Saha LK, Sasanuma H, Honma M, Takeda S. Enhancing the sensitivity of the thymidine kinase assay by using DNA repair-deficient human TK6 cells Environ Mol Mutagen. 2020 Jul;61(6):602-610.
doi：doi: 10.1002/em.22371
Itou J, Takahashi R, Sasanuma H, Tsuda M, Morimoto S, Matsumoto Y, Ishii T, Sato F, Takeda S, Toi M. Estrogen Induces Mammary Ductal Dysplasia via the Upregulation of Myc Expression in a DNA-Repair-Deficient Condition iScience. 2020 Feb 21;23(2):100821.
doi：10.1016/j.isci.2020.100821
Maekawa K, Yamada S, Sharma R, Chaudhuri J, Keeney S. Triple-helix potential of the mouse genome Proc Natl Acad Sci U S A, 2022 May 03.
doi：10.1073/pnas.2203967119
Yamada S, Hinch AG, Kamido H, Zhang Y, Edelmann W, Keeney S. Molecular structures and mechanisms of DNA break processing in mouse meiosis Genes Dev, 2020 May 02.
doi：10.1101/gad.336032.119
2019
Morimoto S, Tsuda M, Bunch H, Sasanuma H, Austin C, Takeda S. Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA Genes (Basel). 2019 Oct 30;10(11):868.
doi：10.3390/genes10110868
Sassa A, Tada H, Takeishi A, Harada K, Suzuki M, Tsuda M, Sasanuma H, Takeda S, Sugasawa K, Yasui M, Honma M, Ura K. Processing of a single ribonucleotide embedded into DNA by human nucleotide excision repair and DNA polymerase η Sci Rep. 2019 Sep 26;9(1):13910.
doi：10.1038/s41598-019-50421-8
Gothe HJ, Bouwman BAM, Gusmao EG, Piccinno R, Petrosino G, Sayols S, Drechsel O, Minneker V, Josipovic N, Mizi A, Nielsen CF, Wagner EM, Takeda S, Sasanuma H, Hudson DF, Kindler T, Baranello L, Papantonis A, Crosetto N, Roukos V. Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations Mol Cell. 2019 Jul 25;75(2):267-283.e12.
doi：10.1016/j.molcel.2019.05.015
Sasanuma H, Sakurai HSM, Furihata Y, Challa K, Palmer L, Gasser SM, Shinohara M, Shinohara A. Srs2 helicase prevents the formation of toxic DNA damage during late prophase I of yeast meiosis Chromosoma. 2019 Sep;128(3):453-471.
doi：10.1007/s00412-019-00709-5
Tsuda M, Ogawa S, Ooka M, Kobayashi K, Hirota K, Wakasugi M, Matsunaga T, Sakuma T, Yamamoto T, Chikuma S, Sasanuma H, Debatisse M, Doherty AJ, Fuchs RP, Takeda S. PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching PLoS One. 2019 Mar 6;14(3):e0213383.
doi：10.1371/journal.pone.0213383
Zong D, Adam S, Wang Y, Sasanuma H, Callén E, Murga M, Day A, Kruhlak MJ, Wong N, Munro M, Ray Chaudhuri A, Karim B, Xia B, Takeda S, Johnson N, Durocher D, Nussenzweig A. BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation Mol Cell. 2019 Mar 21;73(6):1267-1281.e7.
doi：10.1016/j.molcel.2018.12.010
2018
Mohiuddin M, Evans TJ, Rahman MM, Keka IS, Tsuda M, Sasanuma H, Takeda S. SUMOylation of PCNA by PIAS1 and PIAS4 promotes template switch in the chicken and human B cell lines Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12793-12798.
doi：10.1073/pnas.1716349115
Sasanuma H, Tsuda M, Morimoto S, Saha LK, Rahman MM, Kiyooka Y, Fujiike H, Cherniack AD, Itou J, Callen Moreu E, Toi M, Nakada S, Tanaka H, Tsutsui K, Yamada S, Nussenzweig A, Takeda S. BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10642-E10651.
doi：10.1073/pnas.1803177115
Saha LK, Kim S, Kang H, Akter S, Choi K, Sakuma T, Yamamoto T, Sasanuma H, Hirota K, Nakamura J, Honma M, Takeda S, Dertinger S. Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms Environ Mol Mutagen. 2018 Jul;59(6):529-538.
doi：10.1002/em.22201
Sanada Y, Sasanuma H, Takeda S, Tano K, Masunaga SI. Disruption of Hif-1α enhances cytotoxic effects of metformin in murine squamous cell carcinoma Int J Radiat Biol. 2018 Jan;94(1):88-96.
doi：10.1080/09553002.2018.1409443
2017
Çaglayan M, Prasad R, Krasich R, Longley MJ, Kadoda K, Tsuda M, Sasanuma H, Takeda S, Tano K, Copeland WC, Wilson SH. Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts Nucleic Acids Res. 2017 Sep 29;45(17):10079-10088.
doi：10.1093/nar/gkx654
Kadoda K, Moriwaki T, Tsuda M, Sasanuma H, Ishiai M, Takata M, Ide H, Masunaga SI, Takeda S, Tano K. Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells PLoS One. 2017 Sep 19;12(9):e0185141.
doi：10.1371/journal.pone.0185141
Al Abo M, Sasanuma H, Liu X, Rajapakse VN, Huang SY, Kiselev E, Takeda S, Plunkett W, Pommier Y. TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors Mol Cancer Ther. 2017 Nov;16(11):2543-2551.
doi：10.1158/1535-7163.MCT-17-0110
Tsuda M, Terada K, Ooka M, Kobayashi K, Sasanuma H, Fujisawa R, Tsurimoto T, Yamamoto J, Iwai S, Kadoda K, Akagawa R, Huang SN, Pommier Y, Sale JE, Takeda S, Hirota K. The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C) Oncotarget. 2017 May 16;8(20):33457-33474.
doi：10.18632/oncotarget.16508
Moriwaki T, Okamoto S, Sasanuma H, Nagasawa H, Takeda S, Masunaga SI, Tano K. Cytotoxicity of Tirapazamine (3-Amino-1,2,4-benzotriazine-1,4-dioxide)-Induced DNA Damage in Chicken DT40 Cells Chem Res Toxicol. 2017 Feb 20;30(2):699-704.
doi：10.1021/acs.chemrestox.6b00417
Yamada S, Kim S, Tischfield SE, Jasin M, Lange J, Keeney S. Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice Cell Cycle. 2017 Aug 19.
doi：10.1080/15384101.2017.1361065
Mimitou EP, Yamada S, Keeney S. A global view of meiotic double-strand break end resection Science. 2017 Jan 07.
doi：10.1126/science.aak9704
2016
Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H. Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes Mol Cell. 2016 Dec 1;64(5):1010.
doi：10.1016/j.molcel.2016.11.028
Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H. Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes Mol Cell. 2016 Nov 3;64(3):580-592.
doi：10.1016/j.molcel.2016.10.011
Hashimoto K, Sharma V, Sasanuma H, Tian X, Takata M, Takeda S, Swenberg JA, Nakamura J. Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells Oncotarget. 2016 Sep 13;7(37):59795-59808.
doi：10.18632/oncotarget.10928
Takeda S, Hoa NN, Sasanuma H. The role of the Mre11-Rad50-Nbs1 complex in double-strand break repair-facts and myths J Radiat Res. 2016 Aug;57 Suppl 1(Suppl 1):i25-i32.
doi：10.1093/jrr/rrw034
Marchand C, Abdelmalak M, Kankanala J, Huang SY, Kiselev E, Fesen K, Kurahashi K, Sasanuma H, Takeda S, Aihara H, Wang Z, Pommier Y. Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2 ACS Chem Biol. 2016 Jul 15;11(7):1925-33.
doi：10.1021/acschembio.5b01047
Mohiuddin, Kobayashi S, Keka IS, Guilbaud G, Sale J, Narita T, Abdel-Aziz HI, Wang X, Ogawa S, Sasanuma H, Chiu R, Oestergaard VH, Lisby M, Takeda S. The role of HERC2 and RNF8 ubiquitin E3 ligases in the promotion of translesion DNA synthesis in the chicken DT40 cell line DNA Repair (Amst). 2016 Apr;40:67-76.
doi：10.1016/j.dnarep.2016.02.002
Gothwal SK, Patel NJ, Colletti MM, Sasanuma H, Shinohara M, Hochwagen A, Shinohara A. The Double-Strand Break Landscape of Meiotic Chromosomes Is Shaped by the Paf1 Transcription Elongation Complex in Saccharomyces cerevisiae Genetics. 2016 Feb;202(2):497-512.
doi：10.1534/genetics.115.177287
Lange J, Yamada S, Tischfield SE, Pan J, Kim S, Zhu X, Socci ND, Jasin M, Keeney S. The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair Cell. 2016 Oct 18.
doi：10.1016/j.cell.2016.09.035
2015
Tada K, Kobayashi M, Takiuchi Y, Iwai F, Sakamoto T, Nagata K, Shinohara M, Io K, Shirakawa K, Hishizawa M, Shindo K, Kadowaki N, Hirota K, Yamamoto J, Iwai S, Sasanuma H, Takeda S, Takaori-Kondo A. Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia Sci Adv. 2015 Apr 24;1(3):e1400203.
doi：10.1126/sciadv.1400203
Hoa NN, Akagawa R, Yamasaki T, Hirota K, Sasa K, Natsume T, Kobayashi J, Sakuma T, Yamamoto T, Komatsu K, Kanemaki MT, Pommier Y, Takeda S, Sasanuma H. Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines Genes Cells. 2015 Dec;20(12):1059-76.
doi：10.1111/gtc.12310
Keka IS, Mohiuddin, Maede Y, Rahman MM, Sakuma T, Honma M, Yamamoto T, Takeda S, Sasanuma H. Smarcal1 promotes double-strand-break repair by nonhomologous end-joining Nucleic Acids Res. 2015 Jul 27;43(13):6359-72.
doi：10.1093/nar/gkv621
Hoa NN, Kobayashi J, Omura M, Hirakawa M, Yang SH, Komatsu K, Paull TT, Takeda S, Sasanuma H. BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination PLoS One. 2015 Apr 24;10(4):e0124495.
doi：10.1371/journal.pone.0124495
2014
Okamoto S, Narita T, Sasanuma H, Takeda S, Masunaga S, Bessho T, Tano K. Impact of DNA repair pathways on the cytotoxicity of piperlongumine in chicken DT40 cell-lines Genes Cancer. 2014 Jul;5(7-8):285-92.
doi：10.18632/genesandcancer.26
Hirota K, Tsuda M, Murai J, Takagi T, Keka IS, Narita T, Fujita M, Sasanuma H, Kobayashi J, Takeda S. SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss Genes Cells. 2014 Oct;19(10):743-54.
doi：10.1111/gtc.12173
2013
Sasanuma H, Furihata Y, Shinohara M, Shinohara A. Remodeling of the Rad51 DNA strand-exchange protein by the Srs2 helicase Genetics. 2013 Aug;194(4):859-72.
doi：10.1534/genetics.113.150615
Sasanuma H, Tawaramoto MS, Lao JP, Hosaka H, Sanda E, Suzuki M, Yamashita E, Hunter N, Shinohara M, Nakagawa A, Shinohara A. A new protein complex promoting the assembly of Rad51 filaments Nat Commun. 2013;4:1676.
doi：10.1038/ncomms2678
Fujita M, Sasanuma H, Yamamoto KN, Harada H, Kurosawa A, Adachi N, Omura M, Hiraoka M, Takeda S, Hirota K. Interference in DNA replication can cause mitotic chromosomal breakage unassociated with double-strand breaks PLoS One. 2013;8(4):e60043.
doi：10.1371/journal.pone.0060043
2009
Kugou K, Fukuda T, Yamada S, Ito M, Sasanuma H, Mori S, Katou Y, Itoh T, Matsumoto K, Shibata T, Shirahige K, Ohta K. Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes Mol Biol Cell. 2009 Jul;20(13):3064-76.
doi：10.1091/mbc.e08-12-1223
Sasanuma H, Ohta K. [Formation of DNA double-strand breaks in meiosis] Tanpakushitsu Kakusan Koso. 2009 Mar;54(4 Suppl):459-65.,2009
2008
Sasanuma H, Hirota K, Fukuda T, Kakusho N, Kugou K, Kawasaki Y, Shibata T, Masai H, Ohta K. Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination Genes Dev. 2008 Feb 1;22(3):398-410.
doi：10.1101/gad.1626608
2007
Fukuda T, Kugou K, Sasanuma H, Shibata T, Ohta K. Targeted induction of meiotic double-strand breaks reveals chromosomal domain-dependent regulation of Spo11 and interactions among potential sites of meiotic recombination Nucleic Acids Res. 2008 Feb;36(3):984-97.
doi：10.1093/nar/gkm1082
Kugou K, Sasanuma H, Matsumoto K, Shirahige K, Ohta K. Mre11 mediates gene regulation in yeast spore development Genes Genet Syst. 2007 Feb;82(1):21-33.
doi：10.1266/ggs.82.21
Sasanuma H, Murakami H, Fukuda T, Shibata T, Nicolas A, Ohta K. Meiotic association between Spo11 regulated by Rec102, Rec104 and Rec114 Nucleic Acids Res. 2007;35(4):1119-33.
doi：10.1093/nar/gkl1162
2003
Araki Y, Kawasaki Y, Sasanuma H, Tye BK, Sugino A. Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability Genes Cells. 2003 May;8(5):465-80.
doi：10.1046/j.1365-2443.2003.00648.x
