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Our Team

About Us

Genomic instability is a common characteristic of cancer. The causes of genomic instability include abnormalities in DNA replication and DNA damage repair. We are interested in understanding the mechanisms of DNA damage repair and the pathogenesis of diseases caused by its disruption.
f you are interested in our research, please contact us.

Project Leader

Hiroyuki Sasanuma

Project Leader

mail:sasanuma-hr

Hiroyuki’s research focuses on the molecular mechanisms involved in the repair of DNA double-strand breaks. He uses yeast, human cell lines, and mice as model organisms. He currently conducts experiments both at the bench and in the culture room, similar to a postdoctoral researcher. Hiroyuki is particularly interested in developing new therapies to cure cancer. His hobbies include reading books and listening to music. He also loves skiing and visits the Zao Ski Resort in Yamagata alone every year.

Senior Investigator

Hisao Masai

mail:masai-hs

See previous information here (in Japanese).

Research Scientist

Kenji Kitajima

Kosuke Tanegashima

Hayato Hirai

Shintaro Yamada

Shintaro Yamada wants to understand how cells repair DNA efficiently. Radiation and other naturally occurring exogenous and endogenous DNA damaging agents often generate genomic DNA breaks with chemically modified DNA ends that are highly carcinogenic. Cleaning the modified DNA ends is a critical step of DNA repair, but much remains unknown about its molecular mechanism. To understand this process, Yamada is developing high-resolution methods and examining how DNA repair machinery works at DNA break ends and prevents cancer-causing genetic mutations in human cells.

Yutaka Kanoh

Tomohiro Iguchi

Zhiying You

I am working on a research project analyzing the functions of the DNA replication helicase MCM and the replication fork stabilizer Claspin protein in the initiation and progression of DNA replication. My focus is on understanding how Claspin phosphorylation regulates the activity of the replication fork complex.
My hobbies include listening to music and traveling.

Taku Tanaka

Youichi Tajima

Takehiko Shibata

External Support Investigator

Sayuri Ito

Students

Ngô Thị Tố Trinh
NGO THI TO TRINH

(D4, Ochanomizu Univ.)

Trinh's research focuses on Topoisomerase proteins and their contribution to cancer, as well as their activities on the genome. She wants to explore the mysteries of this world through the eye of science, which is why she chose to become a scientist. Her hobbies vary based on her emotions.

Lanxin Zheng

(M2, The University of Tokyo)

I am interested in exploring the biology field to answer three questions: What will happen? How will it happen? And how will it influence our body? Beyond the lab, I enjoy hiking, playing badminton, and photography. These activities not only provide a well-rounded balance to rigorous research but also inspire innovative approaches in my scientific endeavors.

Kazuto Takayasu

(M1, Niigata Univ.)

I am studying factors involved in genome repair by preparing samples for next generation sequencing (NGS) and in silico analysis. My hobbies are building hand made PC and traveling.

Manami Sano

(M1, Ochanomizu Univ.)

I work on strain maintenance and phenotypic analysis of genetically modified mice.
My hobby is watching sports.

Reasearch Associate / Technician

Naoko Kakusho

Rino Fukatsu

Noriko Wada

Yoshiyo Kato

Secretary

Akiko Minagawa

I am a secretary in a Genome Dynamics Project. My work mainly involves accounting, preparing and submitting documents and placing orders. There are many students in the Genome Dynamics Project, so I get a lot of motivation and enjoy it.
My hobbies are travelling, walking and eating.

Satoko Ikeba

External research collaborator

Cooperative Researchers

  • Kenji Moriyama
  • So Maezawa
  • Motoshi Hayano

Visiting Researcher

  • Shouitirou Miyatake
  • Osamu Kaminuma

Graduates

  • Hao-Wen Hsiao
  • Kosuke Yamazaki
  • Li Bingyi
  • Yang Kisyuni
  • Tomoko Sagi
  • ZHENG WANXIN

© IGAKUKEN[Genome Dynamics Project]