主要研究業績

1) 原著論文

  1. Kobayashi K, Mizuta K, Koike S: Heparan sulfate attachment receptor is a major selection factor for attenuated enterovirus 71 mutants during cell culture adaptation. PLoS Pathog. 16(3):e1008428. 2020
    doi: 10.1371/journal.ppat.1008428.
  2. Chu ST, Kobayashi K, Bi X, Ishizaki A, Tran TT, Phung TTB, Pham CTT, Nguyen LV, Ta TA, Khu DTK, Agoh M, Pham AN, Koike S, Ichimura H: Newly emerged enterovirus-A71 C4 sublineage may be more virulent than B5 in the 2015-2016 hand-foot-and-mouth disease outbreak in northern Vietnam. Sci Rep. 10(1):159. 2020.
    doi: 10.1038/s41598-019-56703-5.
  3. Imura A, Sudaka Y, Takashino A, Tamura K, Kobayashi K, Nagata N, Nishimura H, Mizuta K, Koike S: Development of an Enterovirus 71 Vaccine Efficacy Test Using Human Scavenger Receptor B2 Transgenic Mice. J Virol. 94(6) e01921-19, 2020. doi: 10.1128/JVI.01921-19.
  4. Kobayashi K, Sudaka Y, Takashino A, Imura A, Fujii K, Koike S:Amino acid variation at VP1-145 of enterovirus 71 determines attachment receptor usage and neurovirulence in human scavenger receptor B2 transgenic mice. J. Virol. 92(15) e00681-18, 2018
  5. Fujii K, Sudaka Y, Takashino A, Kobayashi K, Kataoka C, Suzuki T, Iwata-Yoshikawa N, Kotani O, Ami Y, Shimizu H, Nagata N, Mizuta K, Matsuzaki Y, Koike S : VP1 amino acid residue 145 of enterovirus 71 is a key residue for its receptor attachment and resistance to neutralizing antibody during cynomolgus monkey infection. J. Virol. 92(15) e00682-18, 2018
  6. Kotani O, Iwata-Yoshikawa N, Suzuki T, Sato Y, Nakajima N, Koike S, Iwasaki T, Sata T, Yamashita T, Minagawa H, Taguchi F, Hasegawa H, Shimizu H, *Nagata N:Establishment of a panel of in-house polyclonal antibodies for the diagnosis of enterovirus infections.  doi: 10.1111/neup.12171 Neuropathology.35:107-121, 2014
  7. Fujii K, Nagata N, SatoY, Ong KC, Wong KT, Yamayoshi S, Shimanuki M, Shitara H, Taya C, Koike S.: Transgenic mouse model for the study of enterovirus 71 neuropathogenesis. Proc. Natl. Acad. Sci. USA. 110: 14753-14758, 2013
  8. Ng CS, Jogi M, Yoo JS, Onomoto K, Koike S, Iwasaki T, Yoneyama M, Kato H, Fujita T.: Encephalomyocarditis virus disrupts stress granules, the critical platform for triggering antiviral innate immune responses. J. Virol. 87: 9511-9522, 2013
  9. Yamayoshi S, Ohka S, Fujii K, Koike S.: Functional Comparison of SCARB2 and PSGL1 as Receptors for Enterovirus 71. J. Virol. 87:3335-3347, 2013
  10. Yamayoshi S, Iizuka S, Yamashita T, Minagawa H, Mizuta K, Okamoto M, Nishimura H, Sanjoh S, Katsushima N, Itagaki T, Nagai Y, Fujii K, Koike S: Human SCARB2-dependent Infection by Coxsackievirus A7, A14, A16 and Enterovirus 71. J Virol. 86:5686–5696, 2012
  11. McWilliam Leitch EC, Cabrerizo M, Cardosa J, Harvala H, Ivanova OE, Koike S, Kroes AC, Lukashev A, Perera D, Roivainen M, Susi P, Trallero G, Evans DJ, Simmonds P: The association of recombination events in the founding and emergence of subgenogroup evolutionary lineages of human enterovirus 71. J Virol. 86:2676-85, 2012
  12. Abe Y, Fujii K, Nagata N, Takeuchi O, Akira S, Oshiumi H, Matsumoto M, Seya T, Koike S: The Toll-Like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice. J Virol. 86:185-94, 2012
  13. Oshiumi H, Okamoto M, Fujii K, Kawanishi T, Matsumoto M, Koike S, Seya T: The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection. J Immunol. 187:5320-5327, 2011
  14. Yamayoshi S & Koike S: Identification of the Human SCARB2 Region That Is Important for Enterovirus 71 Binding and Infection. J. Virol. 85:4937-4946, 2011
  15. Parameswaran P, Sklan E, Wilkins C, Burgon T, Samuel MA, Lu R, Ansel KM, Heissmeyer V, Einav S, Jackson W, Doukas T, Paranjape S, Polacek C, dos Santos FB, Jalili R, Babrzadeh F, Gharizadeh B, Grimm D, Kay M, Koike S, Sarnow P, Ronaghi M, Ding SW, Harris E, Chow M, Diamond MS, Kirkegaard K, Glenn JS, Fire AZ.: Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog. 6(2):e1000764, 2010
  16. Hayasaka D, Nagata N, Fujii Y, Hasegawa H, Sata T, Suzuki R, Gould EA, Takashima I, & Koike S: Mortality following peripheral infection with tick-borne encephalitis virus results from a combination of central nervous system pathology, systemic inflammatory and stress responses. Virology 390:139-150, 2009
  17. Yamayoshi S, Yamashita Y, Li J, Hanagata N, Minowa T, Takemura T, & Koike S: Scavenger receptor B2 is a cellular receptor for enterovirus 71. Nat. Med. 15:789-801. 2009
  18. Ohka S, Igarashi H, Nagata N, Sakai M, Koike S, Nochi T, Kiyono H, & Nomoto A: Establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficient in alpha/beta interferon receptor. J. Virol. 81:7902-7912, 2007
  19. Yoshikawa T, Iwasaki T, Ida-Hosomuma M, Yoneyama M, Fujita T, Horie H, Miyawaza M, Abe S, Simizu B, & Koike S: Role of the alpha/beta interferon response in the acquisition of susceptibility to poliovirus by kidney cells in culture. J. Virol. 80: 4313-4325, 2006
  20. Ida-Hosomua M, Iwasaki T, Yoshikawa T, Nagata N, Sato Y, Sata T, Yoneyama M, Fujita T, Taya C, Yonekawa H, & Koike S: The alpha/beta interferon response controls tissue tropism and pathogenicity of poliovirus. J. Virol. 79: 4460-4469, 2005
  21. Nagata N, Iwasaki T, Ami Y, Sato Y, Hatano I, Harashima A, Suzaki Y, Yoshii T, Hashikawa T, Sata T, Horiuchi Y, Koike S, Kurata T, & Nomoto A: A poliomyelitis model through mucosal infection in transgenic mice bearing human poliovirus receptor, TgPVR21.Virology. 321: 87-100, 2004
  22. Ida-Hosonuma M, SasakiY, Toyoda H, Nomoto A, Gotoh O, Yonekawa H, & Koike S: Host range of poliovirus is restricted to simians because of a rapid sequence change of the poliovirus receptor gene during evolution. Arch. Virol. 148: 29-44, 2003
  23. Ida-Hosonuma M, Iwasaki T, Taya C, Sato Y, Li J, Nagata N, Yonekawa H, & Koike S: Comparison of neuropathogenicity of poliovirus in two transgenic mouse strains expressing human poliovirus receptor with different distribution patterns. J. Gen. Virol. 83:1095-1105, 2002

2) 総説論文

  1. Kobayashi K, Koike S: Cellular receptors for enterovirus A71. J Biomed Sci. 27(1):23. 2020. doi: 10.1186/s12929-020-0615-9.
    https://www.ncbi.nlm.nih.gov/pubmed/31924205
  2. 小池智:【現代医学・生物学の先駆者たち】細菌学・ウイルス学・免疫学 野本明男(1946-2014) ポリオウイルス病原性研究の開拓者 生体の科学 70巻5号 418-419 (2019)
  3. 小池智:【ウイルス受容体の発見が臨床にもたらすこと】ポリオウイルス受容体、エンテロウイルス71受容体の臨床ウイルス学への応用 臨床とウイルス 47巻1号 46-52 (2019)
  4. 小池智:エンテロウイルス71研究の進展 医学のあゆみ 258:1149-1154 (2016)
  5. Koike S, Nagata N.: A Transgenic Mouse Model of Poliomyelitis. Methods Mol Biol. 2016;1387:129-44. doi: 10.1007/978-1-4939-3292-4_7. PubMed PMID: 26983733
  6. 小池智:ポリオウイルスの神経指向性のメカニズム Annual Review 2015神経(中外医学社)121-126 (2015)
  7. Koike S:A pH-dependent molecular switch for virion uncoating. Protein Cell, 5(9): 653–654, 2014
  8. Yamayoshi S, Fujii K, *Koike S:Receptors for enterovirus 71. doi: 10.1038/emi.2014.49 Emerg. Microbes Infect., 3(7): e53, 2014
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126179/pdf/emi201449a.pdf
  9. 小池智:ポリオウイルス感染とウイルスセンサー 臨床とウイルス 41:222-228(2013)
  10. Yamayoshi S, Fujii K, Koike S.: Scavenger receptor B2 as a receptor for hand, foot and mouth disease and severe neurological diseases. Frontiers in Virology. Vol 3. Article 32 (on line publication), 2012
    http://journal.frontiersin.org/article/10.3389/fmicb.2012.00032/abstract
  11. 小池智:ピコルナウイルスの感染初期過程 ウイルス 第61巻第2号 183-192(2011)
    http://jsv.umin.jp/journal/v61-2pdf/virus61-2_183-192.pdf
  12. Koike S, & Nomoto A. Poliomyelitis. In The Picornaviruses, ed. E. Ehrenfeld, E. Domingo, & R.P. Roos. Washington DC, ASM press. 339-351, 2010
  13. 小池智:ウイルスのトロピズム 化学療法の領域 26: 353-359 (2010)
    https://www.iyaku-j.com/iyakuj/system/M2-1/summary_viewer.php?trgid=20273

3) 受賞

  1. 「ワクチンによる世界ポリオ根絶計画への基盤的貢献」 第41回 「多ヶ谷勇記念ワクチン研究」 イスクラ奨励賞(イスクラ厚生事業団)

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