研究業績

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2015年
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2015年〜 主な研究業績

  1. Sango K, Utsunomiya K. Efficacy of glucagon-like peptide-1 mimetics for neural regeneration. Neural Reg Res, 10:1723-1724 (2015)
  2. Tsukamoto M, Niimi N, Sango K, Takaku S, Kanazawa Y, Utsunomiya K. Neurotrophic and neuroprotective properties of exendin-4 in adult rat dorsal root ganglion neurons: involvement of insulin and PI3 kinase/RhoA signaling. Histochem. Cell Biol, 144:249-259 (2015)
  3. Murakami T, Sango K, Watabe K, Niimi N, Takaku S, Li Z, Yamamura K, Sunada Y. Schwann cells contribute to neurodegeneration in transthyretin amyloidosis. J Neurochem, 134:66-74 (2015)
  4. Tsukamoto M, Sango K, Niimi N, Yanagisawa H, Watabe K, Utsunomiya K. Upregulation of galectin-3 in immortalized Schwann cells IFRS1 under diabetic conditions. Neurosci. Res, 92:80-85 (2015)
  5. Torii T, Miyamoto Y, Tago K, Sango K, Nakamura K, Sanbe A, Tanoue A, Yamauchi J. Arf6 guanine-nucleotide exchange factor cytohesin-2 binds to CCDC120 and is transported along neurites to mediate neurite growth. J Biol Chem, 289:33887-33903 (2014)
  6. Sango K, Kato K, Tsukamoto M, Niimi N, Utsunomiya K, Watabe K. Physiological and Pathological Roles of Aldose Reductase in Schwann Cells. J Mol Genet Med, S1:012 (2014)
  7. Sango K, Niimi N, Tsukamoto M, Utsunomiya K, Sakumi K, Nakabeppu Y, Kadoya T, Horie H. Chapter 4: What have we learned from cultured adult dorsal root ganglion neurons? In: Ganglion Cells: Morphology, Functional Development and Role in Disease (Ed: Vlastimil LG), Nova Science Publishers, Inc, Hauppauge, USA, pp.125-148 (2014)
  8. Sango K, Tsukamoto M, Utsunomiya K, Watabe K. Chapter 10: Spontaneously immortalized adult rodent Schwann cells as valuable tools for the study of peripheral nerve degeneration and regeneration. In: Schwann Cell Development and Pathology (Eds: Sango K, Yamauchi J), Springer Japan KK, Tokyo, Japan, pp.147-170 (2014)
  9. Watabe K, Akiyama K, Kawakami E, Ishii T, Endo K, Yanagisawa H, Sango K, Tsukamoto M. Adenoviral expression of TDP-43 and FUS genes and shRNAs for protein degradation pathways in rodent motoneurons in vitro and in vivo. Neuropathology, 34:83-98 (2014)
  10. Takaku S, Yanagisawa H, Watabe K, Horie H, Kadoya T, Sakumi K, Nakabeppu Y, Poirier F, Sango K. GDNF promotes neurite outgrowth and upregulates galectin-1 through the RET/PI3K signaling in cultured adult rat dorsal root ganglion neurons. Neurochem Int, 62:330-339 (2013)
  11. Sango K, Kawakami E, Yanagisawa H, Takaku S, Tsukamoto M, Utsunomiya K, Watabe K. Myelination in coculture of established neuronal and Schwann cell lines. Histochem. Cell Biol, 137:829-839 (2012)
  12. Sango K, Yanagisawa H, Watabe K, Horie H, Kadoya T. Chapter 3: Galectin-1 as a multifunctional molecule in the peripheral nervous system after injury. In: Basic Principles of Peripheral Nerve Disorders (Ed: Rayegani, S.M.), InTech d.o.o., Rijeka, Croatia, pp.31-46 (2012)
  13. Sango K, Yanagisawa H, Takaku S, Kawakami E, Watabe K. Immortalized adult rodent Schwann cells as in vitro models to study diabetic neuropathy. Exp. Diabetes Res, 374943 (2011)
  14. Sango K, Yanagisawa H, Kawakami E, Takaku S, Ajiki K, Watabe K. Spontaneously immortalized Schwann cells from adult Fischer rat as a valuable tool for exploring neuron-Schwann cell interactions. J Neurosci Res, 89:898–908 (2011)
  15. Yanagisawa H, Komuta Y, Kawano H, Toyoda M, Sango K. Pleiotrophin induces neurite outgrowth and up-regulates growth-associated protein (GAP-43) mRNA through the ALK/GSK3β/β-catenin signaling in developing mouse neurons. Neurosci. Res, 66:111-116 (2010)
  16. Sango K, Yanagisawa H, Komuta Y, Si Y, Kawano H. Neuroprotective properties of ciliary neurotrophic factor for cultured adult rat dorsal root ganglion neurons. Histochem Cell Biol, 140:669-679 (2008)
  17. Ibi M, Matsuno K, Shibata D, Katsuyama M, Iwata K, Kakehi T, Nakagawa T, Sango K, Shirai Y, Yokoyama T, Kaneko S, Saito N, Yabe-Nishimura C. Reactive oxygen species derived from NOX1/NADPH oxidase enhance inflammatory pain. J Neurosci, 28:9486-9494 (2008)
  18. Sango K, Yanagisawa H, Takaku S. Expression and histochemical localization of ciliary neurotrophic factor in cultured adult rat dorsal root ganglion neurons. Histochem Cell Biol, 128:35-43 (2007)
  19. Sango K, Suzuki T, Yanagisawa H, Takaku S, Hirooka H, Tamura M, Watabe K. High glucose-induced activation of the polyol pathway and changes of gene expression profiles in immortalized adult mouse Schwann cells IMS32. J Neurochem, 98:446-458 (2006)
  20. Sango K, Takano M, Ajiki K, Tokashiki A, Arai N, Kawano H, Horie, H, Yamanaka S. Impaired neurite outgrowth in the retina of a murine model of Sandhoff disease. Invest Opththalmol Vis Sci, 46:3420-3425 (2005)
  21. Horie H, Kadoya T, Hikawa N, Sango K, Takeshita K, Asawa R, Hiroi T, Sato M, Yoshioka T, Ishikawa Y. Oxidized galectin-1 stimulates macrophages to promote axonal regeneration in peripheral nerves after axotomy. J Neurosci, 24:1673-1680 (2004)
  22. Sango K, Tokashiki A, Ajiki K, Horie M, Kawano H, Watabe K, Horie, H, Kadoya T. Synthesis, localization and externalization of galectin-1 in mature dorsal root ganglion neurons and Schwann cells. Eur J Neurosci, 19:55-64 (2004)
  23. Sango K, Oohira A, Ajiki K, Tokashiki A, Horie M, Kawano H. Phosphacan and neurocan are repulsive substrata for adhesion and neurite extension of adult rat dorsal root ganglion neurons in vitro. Exp Neurol, 182:1-11 (2003)
  24. Sango K, Horie H, Saito H, Ajiki K, Tokashiki A, Takeshita K, Ishigatsubo Y, Kawano H, Ishikawa Y. Diabetes is not a potent inducer of neuronal cell death in mouse sensory ganglia, but it enhances neurite regeneration in vitro. Life Sci, 71: 2351-2368 (2002)
  25. Sango K, Yamanaka S, Ajiki K, Tokashiki A. Watabe K. Lysosomal storage results in impaired survival but normal neurite outgrowth in dorsal root ganglion neurons from a mouse model of Sandhoff disease. Neuropathol Appl Neurobiol, 28:23-34 (2002)
  26. Kawai H, Allende ML, Wada R, Kono M, Sango K, Deng C, Miyakawa T, Crawley JN, Werth N, Bierfreund U, Sandhoff K, Proia RL. Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures. J Biol Chem, 276:6885-6888 (2001)
  27. Takano M, Sango K, Horie H,　Sato M, Iijima Y, Ohno S, Inoue S, Ishikawa Y. Diabetes alters neurite regeneration from mouse retinal explants in culture. Neurosci Lett, 275:175-178 (1999)
  28. Sango K, Horie H, Inoue S. Administration of an aldose reductase inhibitor, ONO-2235, to streptozotocin-diabetic mice restores reductions of DRG neuronal attachment to extracellular matrix proteins in vitro. Neurosci Lett, 263:157-160 (1999)
  29. LiuY, Wada R, Kawai H, Sango K, Deng C, Tai T, McDonald MP, Araujo K, Crawley JN, Bierfreund U, Sandhoff K, Suzuki K, Proia RL. A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder. J Clin Invest, 103:497-505 (1999)
  30. Kawai H, Sango K, Mullin KA, Proia RL. Embryonic stem cells with a disrupted GD3 synthase gene undergo neuronal differentiation in the absence of b-series gangliosides. J Biol Chem, 273:19634-19638 (1998)
  31. Suzuki K, Sango K, Proia RL, Langaman C. Mice deficient in all forms of lysosomal β-hexosaminidase: Unique pathological features in a novel form of mucopolysaccharidosis. J Neuropathol Exp Neurol, 56:693-703 (1997)
  32. Sango K, Mcdonald MP, Crawley JN, Mack ML, Tifft CJ, Skop E, Starr CM, Hoffman A, Sandhoff K, Suzuki K, Proia RL. Mice lacking both subunits of lysosomal β-hexosaminidase display gangliosidosis and mucopolysaccharidosis. Nat Genet, 14:348-352 (1996)
  33. Sango K, Yamanaka S, Hoffman A, Okuda Y, Grinberg A, Westphal H, Mcdonald MP, Crawley JN, Sandhoff K, Suzuki K, Proia RL. Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism. Nat Genet, 11:170-176 (1995)
  34. Sango K, Verdes JM, Hikawa N, Horie H, Tanaka S, Inoue S, Sotelo JR, Takenaka T. Nerve growth factor (NGF) restores depletions of calcitonin gene-related peptide and substance P in sensory neurons from diabetic mice in vitro. J Neurol Sci, 129:1-5 (1994)

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