2020.11.27: Dr. Ouchi's paper "Calpain-2 participates in the process of calpain-1 inactivation." has been published in Biosci Rep.

2020. 9. 9: Dr. Irie's paper "An artificial cationic oligosaccharide combined with phosphorothioate linkages strongly improves siRNA stability." has been published in Sci Rep.

2020. 9. 4: Dr. Ojima's paper "Developing fluorescence sensor probe to capture activated muscle-specific calpain-3 (CAPN3) in living muscle cells." has been published in Biol Open.

2020. 7. 1: Dr. Hata's paper "A muscle-specific calpain, CAPN3, forms a homotrimer." has been published in Biochim Biophys Acta Proteins Proteom.

2019. 2.1："Calpacchopper" has become more user-friendly. Click'n chop!

2017.11.02: Our calpain proteolysis site predictor "Calpacchopper" has been implemented at our CaMPDB web site.
　　　　　　

2016.12.21: Dr. Ono's Japanese review paper"Does calpain inhibition always rescue us?" has been published in SEIKAGAKU.
　　　　　　

2016.12.01: Dr. Ono's paper "Calpain research for drug discovery: challenges and potential" has been published in Nat Rev Drug Disc (accepted on 2016.09.23) (Article：view only, Supplementary information: ～3MB ).

2016.12.30: Dr. Hata's paper "A gastrointestinal calpain complex, G-calpain, is a heterodimer of CAPN8 and CAPN9, which play catalytic and regulatory roles, respectively" has been published in J Biol Chem (accepted on 2016.11.23).

2016.04.01: Dr. Ouchi's paper ""Predictions of cleavability of calpain proteolysis by quantitative structure-activity relationship analysis using newly determined cleavage sites and catalytic efficiencies of an oligopeptide array" has been published in Mol Cell Proteomics (accepted on 2016.01.21).

2016.03.01: Our paper "An eccentric calpain, CAPN3/p94/calpain-3" has been published in Biochimie (accepted on 2015.09.07).

2015.10.15: PJ leader's Japanese review paper "Calpain" has been published in Seitai-no-Kagaku.

2014.12.23: Dr. Ono's paper "The N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation" has been published in PNAS (accepted on 2014.11.5).

2014.11.06: Dr. Ojima's paper "Muscle-specific calpain-3 is phosphorylated in its unique insertion region for enrichment in a myofibril fraction" has been published in Genes Cells (accepted on 2014.8.20).

2013.10.21-25: The 8th IPS (International Proteolysis Society) General Meeting was held in Cape Town, South Africa.

2013.07.21-26: FASEB Summer Research Conference - Calpains Function in Biology and Disease was held in Saxtons River, Vermont, USA.

2013.08.01: Dr. Tonami's paper "Calpain-6 deficiency promotes skeletal muscle development and regeneration" has been published in PLoS Genet.

2012.09.22-26: XIIIth International Symposium on Proteinases, Inhibitors and Biological Control was held in Portorož, Slovenia, and Dr. Ono was awarded "The Best Poster Award" (1 out of all poster presenters).

2012.09.1-5: 41st EMC (European Muscle Conference) 2012 was held in Rohdes, Greece, and Dr. Ono was awarded "Young Investigator Award for Poster Presentation" (2 out of 101 poster presenters).

2012.07.23: Our review article "Understanding the substrate specificity of conventional calpains" (collaboration with Prof. Hiroshi Mamitsuka at Kyoto Univ.) has been accepted for publication in Biol. Chem. (pdf: ~7 MB)

2012.05.26: Total Article View of Dr. Hata's paper "Calpain 8/nCL-2 and calpain 9/nCL-4 Constitute an Active Protease Complex, G-Calpain, Involved in Gastric Mucosal Defense" publisched in PLoS Genetics in 2010 has exceeded 3,000 (pdf: Open access ～4.7 MB）

2012.04.24: Dr. Ono's review paper "Regulation and physiological roles of the calpain system in muscular disorder" has been accepted for publicaton in Cardiovasc. Res. (pdf: Open access ~12 MB)

2012.04.01: A new member, Dr. Fumiko Ouchi, has joined us.

2011.12.20: Dr. Hata's paper "Efficient expression and purification of recombinant human m-calpain using an Escherichia coli expression system at low temperature" has been accepted for publication in J Biochem (pdf: ~2 MB)

2011.08.06: Dr. Ono's review paper "Calpains - an elaborate proteolytic system" has been accepted for publication in Biochim Biophys Acta (pdf: Open access ~6.5 MB)

2011.07.01: Our review paper "Impact of genetic insights into calpain biology" has been published in J Biochem (pdf: Open access ~1.2 MB)

2011.06.13: Our review paper "Calpain chronicle" has been published in Proc Jpn Acad Ser B (pdf: Open access ~4.8 MB)

2011.06.06: Drs. Sáenz and Ono's original paper "Does the severity of the LGMD2A phenotype in compound heterozygotes depend on the combination of mutations?" has been published on-line in Muscle Nerve (pdf is available here ~2.2 MB)

2011.04.15: Dr. Tonami's original paper "Calpain 6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1"has been published in J Cell Sci.

2011.04.01: Dr. Ojima's original paper "Non-proteolytic functions of calpain-3 in sarcoplasmic reticulum in skeletal muscles" has been published in J Mol Biol (pdf: NIH free public access ~1.8 MB)

2011.04.01: Our institute has been renovated to a new organization, and our calpain project with new members has started.

^{*****************}
Recent progress (1): CAPN3 was shown to be the first example of Na⁺-dependent intracellular enzyme.

Recent progress (2): CAPN3 moves around inside skeletal muscle cells.

Recent progress (3): G-calpain is a complex of CAPN8 and CAPN9, protecting the stomach.