Shusaku Masuda, Rajesh Narasimamurthy, Hikari Yoshitane, Jae Kyoung Kim, Yoshitaka Fukada, and David M. Virshup Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch Proc. Natl. Acad. Sci. USA 117(20): 10888-10896 (2020) doi: 10.1073/pnas.2000266117 https://pubmed.ncbi.nlm.nih.gov/32354999/
Hikari Yoshitane* (* Co-correspondence), Yoshimasa Asano, Aya Sagami, Seinosuke Sakai, Yutaka Suzuki, Hitoshi Okamura, Wataru Iwasaki, Haruka Ozaki, and Yoshitaka Fukada* Functional D-box sequences reset the circadian clock and drive mRNA rhythms. Communications Biology 2: 300 (2019) doi: 10.1038/s42003-019-0522-3 https://pubmed.ncbi.nlm.nih.gov/31428688/
Kiyomichi Imamura, Hikari Yoshitane*(* Co-correspondence), Kazuki Hattori, Mitsuo Yamaguchi, Kento Yoshida, Isao Naguro, Hidenori Ichijo and Yoshitaka Fukada* ASK family kinases mediate cellular stress and redox signaling to circadian clock Proc. Natl. Acad. Sci. USA 115(14): 3646-3651 (2018) doi: 10.1073/pnas.1719298115. https://pubmed.ncbi.nlm.nih.gov/29555767/
Shingo Hiroki*, Hikari Yoshitane*
Ror homolog nhr-23 is essential for both developmental clock and circadian clock in C. elegans Communications Biology, 7(1):243 (2024)
doi: 10.1038/s42003-024-05894-3. PMID: 38418700
研究内容の日本語紹介はこちら
Nobuhiro Kurabayashi, Kazuki Fujii, Yuta Otobe, Shingo Hiroki, Masaharu Hiratsuka, Hikari Yoshitane, Yasuhiro Kazuki, Keizo Takao
Neocortical neuronal production and maturation defects in the TcMAC21 mouse model of Down syndrome iScience, 26(12):108379 (2023)
doi: 10.1016/j.isci.2023.108379 PMID: 38025769
Yasuko O. Abe, Hikari Yoshitane* (* Co-correspondence), Dae Wook Kim, Michinori Koebis, Kazuki Nakao, Atsu Aiba, Jae Kyoung Kim and Yoshitaka Fukada*
Rhythmic transcription of Bmal1 stabilizes the circadian timekeeping system in mammals Nature Communications, 13 (1): 4652 (2022)
doi: 10.1038/s41467-022-32326-9. PMID: 35999195
Hitomi Yamamoto-Matsuda, Keita Miyoshi, Mai Moritoh, Hikari Yoshitane, Yoshitaka Fukada, Kuniaki Saito, Soichiro Yamanaka, Mikiko C Siomi
Lint-O cooperates with L(3)mbt in target gene suppression to maintain homeostasis in fly ovary and brain. EMBO Rep., e53813, Online ahead of print. (2022)
doi: 10.15252/embr.202153813. PMID: 35993198
Shusaku Masuda, Rajesh Narasimamurthy, Hikari Yoshitane, Jae Kyoung Kim, Yoshitaka Fukada, and David M. Virshup Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch Proc. Natl. Acad. Sci. USA 117(20): 10888-10896 (2020) doi: 10.1073/pnas.2000266117
Hikari Yoshitane* (* Co-correspondence), Yoshimasa Asano, Aya Sagami, Seinosuke Sakai, Yutaka Suzuki, Hitoshi Okamura, Wataru Iwasaki, Haruka Ozaki, and Yoshitaka Fukada*
Functional D-box sequences reset the circadian clock and drive mRNA rhythms. Communications Biology 2: 300 (2019) doi: 10.1038/s42003-019-0522-3
Arisa Hirano, Tomoki Nakagawa, Hikari Yoshitane, Masaaki Oyama, Hiroko Kozuka- Hata, Darin Lanjakornsiripan, and Yoshitaka Fukada.
USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock. PLoS One, 11(4): e0154263 (2016) doi: 10.1371/journal.pone.0154263.
Michal Dudek, Nicole Gossan, Nan Yang, Hee-Jeong Im, Jayalath PD Ruckshanthi, Hikari Yoshitane, Xin Li, Ding Jin, Ping Wang, Maya Boudiffa, Ilaria Bellantuono, Yoshitaka Fukada, Ray P. Boot-Handford, and Qing-Jun Meng.
The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity The Journal of Clinical Investigation, 126(1): 365-376 (2016) doi:10.1172/JCI82755
Naohiro Kon, Yasunori Sugiyama, Hikari Yoshitane, Isamu Kameshita, and Yoshitaka Fukada
Cell-based inhibitor screening identifies period-tuning kinases and essential components of the circadian clock Communicative & Integrative Biology, 8(4): e982405 (2015) doi: 10.4161/19420889.2014.982405
Naohiro Kon, Tomoko Yoshikawa, Sato Honma, Yoko Yamagata, Hikari Yoshitane, Kimiko Shimizu, Yasunori Sugiyama, Chihiro Hara, Isamu Kameshita, Kenichi Honma and Yoshitaka Fukada
CaMKII is essential for the cellular clock and coupling between morning and evening behavioral rhythms. Genes and Development, 28(10): 1101-1110 (2014) doi: 10.1101/gad.237511.114.
Nicole Gossan, Feng Zhang, Baoqiang Guo, Ding Jin, Hikari Yoshitane, Aiyu Yao, Nick Glossop, Yong Q Zhang, Yoshitaka Fukada, and Qing-Jun Meng
The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor Nucleic Acids Research, 42(9): 5765-5775 (2014) doi: 10.1093/nar/gku225.
Vanja Pekovic-Vaughan, Julie Gibbs, Hikari Yoshitane, Nan Yang, Dharshika Pathiranage, Baoqiang Guo, Aya Sagami, Keiko Taguchi, David Bechtold, Andrew Loudon, Masayuki Yamamoto, Jefferson Chan, Gijsbertus T.J. van der Horst, Yoshitaka Fukada, and Qing-Jun Meng
The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. Genes and Development, 28(6): 548-560 (2014) doi: 10.1101/gad.237081.113
Hikari Yoshitane, Haruka Ozaki, Hideki Terajima, Ngoc-Hien Du, Yutaka Suzuki, Taihei Fujimori, Naoki Kosaka, Shigeki Shimba, Sumio Sugano, Toshihisa Takagi, Wataru Iwasaki, and Yoshitaka Fukada
CLOCK-controlled polyphonic regulations of circadian rhythms through canonical and non-canonical E-boxes. Molecular and Cellular Biology, 34(10): 1776-1787 (2014) doi: 10.1128/MCB.01465-13
Hikari Yoshitane, Sato Honma, Kiyomichi Imamura, Hiroto Nakajima, Shin-ya Nishide, Daisuke Ono, Hiroshi Kiyota, Naoya Shinozaki, Hirokazu Matsuki, Naoya Wada, Hirofumi Doi, Toshiyuki Hamada, Ken-ichi Honma and Yoshitaka Fukada
JNK regulates the photic response of the mammalian circadian clock. EMBO Reports, 13(5): 455-461 (2012) doi: 10.1038/embor.2012.37
Hikari Yoshitane, Toshifumi Takao, Yoshinori Satomi, Ngoc-Hien Du, Toshiyuki Okano, and Yoshitaka Fukada
Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription. Molecular and Cellular Biology, 29(13): 3675-3686 (2009) doi: 10.1128/MCB.01864-08
Momoko Sasaki, Hikari Yoshitane, Ngoc-Hien Du, Toshiyuki Okano, and Yoshitaka Fukada
Preferential Inhibition of BMAL2-CLOCK Activity by PER2 Reemphasizes Its Negative Role and a Positive Role of BMAL2 in the Circadian Transcription. J. Biol. Chem., 284(37): 25149-25159 (2009) doi: 10.1074/jbc.M109.040758
Hikari Yoshitane and Yoshitaka Fukada
CIPC-dependent phosphorylation of CLOCK and NPAS2 in circadian clockwork Sleep and Biological Rhythms, 7(4): 226-234 (2009)
Hikari Yoshitane and Yoshitaka Fukada
Protein modifications pace the circadian oscillation of biological clocks
「Protein Modifications in Pathogenic Dysregulation of Signaling」p251-p268, Springer, (2015)