Technology Licensing Office

List of assets from TMiMS

No.	Field	Title	Description	Keywords, Other
1	CNS	Cellular and animal models in neurodegenerative diseases	"Cellular and animal models in the neurodegenrative diseases show the accumulation of abnormal protein of Tau, α-synuclein, or TDP-43. These disease models are useful for the screening of medicines in neurodegenerative disease such as AD, DLB, PD, and ALS."	AD, DLB, PD, ALS, Tau, α-synuclein, TDP-43,
2	CNS	A drug candidate compound for autism and intellectual disorder.	We found a protein regulating dendritic spine formation in hippocampal neurons. Administration of Compound X to model animals restored spine abnormalities, intellectual disorders and behavior deficits.	Spine formation, Drug repositioning Tuberous sclerosis complex, Autism, Intellectual disorder,
3	CNS	Neuropathology Database and web contents for collaborative research, E-learning, and development of automated diagnosis	We have more than 5,000 human brain specimens of neurological diseases, as well as high resolution WSI (whole slide images) organized into a library of neuropathological disorders. Our Neuropathology Database and web contents can be utilized for various collaborative research and education / training activities. In particular, we seek collaborations to develop automated systems to characterize and diagnose neurologic disease pathologies.	Digital Neuropathology, WSI (whole slide images) , Automated diagnosis, Neuropathological specimens
4	Protein Degradation	"TR-TUBE Method" for detection of E3-specific ubiquitin substrates	An useful method for detection of ubiquitinated substrates efficiently and stably from cultured cells overexpressing a specific ubiquitin ligase E3.	Ubiquitination, Ubiquitin ligase E3, Ubiqutinated substrate
5	Autophagy	Atg7 cKO mouse	A conditional knockout mouse in which the function of a gene causative of autophagy (Atg7) is entirely or partly impaired depending on Cre recombinase. This mouse proves useful in analyzing disorders in which autophagy is involved.	Autophagy, Ubiquitin, Atg7
6	Protein Degradation	A Biomarker for Parkinson's Disease（Phosphorylated Ubiquitin and It's Antibody Related to PINK1 and Parkin）	This is an antibody targeting phosphorylated ubiquitin, which serves as a biomarker for Parkinson’s disease.　 Mitochondria, which synthesize ATP, are constantly undergoing cycles of fission and fusion. Phosphorylated ubiquitin has been found to be involved in the metabolic pathway of PINK1 and Parkin, which are mitochondrial quality control factors. As the accumulation of abnormal mitochondria is a contributing factor to the onset of Parkinson’s disease, antibodies that detect phosphorylated ubiquitin involved in this pathway may serve as potential biomarkers for the disease.	phosphorylated ubiquitin,Parkinson's disease,mitochondrial,PINK1 , Parkin
7	Genome Editing	RAPID-CRISPR-Rapid Activation of Genome-Editing Enzyme-	We have developed RAPID*-CRISPR, which combines anti-CRISPR protein and ligand-inducible degron to rapidly activate the CRISPR/Cas system. We rapidly suppressed transcription of cancer-associated noncoding RNAs (lncRNAs), and succeeded in identifying gensewhose expression changed concurrently. We expect that this technology is useful for exploring therapeutic targets for cancer. *RAPID: Regulation by Anti-CRISPR Proteins via Inducible Degradation	CRISPR/Cas, Rapid activation
8	Drg Discovery Technology	Tetraploid Cardiomyocytes-Application to the Cardiotoxicity Evaluation-	We have developed tetraploid (4N) human iPScells by fusing diploid (2N) cells. 4N iPScells can differentiate into 4N cardiomyocytes. These cells exhibited, compared with conventional 2N cardiomyocytes, increased mitochondrial content, stronger contractile force, faster contraction velocity, and resistance to cardiotoxic drugs. We expect that 4N cardiomyocytes can be used for cardiotoxicity evaluation.	Tetraploid iPScells, Tetraploid cardiomyocytes,Cardiotoxicity Evaluation