Technology Licensing Office

List of assets from TMiMS

Members

No.	Field	Title	Description	Keywords, Other
1	Nerve (nerve center)	Cellular and animal models in neurodegenerative diseases	Cellular and animal models in the neurodegenrative diseases show the accumulation of abnormal protein of Tau, α-synuclein, or TDP-43. These disease models are useful for the screening of medicines in neurodegenerative disease such as AD, DLB, PD, and ALS.	AD, DLB, PD, ALS, Tau, α-synuclein, TDP-43,
2	Nerve (nerve center)	A drug candidate compound for autism and intellectual disorder.	We found a protein regulating dendritic spine formation in hippocampal neurons. Administration of Compound X to model animals restored spine abnormalities, intellectual disorders and behavior deficits.	Spine formation, Drug repositioning Tuberous sclerosis complex, Autism, Intellectual disorder,
3	Nerve (nerve center)	Neuropathology Database and web contents for collaborative research, E-learning, and development of automated diagnosis	We have more than 5,000 human brain specimens of neurological diseases, as well as high resolution WSI (whole slide images) organized into a library of neuropathological disorders. Our Neuropathology Database and web contents can be utilized for various collaborative research and education / training activities. In particular, we seek collaborations to develop automated systems to characterize and diagnose neurologic disease pathologies.	Digital Neuropathology, WSI (whole slide images) , Automated diagnosis, Neuropathological specimens
4	Dermatology	A novel topical treatment that is specific to Epidermal Hyperplasia Symptom	Lysoplasmalogen-specific Phospholipase D (LyPls-PLD) suppresses / improves the thickened epidermis in rodent models of both psoriasis and atopic dermatitis by hydorolyzing Lysoplasmalogen molecule P-LPE. The LyPls-PLD can be a novel topical treatment that improves specifically epidermal hyperplasia.	Epidermal hyperplasia, Skin barrier, Phospholipase, Lysoplasmalogen
5	Protein Degradation	"TR-TUBE Method" for detection　of E3-specific ubiquitin substrates	An useful method for detection of ubiquitinated substrates efficiently and stably from cultured cells overexpressing a specific ubiquitin ligase E3.	Ubiquitination, Ubiquitin ligase E3, Ubiqutinated substrate
6	Autophagy	Atg7 cKO mouse	A conditional knockout mouse in which the function of a gene causative of autophagy (Atg7) is entirely or partly impaired depending on Cre recombinase. This mouse proves useful in analyzing disorders in which autophagy is involved.	Autophagy, Ubiquitin, Atg7
7	Rare Diseases	“Modified NAGA (Mod. NAGA)” ~A Novel Enzyme for Fabry Disease~	Mod. NAGA, which shows GLA activity, was developped by modifying two amino acids of NAGA. Mod. NAGA does not react to serum from Fabry patients treated with a recombinant GLA. Mod. NAGA is a highly promising novel enzyme for ERT and Cell Therapy for Fabry disease.	Fabry disease, Modified enzyme, Avoidance of immunoreactions, Enzyme replacement therapy (ERT), Cell therapy
8	Medical Equipment	A novel quantitative / functional evaluation system for movement disorders	The classical neurological examination is not suitable to develop a new treatment because it is poorly quantitative and recordable. We proposed a functional evaluation system for movement disorders. Our system could provide an optimal treatment program for each patients with neurological movement disorders.	PD, Stroke, SCD(Spinocerebellar degeneration), Patient's, condition evaluation,