Research Support TOP Basic Tech TLO TR

Technology Licensing Office

List of assets from TMiMS

  • Patent and license the research discovery
  • Manage joint/contracted researches with private corporations, and promote cooperation and coordination between industry-academia-government
  • Plan and organize meetings of our researchers with private corporations and other organizations
  • Search for "Research Seeds" generated at the institute


No. Field Title Description Keywords, Other
1 Nerve
(nerve center)
Cellular and animal models in neurodegenerative diseases Cellular and animal models in the neurodegenrative diseases show the accumulation of abnormal protein of Tau, α-synuclein, or TDP-43. These disease models are useful for the screening of medicines in neurodegenerative disease such as AD, DLB, PD, and ALS. AD, DLB, PD, ALS, Tau, α-synuclein, TDP-43,
2 Nerve
(nerve center)
A drug candidate compound for autism and intellectual disorder. We found a protein regulating dendritic spine formation in hippocampal neurons. Administration of Compound X to model animals restored spine abnormalities, intellectual disorders and behavior deficits. Spine formation, Drug repositioning Tuberous sclerosis complex, Autism, Intellectual disorder,
3 Nerve
(nerve center)
Neuropathology Database and web contents for collaborative research, E-learning, and development of automated diagnosis We have more than 5,000 human brain specimens of neurological diseases, as well as high resolution WSI (whole slide images) organized into a library of neuropathological disorders. Our Neuropathology Database and web contents can be utilized for various collaborative research and education / training activities. In particular, we seek collaborations to develop automated systems to characterize and diagnose neurologic disease pathologies. Digital Neuropathology, WSI (whole slide images) , Automated diagnosis, Neuropathological specimens
4 Dermatology A novel topical treatment that is specific to Epidermal Hyperplasia Symptom Lysoplasmalogen-specific Phospholipase D (LyPls-PLD) suppresses / improves the thickened epidermis in rodent models of both psoriasis and atopic dermatitis by hydorolyzing Lysoplasmalogen molecule P-LPE.
The LyPls-PLD can be a novel topical treatment that improves specifically epidermal hyperplasia.
Epidermal hyperplasia, Skin barrier, Phospholipase, Lysoplasmalogen
5 Protein
"TR-TUBE Method" for detection of E3-specific ubiquitin substrates An useful method for detection of ubiquitinated substrates efficiently and stably from cultured cells overexpressing a specific ubiquitin ligase E3. Ubiquitination, Ubiquitin ligase E3, Ubiqutinated substrate
6 Autophagy Atg7 cKO mouse A conditional knockout mouse in which the function of a gene causative of autophagy (Atg7) is entirely or partly impaired depending on Cre recombinase. This mouse proves useful in analyzing disorders in which autophagy is involved. Autophagy, Ubiquitin, Atg7
7 Rare Diseases “Modified NAGA (Mod. NAGA)”
~A Novel Enzyme for Fabry Disease~
Mod. NAGA, which shows GLA activity, was developped by modifying two amino acids of NAGA. Mod. NAGA does not react to serum from Fabry patients treated with a recombinant GLA. Mod. NAGA is a highly promising novel enzyme for ERT and Cell Therapy for Fabry disease. Fabry disease, Modified enzyme, Avoidance of immunoreactions, Enzyme replacement therapy (ERT), Cell therapy
8 Medical Equipment A novel quantitative / functional evaluation system for movement disorders The classical neurological examination is not suitable to develop a new treatment because it is poorly quantitative and recordable.
We proposed a functional evaluation system for movement disorders. Our system could provide an optimal treatment program for each patients with neurological movement disorders.
PD, Stroke, SCD(Spinocerebellar degeneration), Patient's, condition evaluation,