TOPICS 2019
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Yang-Chi-Chun and Hisao Masai (Genome Dynamics Project) published a paper entitled ”Cdc7 activates replication checkpoint by phosphorylating the Chk1 binding domain of Claspin in human cells.” in eLife
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Hikaru Tsuchiya (Laboratory of Protein Metabolism) published a paper entitled “Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4” in Nature Communications.
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Miharu Nakanishi (Mental Health Promotion Project) published a paper entitled ”Midlife Psychological Well-Being and its Impact on Cognitive Functioning Later in Life: An Observational Study Using a Female British Cohort.” in Journal of Alzheimer’s Disease
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Dr. Masato Hosokawa (Dementia Research Project) was awarded the Encouragement Award (Best Basic Research) at the Japan Society for Dementia Research Annual Meeting in 2019.
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Tetsuya Hirabayashi (Laboratory of Biomembrane）published a paper entitled "SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation" in The Journal of Clinical Investigation
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Yukio Nishimura (Neural Prosthesis Project) published a paper entitled ”Bypassing stroke-damaged neural pathways via a neural interface induces targeted cortical adaptation” in Nature Communications.
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Takahiko Noro (Visual Research Project) published a paper on glaucoma-like degeneration of the visual system in aged marmosets in Scientific Reports.
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Dr. Fumika Koyano (Ubiquitin Project) published a paper on “Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes” in EMBO Reports.
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Keisuke Kamimura (Neural Network Project) published a paper entitled ”The HSPG Glypican Regulates Experience-Dependent Synaptic and Behavioral Plasticity by Modulating the Non-Canonical BMP Pathway” in Cell Reports
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Takahiro Sanada (Viral Infectious Diseases Project) published a paper on “Construction of complete Tupaia belangeri transcriptome database by whole-genome and comprehensive RNA sequencing” in Scientific Reports
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Yuki Nakayama (ALS Nursing Care Project) published a paper on “Body weight variation predicts disease progression after invasive ventilation in amyotrophic lateral sclerosis” in Scientific Reports
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Kazuhiko Namekata (Visual Research Project) published a paper on the role of DOCK8 during neurodegeneration in Journal of Biological Chemistry.
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Daisuke Yamane (Viral Infectious Diseases Project) published a paper on “Basal Expression of Interferon Regulatory Factor 1 Drives Intrinsic Hepatocyte Resistance to Multiple RNA Viruses” in Nature Microbiology
HOME ＞ Topics2019 ＞ 17 September 2019
17 September 2019
Keisuke Kamimura (Neural Network Project) published a paper entitled ”The HSPG Glypican Regulates Experience-Dependent Synaptic and Behavioral Plasticity by Modulating the Non-Canonical BMP Pathway” in Cell Reports
The HSPG Glypican Regulates Experience-Dependent Synaptic and Behavioral Plasticity by Modulating the Non-Canonical BMP Pathway
- ＜Title of the paper＞
- The HSPG Glypican Regulates Experience-Dependent Synaptic and Behavioral Plasticity by Modulating the Non-Canonical BMP Pathway
- ＜Journal＞
- Cell Reports
DOI：https://doi.org/10.1016/j.celrep.2019.08.032
https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31072-1
Summary
In Drosophila, octopamine signaling increases larval locomotor speed and synaptic bouton numbers at neuromuscular junctions under food deprivation conditions. We found that a glypican (Dally-like), the expression of which is controlled by octopamine signaling, regulates this process by modulating the activity of GluRIIA-mediated non-canonical BMP pathway.
Details
Under food deprivation conditions, Drosophila larvae exhibit increases in locomotor speed and synaptic bouton numbers at neuromuscular junctions (NMJs). Octopamine, the invertebrate counterpart of noradrenaline, plays critical roles in this process; however, the underlying mechanisms remain unclear. We show here that a glypican (Dlp) negatively regulates type I synaptic bouton formation, postsynaptic expression of GluRIIA, and larval locomotor speed. Starvation-induced octopaminergic signaling decreases Dlp expression, leading to increases in synapse formation and locomotion. Dlp is expressed by postsynaptic muscle cells, and suppresses the non-canonical BMP pathway, which is composed of the presynaptic BMP receptor Wit and postsynaptic GluRIIA-containing ionotropic glutamate receptor. We find that during starvation, decreases in Dlp increase non-canonical BMP signaling leading to increases in GluRIIA expression, type I bouton number and locomotor speed. Our results demonstrate that octopamine controls starvation-induced neural plasticity by regulating Dlp, and provides insights into how proteoglycans can influence behavioral and synaptic plasticity.
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