Achievement
研究業績
2009年
論文発表
- Foulds PG, Davidson Y, Mishra M, Hobson DJ, Humphreys KM, Taylor M, Johnson N, Weintraub S, Akiyama H, Arai T, Hasegawa M, Bigio EH, Benson FE, Allsop D, Mann DM. (2009) Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration. Acta Neuropathol. 118(5):647-58. doi: 10.1007/s00401-009-0594-0.
- Sawashita J, Kametani F, Hasegawa K, Tsutsumi-Yasuhara S, Zhang B, Yan J, Mori M, Naiki H, Higuchi K. (2009) Amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II. Biochim Biophys Acta. 1794(10):1517-29. doi: 10.1016/j.bbapap.2009.06.028.
- Nonaka T, Hasegawa M. (2009) A Cellular Model To Monitor Proteasome Dysfunction by alpha-Synuclein. Biochemistry. 48(33):8014-22. doi: 10.1021/bi900619j.
- Yamashita M, Nonaka T, Arai T, Kametani F, Buchman VL, Ninkina N, Bachurin SO, Akiyama H, Goedert M, Hasegawa M.(2009) Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models. FEBS Lett. 583(14):2419-24. doi: 10.1016/j.febslet.2009.06.042.
- Nonaka T, Kametani F, Arai T, Akiyama H, Hasegawa M. (2009) Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43. Hum Mol Genet. 18(18):3353-64. doi: 10.1093/hmg/ddp275.
- Yotsumoto K, Saito T, Asada A, Oikawa T, Kimura T, Uchida C, Ishiguro K, Uchida T, Hasegawa M, Hisanaga SI. (2009) Effect of PIN1 or microtubule binding on dephosphorylation of FTDP-17 mutant TAU. J Biol Chem. 284(25):16840-7. doi: 10.1074/jbc.M109.003277.
- Davidson Y, Amin H, Kelley T, Shi J, Tian J, Kumaran R, Lashley T, Lees AJ, Duplessis D, Neary D, Snowden J, Akiyama H, Arai T, Hasegawa M. Bandopadhyay R, Sikkink S, Pickering-Brown S, Mann DM. (2009) TDP-43 in ubiquitinated inclusions in the inferior olives in frontotemporal lobar degeneration and in other neurodegenerative diseases: a degenerative process distinct from normal ageing. Acta Neuropathol. 118(3):359-69. doi: 10.1007/s00401-009-0526-z.
- Kume H, Konishi Y, Murayama KS, Kametani F, Araki W. (2009) Expression of reticulon 3 in Alzheimer's disease brain. Neuropathol Appl Neurobiol. 35(2):178-88. doi: 10.1111/j.1365-2990.2008.00974.x.
- Yonetani M, Nonaka T, Masuda M, Inukai Y, Oikawa T, Hisanaga SI, Hasegawa M. (2009) Conversion of wild-type alpha -synuclein into mutant-type fibrils and its propagation in the presence of A30P mutant. J Biol Chem. 284(12):7940-50. doi: 10.1074/jbc.M807482200.
- Araki W, Kume H, Oda A, Tamaoka A, Kametani F. (2009) IGF-1 promotes beta-amyloid production by a secretase-independent mechanism. Biochem Biophys Res Commun. 380(1):111-4. doi: 10.1016/j.bbrc.2009.01.044.
- Masuda M, Hasegawa M, Nonaka T, Oikawa T, Yonetani M, Yamaguchi Y, Kato K, Hisanaga S, Goedert M. (2009) Inhibition of a-synuclein fibril assembly by small molecules: analysis using epitope-specific antibodies. FEBS Lett. 583(4):787-91. doi: 10.1016/j.febslet.2009.01.037.
- Schwab C, Arai T, Hasegawa M, Akiyama H, Yu S, McGeer PL. (2009) TDP-43 pathology in familial British dementia. Acta Neuropathol. 118(2):303-11. doi: 10.1007/s00401-009-0514-3.
- Kametani F, Nonaka T, Suzuki T, Arai T, Dohmae N, Akiyama H, Hasegawa M. (2009) Identification of casein kinase-1 phosphorylation sites on TDP-43. Biochem Biophys Res Commun. 382(2):405-9. doi: 10.1016/j.bbrc.2009.03.038.
- Arai T, Mackenzie IRA, Hasegawa M, Nonaka T, Niizato K, Tsuchiya K, Iritani S, Onaya M, Akiyama H. (2009) Phosphorylated TDP-43 in Alzheimer’s disease and dementia with Lewy bodies. Acta Neuropathol. 117(2):125-36. doi: 10.1007/s00401-008-0480-1.
- Fujishiro H, Uchikado H, Arai T, Hasegawa M, Akiyama H, Yokota O, Tsuchiya K, Togo T, Iseki E. (2009) Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease. Acta Neuropathol. 117(2):151-8. doi: 10.1007/s00401-008-0463-2.
- Nonaka T, Arai T, Buratti E, Baralle FE, Akiyama H, Hasegawa M. (2009) Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells. FEBS Lett. 583(2):394-400. doi: 10.1016/j.febslet.2008.12.031.
- 長谷川成人. 企画/編集, 概論-因子から解明される神経変性疾患の分子基盤. 実験医学 27: 1318-1323, 2009.
- 新井哲明, 長谷川成人, 野中隆, 藤城弘樹, 内門大丈, 秋山治彦. 神経変性疾患の新規原因分子:TDP-43. 実験医学 27: 1324-1332, 2009.
- 野中隆, 新井哲明, 長谷川成人. 神経変性疾患の細胞病理学. 細胞工学 28: 437-442, 2009.
- 野中隆, 新井哲明, 長谷川成人, 細胞内TDP-43蓄積のメカニズム. BRAIN and NERVE 61: 1292-1300
- 野中隆, 新井哲明, 秋山治彦, 長谷川成人. TDP-43の細胞内封入体形成モデルの作製. Dementia Japan 22: 252-260, 2009.
- 長谷川成人, 野中隆, 新井哲明. 神経変性疾患とTDP-43. 最新医学 64: 125-131,2009.
- 野中隆, 犬飼由紀, 新井哲明, 長谷川成人. TDP-43と神経変性疾患. BRAIN and NERVE 61: 161-166, 2009
- 吉田裕孝, 長谷川成人. FTDP-17の発見と遺伝子変異. Clin Neurosci 27: 271-274, 2009.
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学会発表等
招待講演
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長谷川成人:プロテオミクス解析からALS/FTLDの病態解明、治療へ. 第5回プロテオミクス・構造生物学講演会, 東京 . [2009.11.2]
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長谷川成人:変性疾患に蓄積する異常タンパク質の生化学解析とモデルの構築 [講演]. 神経変性疾患コンソーシアム 2009: TDP-43プロテイノパチー最新の知見, 東京 . [2009.9.20]
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長谷川成人:TDP-43蓄積症の概念と病態解明への展望. 第50回日本神経学会総会, 教育講演, 仙台 . [2009.5.22]
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