Achievement
研究業績
2013年
論文発表
- Hasegawa M, Watanabe S, Kondo H, Akiyama H, Mann DMA, Saito Y and Murayama S. (2013) 3R and 4R tau isoforms in paired helical filaments in Alzheimer's disease. Acta Neuropathologica. 127:318-24
- Mann DMA, Rollinson S, Robinson AC, Callister J, Snowden JS, Gendron T, Petrucelli L, Masuda-Suzukake M, Hasegawa M, Davidson YS and Pickering-Brown S. (2013) Dipeptide repeat proteins are present in the p62 positive inclusions in patients with Frontotemporal Lobar Degeneration and Motor Neurone Disease associated with expansions in C9ORF72. Acta Neuropathologica Communications. 1:68.
- Hosokawa M, Arai T, Yamashita M, Tsuji H, Nonaka T, Masuda-Suzukake M, Tamaoka A, Hasegawa M, Akiyama H. (2013) Differential diagnosis of amyotrophic lateral sclerosis from Guillain-Barre syndrome by quantitative determination of TDP-43 in cerebrospinal fluid. Int J Neurosci. 2013 Sep 26. [Epub ahead of print]
- Kobayashi Z, Kawakami I, Arai T, Yokota O, Tsuchiya K, Kondo H, Shimomura Y, Haga C, Aoki N, Hasegawa M, Hosokawa M, Oshima K, Niizato K, Ishizu H, Terada S, Onaya M, Ikeda M, Oyanagi K, Nakano I, Murayama S, Akiyama H, Mizusawa H. (2013) Pathological features of FTLD-FUS in a Japanese population: Analyses of nine cases. J Neurol Sci. pii: S0022-510X(13)02884-0. doi: 10.1016/j.jns.2013.08.035. [Epub ahead of print]
- Foulds PG, Diggle P, Mitchell JD, Parker A, Hasegawa M, Masuda-Suzukake M, Mann DM, Allsop D. (2013) A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson's disease. Sci Rep. 3:2540. doi: 10.1038/srep02540.
- Kametani F, Ikeda SI. (2013) Proteomic analysis of leptomeningeal amyloid fibril extracts of cerebral amyloid angiopathy (CAA) patients with or without corticosteroid therapy. Amyloid. 2013 Jul 23. [Epub ahead of print]
- Tsuchiya-Suzuki A, Yazaki M, Sekijima Y, Kametani F, Ikeda S. (2013) Steady turnover of amyloid fibril proteins in gastric mucosa after liver transplantation in familial amyloid polyneuropathy. Amyloid. 20(3):156-63. doi: 10.3109/13506129.2013.807790.
- Ayaho Dan, Muneaki Takahashi, Masami Masuda-Suzukake, Fuyuki Kametani, Takashi Nonaka, Hiromi Kondo, Haruhiko Akiyama, Takao Arai, David MA Mann, Yuko Saito, Hiroyuki Hatsuta, Shigeo Murayama and Masato Hasegawa. (2013) Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer’s disease brain. Acta Neuropathologica Communications. 1:54. doi:10.1186/2051-5960-1-54.
- Rui Liu, Guang Yang, Takashi Nonaka, Tetsuaki Arai, William Jia and Max S Cynader. (2013) Reducing TDP-43 aggregation does not prevent its cytotoxicity. Acta Neuropathologica Communications. 1:49. doi:10.1186/2051-5960-1-49.
- Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann DM, Akiyama H, Hasegawa M. (2013) Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains. Cell Rep. 4(1):124-134. doi: 10.1016/j.celrep.2013.06.007.
- Moujalled D, James JL, Parker SJ, Lidgerwood GE, Duncan C, Meyerowitz J, Nonaka T, Hasegawa M, Kanninen KM, Grubman A, Liddell JR, Crouch PJ, White AR. (2013) Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress. PLoS One. 8(6):e67433.
- Masuda-Suzukake M, Nonaka T, Hosokawa M, Oikawa T, Arai T, Akiyama H, Mann DM, Hasegawa M. (2013) Prion-like spreading of pathological α-synuclein in brain. Brain. 136(Pt 4):1128-38. doi: 10.1093/brain/awt037.
- Kimura T, Tsutsumi K, Taoka M, Saito T, Masuda-Suzukake M, Ishiguro K, Plattner F, Uchida T, Isobe T, Hasegawa M, Hisanaga S. (2013) Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites. J Biol Chem. 288(11):7968-77. doi: 10.1074/jbc.M112.433326.
- Ogaki K, Li Y, Takanashi M, Ishikawa K, Kobayashi T, Nonaka T, Hasegawa M, Kishi M, Yoshino H, Funayama M, Tsukamoto T, Shioya K, Yokochi M, Imai H, Sasaki R, Kokubo Y, Kuzuhara S, Motoi Y, Tomiyama H, Hattori N. (2013) Analyses of the MAPT, PGRN, and C9orf72 mutations in Japanese patients with FTLD, PSP, and CBS. Parkinsonism Relat Disord. 19(1):15-20. doi: 10.1016/j.parkreldis.2012.06.019.
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学会発表等
招待講演
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Hasegawa M: Prion-like spreading of pathological alpha-synuclein in brain. The 4th Korea Japan Symposium, Molecular Basis of Diseases, Seoul . [2013.2.26]
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