Achievement
研究業績
2016年
論文発表
- Hasegawa M. (2016) Molecular Mechanisms in the Pathogenesis of Alzheimer's disease and Tauopathies-Prion-Like Seeded Aggregation and Phosphorylation. Biomolecules 6: 24
- Kametani F, Obi T, Shishido T, Akatsu H, Murayama S, Saito Y, Yoshida M, Hasegawa M. (2016) Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains. Sci Rep 6: 23281
- Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M. (2016) Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation. Hum Mole Genet 25: 1420-1433
- Nonaka T, Suzuki G, Tanaka Y, Kametani F, Hirai S, Okado H, Miyashita T, Saitoe M, Akiyama H, Masai H, Hasegawa M. (2016) Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43. J Biol Chem 291: 5473-5483
- Hasegawa M, Nonaka T, Masuda-Suzukake M. (2016) α-Synuclein: Experimental Pathology. Cold Spring Harb Perspect Med 6(9): a024273
- Tarutani A, Suzuki G, Shimozawa A, Nonaka T, Akiyama H, Hisanaga S, Hasegawa M. (2016) The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation. J Biol Chem 291(36):18675-88
- Tanaka Y, Hasegawa M. (2016) Profilin 1 mutants form aggregates that induce accumulation of prion-like TDP-43. Prion 10(4):283-9
- Oikawa T, Nonaka T, Terada M, Tamaoka A, Hisanaga S, Hasegawa M (2016) α-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly. J Biol Chem 291(29):15046-56
- Kawakami I, Kobayashi Z, Arai T, Yokota O, Nonaka T, Aoki N, Niizato K, Oshima K, Higashi S, Katsuse O, Hosokawa M, Hasegawa M, Akiyama H. (2016) Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration. Acta Neuropathol Commun 4:36
- Shimonaka S, Nonaka T, Suzuki G, Hisanaga S, Hasegawa M. (2016) Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils. J Biol Chem 291(17):8896-907
- Cacabelos D, Ayala V, Granado-Serrano AB, Jove M, Torres P, Boada J, Cabre R, Ramirez-Nunez O, Gonzalo H, Soler-Cantero A, Serrano JC, Bellmunt MJ, Romero MP, Motilva MJ, Nonaka T, Hasegawa M, Ferrer I, Pamplona R, Portero-Otin M. (2016) Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils. Neurobiol Dis 88:148-60
- Davidson Y, Robinson AC, Liu X, Wu D, Troakes C, Rollinson S, Masuda-Suzukake M, Suzuki G, Nonaka T, Shi J, Tian J, Hamdalla H, Ealing J, Richardson A, Jones M, Pickering-Brown S, Snowden JS, Hasegawa M, Mann DM. (2016) Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils. Neuropathol Appl Neurobiol 42(3):242-54
- Nagata E, Nonaka T, Moriya Y, Fujii N, Okada Y, Tsukamoto H, Itoh J, Okada C, Satoh T, Arai T, Hasegawa M, Takizawa S. (2016) Inositol Hexakisphosphate Kinase 2 Promotes Cell Death in Cells with Cytoplasmic TDP-43 Aggregation. Mol Neurobiol 53(8):5377-83
- Yoshinaga T, Yazaki M, Sekijima Y, Kametani F, Miyashita K, Hachiya N, Tanaka T, Kokudo N, Higuchi K, Ikeda S. (2016) The pathological and biochemical identification of possible seed-lesions of transmitted transthyretin amyloidosis after domino liver transplantation. J Pathol Clin Res 2(2):72-9
- Sekijima Y, Yazaki M, Oguchi K, Ezawa N, Yoshinaga T, Yamada M, Yahikozawa H, Watanabe M, Kametani F, Ikeda S. (2016) Cerebral amyloid angiopathy in posttransplant patients with hereditary ATTR amyloidosis. Neurology 87(8):773-81
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学会発表等
招待講演
- α-Synuclein Propagation in Parkinson’s Disease and Multiple System Atrophy.
- 長谷川成人 タンパク質の老化基盤と病原性タンパク質の伝播機構. 次世代脳プロジェクト, 冬のシンポジウム「脳タンパク質の老化と神経変性」, 東京 . [2016.12.19]
- 長谷川成人: 認知症疾患病原タンパク質の伝播. 第35回 日本認知症学会学術集会 プレナリーレクチャー, 東京 . [2016. 12. 1]
- 長谷川成人 プリオン現象で考える神経変性疾患. 新潟大学 大学院 医学研究科 特別講義, 新潟 . [2016.10.30]
- 長谷川成人 パーキンソン病、レビー小体型認知症の原因タンパク質: αシヌクレイン. 「東海パーキンソン病治療・症例検討会」名古屋 . [2016.10.14]
- 長谷川成人 どのようなαシヌクレインがプリオン様伝播のシードとなるか? 第2回Kyoto Neurology Forum. 京都. [2016.9.10]
- Hasegawa M: Molecular mechanisms of TDP-43 aggregation. Brain Protein Aging and Dementia Control International Workshop. Nagoya . [2016.9.9]
- 長谷川成人、富田泰輔: Session 4: Aβオリゴマーか、タウか、あるいは両方か?永久に続く問い. 2016 タウミーティング. 東京 . [2016.8.26]
- Tarutani A, Suzuki G, Shimozawa A, Nonaka T, Hisanaga S, Hasegawa M: Pathogenic α-synuclein species in prion-like seeded aggregation. 第39回 日本神経科学会大会. 横浜 . [2016.7.20]
- 長谷川成人 プリオン様伝播で考える神経変性疾患とその治療戦略. 第46回 日本神経精神薬理学会年会. 韓国ソウル . [2016.7.2]
- 長谷川成人 PSP/CBD脳に蓄積するタウの生化学解析 第57回日本神経学会学術大会 シンポジウム, 神戸. [2016. 5. 21]
- Hasegawa M: αSynuclein prions, Luncheon Seminar 4, PRION 2016, Tokyo. [2016. 5. 13]
- Hasegawa M: Tau / TDP-43 prions, Invited Lectures: Expansion of prion concept, PRION 2016, Tokyo . [2016. 5. 10]
- 長谷川成人: Molecular and Biochemical Analyses of Pathological Tau Proteins in Tauopathy Brains. 2016 アルツハイマー病分科会, 東京 . [2016.1.24]
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