Achievement
研究業績
2010年
論文発表
- Nonaka T, Watanabe ST, Iwatsubo T, Hasegawa M. (2010) Seeded aggregation and toxicity of alpha-synuclein and tau: cellular models of neurodegenerative diseases. J Biol Chem. 285(45):34885-98. doi: 10.1074/jbc.M110.148460.
- Yokota O, Davidson Y, Arai T, Hasegawa M, Akiyama H, Ishizu H, Terada S, Sikkink S, Pickering-Brown S, Mann DM. (2010) Effect of topographical distribution of alpha-synuclein pathology on TDP-43 accumulation in Lewy body disease. Acta Neuropathol. 120(6):789-801. doi: 10.1007/s00401-010-0731-9.
- Araki W, Kametani F, Oda A, Tamaoka A. (2010) MEK inhibitors suppress beta-amyloid production by altering the level of a beta-C-terminal fragment of amyloid precursor protein in neuronal cells. FEBS Lett. 584(15):3410-4. doi: 10.1016/j.febslet.2010.06.038.
- Asaoka T, Tsuchiya K, Fujishiro H, Arai T, Hasegawa M, Akiyama H, Iseki E, Oda T, Onaya M, Tominaga I. (2010) Argyrophilic grain disease with delusions and hallucinations: a pathological study. Psychogeriatrics. 10(2):69-76. doi: 10.1111/j.1479-8301.2010.00318.x.
- Yokota O, Davidson Y, Bigio EH, Ishizu H, Terada S, Arai T, Hasegawa M, Akiyama H, Sikkink S, Pickering-Brown S, Mann DM. (2010) Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy. Acta Neuropathol. 120(1):55-66. doi: 10.1007/s00401-010-0702-1.
- Nakamura A, Kawakami K, Kametani F, Nakamoto H, Goto S. (2010) Biological significance of protein modifications in aging and calorie restriction.Ann N Y Acad Sci. 1197:33-9. doi: 10.1111/j.1749-6632.2009.05374.x.
- Tamaoka A, Arai M, Itokawa M, Arai T, Hasegawa M, Tsuchiya K, Takuma H, Tsuji H, Ishii A, Watanabe M, Takahashi Y, Goto J, Tsuji S, Akiyama H. (2010) TDP-43 M337V mutation in familial amyotrophic lateral sclerosis in Japan. Intern Med. 49(4):331-4.
- Arai T, Hasegawa M, Nonoka T, Kametani F, Yamashita M, Hosokawa M, Niizato K, Tsuchiya K, Kobayashi Z, Ikeda K, Yoshida M, Onaya M, Fujishiro H, Akiyama H. (2010) Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy. Neuropathology. 30(2):170-81. doi: 10.1111/j.1440-1789.2009.01089.x.
- Yamaguchi Y, Masuda M, Sasakawa H, Nonaka T, Hanashima S, Hisanaga SI, Kato K, Hasegawa M. (2010) Characterization of inhibitor-bound alpha-synuclein dimer: role of alpha-synuclein N-terminal region in dimerization and inhibitor binding. J Mol Biol. 395(3):445-56. doi: 10.1016/j.jmb.2009.10.068.
- 長谷川成人. TDP-43とFTLD/ALS. 老年期認知症研究会誌 17, 105-108, 2010.
- 山下万貴子, 長谷川成人. シナプス病態, TDP-43 proteinopathy. Clinical Neurosci 28, 904-905, 2010.
- 長谷川成人、新井哲明. TDP-43蓄積症の発見 最新医学 65:1558-1565, 2010.
- 野中隆、長谷川成人.細胞内TDP-43蓄積のメカニズム 最新医学 65: 1572-1578, 2010.
- 山下万貴子、野中隆、長谷川成人.TDP-43凝集体形成阻害化合物の検索 最新医学 65: 1597-1602, 2010.
- 秋山治彦、新井哲明、長谷川成人.アルツハイマー病およびレビー小体型認知症におけるリン酸化TDP-43 最新医学 65: 1625-1631, 2010.
- 長谷川成人, 野中隆, 新井哲明, 秋山治彦. TDP-43 proteinopathy ?その広がりと病因的意義. Annual Review 神経 2010, 187-195.2010.
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学会発表等
招待講演
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長谷川成人:病理構造物の解析から導かれた精神神経疾患の新しい考え方; 細胞内異常タンパク質伝播仮説; [講演]. 第39回精神研シンポジウム「精神医学研究の到達点と展望」, 東京 . [2010.11.22]
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Hasegawa M:Therapeutic approaches targeting tau protein for neurodegenerative diseases. International Seminar Aging, Tau Protein and Dementias, French Embassy, Tokyo, Japan . [2010.10.20]
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Hasegawa M, Nonaka T, Tsuji H, Yamashita M, Kametani F, Tamaoka A, Arai T, Akiyama H : Molecular dissection of TDP-43 proteinopathies. The 7th International Conference on Frontotemporal Dementias, Indianapolis, USA. [2010.10.6]
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Hasegawa M, Arai T, Nonaka T, Kametani F, Yoshida M, Ikeda K, Akiyama H : Proteomic analyses of TDP-43 proteinopathy. Neuro2010 Joint Conference, The 33rd Annual Meeting of the Japan Neuroscience Society, Kobe,Japan . [2010.9.4]
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Masuda M, Taniguchi S, Suzuki N, Hasegawa M : Therapeutic approaches of targeting pathological tau protein for neurodegenerative diseases. Neuro2010 Joint Conference, The 33rd Annual Meeting of the Japan Neuroscience Society, Kobe,Japan . [2010.9.3]
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長谷川成人:ALSの分子病態解明と治療に向けて. 日本神経治療学会, シンポジウム2, 神経治療学のブレークスルー:神経疾患の新規治療, 横浜 . [2010.7.21]
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長谷川成人:TDP-43の発見から動物モデルまで. 第51回日本神経学会総会, シンポジウム13「筋萎縮性側索硬化症の病因TDP-43およびFUS/TLS研究の最前線」, 東京. [2010.5.22]
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長谷川成人:筋萎縮性側索硬化症、前頭側頭葉変性症を特徴づける封入体の構成タンパク質、TDP-43. 第99回日本病理学会総会, ワークショップ12「神経変性疾患と封入体」, 東京. [2010.4.29]
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長谷川成人:生化学的方法と神経病理. 第51回日本神経病理学会総会学術研究会, シンポジウム2[神経病理の更なる発展に向けて②], 東京. [2010.4.24]
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