Achievement
研究業績

2021年

• 論文発表
• 総説・著書
• 学会発表等
• その他

論文発表

• Samimi N, Sharma G, Kimura T, Matsubara T, Huo A, Chiba K, Saito Y, Murayama S, Akatsu H, Hashizume Y, Hasegawa M, Farjam M, Shahpasand K, Ando K, Hisanaga SI. Distinct phosphorylation profiles of tau in brains of patients with different tauopathies. Neurobiol Aging. 2021 Dec;108:72-79. doi: 10.1016/j.neurobiolaging.2021.08.011
• Kato T, Manabe RI, Igarashi H, Kametani F, Hirokawa S, Sekine Y, Fujita N, Saito S, Kawashima Y, Hatano Y, Ando S, Nozaki H, Sugai A, Uemura M, Fukunaga M, Sato T, Koyama A, Saito R, Sugie A, Toyoshima Y, Kawata H, Murayama S, Matsumoto M, Kakita A, Hasegawa M, Ihara M, Kanazawa M, Nishizawa M, Tsuji S, Onodera O. Candesartan prevents arteriopathy progression in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy model. J Clin Invest. 2021 Nov 15;131(22):e140555. doi: 10.1172/JCI140555.
• Shi Y, Zhang W, Yang Y, Murzin A, Falcon B, Kotecha A, van Beers M, Tarutani A, Kametani F, Garringer H, Vidal R, Hallinan G, Lashley T, Saito Y, Shigeo S, Yoshida M, Tanaka H, Kakita A, Ikeuchi T, Robinson A, Mann D, Kovacs G, Revesz T, Ghetti B, Hasegawa M, Goedert M, Scheres S, "Structure-based classification of tauopathies", Nature 2021 Oct;598(7880):359-363. doi: 10.1038/s41586-021-03911-7
• Hosokawa M, Masuda-Suzukake M, Shitara H, Shimozawa A, Suzuki G, Kondo H, Nonaka T, Campbell W, Arai T, Hasegawa M, Development of a novel tau propagation mouse model endogenously expressing 3 and 4 repeat tau isoforms. Brain 2021 Sep 13:awab289. doi: 10.1093/brain/awab289
• Tarutani A, Miyata H, Nonaka T, Hasegawa K, Yoshida M, Saito Y, Murayama S, Robinson AC, Mann DMA, Tomita T, Hasegawa M. Human tauopathy-derived tau strains determine the substrates recruited for templated amplification. Brain. 2021 Sep 4;144(8):2333-2348. doi: 10.1093/brain/awab091
• Mitani TT, Beck G, Kido K, Yamashita R, Yonenobu Y, Ogawa T, Saeki C, Okuno T, Nagano S, Morii E, Hasegawa M, Saito Y, Murayama S, Mochizuki H. Amyotrophic lateral sclerosis with speech apraxia, predominant upper motor neuron signs, and prominent iron accumulation in the frontal operculum and precentral gyrus. Neuropathology. 2021 Aug;. doi: 10.1111/neup.12763.
• Ando T, Yokoi F, Riku Y, Akagi A, Miyahara H, Hasegawa M, Katsuno M, Yoshida M, Iwasaki Y. The hot cross bun sign in corticobasal degeneration. Neuropathology. 2021 Jul 28. doi: 10.1111/neup.12745.
• Dilsizoglu Senol A, Samarani M, Syan S, Guardia CM, Nonaka T, Liv N, Latour-Lambert P, Hasegawa M, Klumperman J, Bonifacino JS, Zurzolo C. α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes, PLoS Biol. 2021 Jul 20;19(7):e3001287. doi: 10.1371/journal.pbio.3001287.
• Nihonmatsu-Kikuchi N, Yu X , Matsuda Y, Ozawa N, Ito T, Satou K, Kaname T, Iwasaki Y, Akagi A, Yoshida M , Toru S, Hirokawa K, Takashima A, Hasegawa M, Uchihara T, Tatebayashi Y. Essential roles of plexin-B3+ oligodendrocyte precursor cells in the pathogenesis of Alzheimer’s disease, Commun Biol. 2021 Jul 15;4(1):870. doi: 10.1038/s42003-021-02404-7.
• Watanabe R, Kawakami I, Ikeuchi T, Murayama S, Arai T, Akiyama H, Onaya M, Hasegawa M. An autopsied FTDP-17 case with MAPT IVS 10 + 14C > T mutation presenting with frontotemporal dementia. eNeurol Sci 2021 Jul; 100363. doi: 10.1016/j.ensci.2021.100363
• Ishida C, Kato-Motozaki Y, Noto D, Nomai K, Hasegawa M, Ikeuchi T, Yamada M. An autopsy case of corticobasal degeneration with inferior olivary hypertrophy. Neuropathology 2021 Jun;41(3):226-235. doi: 10.1111/neup.12725.
• Tando S, Kasai T, Mizuta I, Takahashi H, Yaoi T, Saito K, Honjo T, Mizuno T, Hasegawa M, Itoh K. An autopsy case of corticobasal syndrome due to asymmetric degeneration of the motor cortex and substantia nigra with TDP-43 proteinopathy, associated with Alzheimer's disease pathology. Neuropathology 2021 Jun;41(3):214-225. doi: 10.1111/neup.12723
• Lövestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW. Seeded assembly in vitro does not replicate the structures of α-synuclein filaments from multiple system atrophy. FEBS Open Bio 2021 Apr;11(4):999-1013. doi: 10.1002/2211-5463.13110
• Kawakami I, Motoda A, Hashimoto M, Shimozawa A, Masuda-Suzukake M, Ohtani R, Takase M, Kumashiro M, Samejima K, Hasegawa M. Progression of phosphorylated alpha-synuclein in Macaca fuscata. Brain Pathol. 2021 Mar 22:e12952. doi: 10.1111/bpa.1295

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総説・著書

英文

• Goedert M, Spillantini MG, Falcon B, Zhang W, Newell KL, Hasegawa M, Scheres SHW, Ghetti B. Tau Protein and Frontotemporal Dementias. Adv Exp Med Biol. 2021;1281:177-199. doi: 10.1007/978-3-030-51140-1_12.
• Masuda-Suzukake M, Shimozawa A, Hashimoto M, Hasegawa M. Common Marmoset Model of alpha-Synuclein Propagation. Methods Mol Biol. 2021;2322:131-139. doi: 10.1007/978-1-0716-1495-2_13.
• Tarutani A, Hasegawa M. Electron Microscopic Analysis of α-Synuclein Fibrils. Methods Mol Biol. 2021;2322:17-25. doi: 10.1007/978-1-0716-1495-2_2.

和文

• 長谷川成人. タウ介入による認知症治療. 老年内科 3(6): 731-738. 2021年.

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学会発表等

招待講演

• Hasegawa M. Prion-like propagation of α-synuclein and tau in neurodegenerative diseases. 2021 INTERNATIONAL CHEMICAL CONGRESS OF PACIFIC BASIN SOCIETIE. (Hawaii, Hybrid). [2021.12.19]
• Hasegawa M. Prion-like propagation of pathological tau in neurodegenerative diseases. 14th Meeting of the Asia Pacific Federation of Pharmacologists. (Taipei, Hybrid). [2021.11.28]
• 長谷川成人. タウ、αシヌクレインのプリオン様伝播. 第40回 日本認知症学会学術集会シンポジウム「Propagation 2021」. 東京. [2021.11.28]
• 長谷川成人. タウ病変を伴う認知症疾患の生化学構造分類. 第40回日本認知症学会 学術集会 ランチョンセミナー6. 東京. [2021.11.27]
• 長谷川成人. タウの病態と認知症治療戦略. 日本脳神経外科学会第80回学術総会. 横浜. [2021.10.29]
• Hasegawa M. Molecular dissection of pathological TDP-43. PACTALS 2021 NAGOYA. （オンライン開催）. [2021.9.17]
• 長谷川成人. パーキンソン病と認知症, 第123回 宮崎神経内科懇話会, （オンライン開催）. [2021.6.30]
• 長谷川成人. α-シヌクレインの分子病理について, 第9回パーキンソン病と神経科学研究会, （オンライン開催）. [2021.6.18]
• 長谷川成人. 神経変性の原因となる細胞内アミロイド様タンパク質, 第62回 日本神経病理学会総会 学術研究会 神経病理学会・神経化学会共催シンポジウム. （東京・オンライン開催）. [2021.5.27]
• Hasegawa M. "Structure and propagation of α-synuclein and tau", 62nd Annual Meeting of the Japanese Society of Neurology. Neuroscience Frontier Symposium, (Kyoto, Hybrid)[2021.5.21]
• 長谷川成人. 神経変性の原因となる異常型タンパク質の形成機構, 長谷川成人, 同志社大学 脳科学研究科セミナー. （オンライン開催）. [2021.3.17]
• Hasegawa M: Neurobiology of synucleinopathies, The 7th International Conference on Multiple System Atrophy. [2021.2.27]
• 長谷川成人.タウ、α-シヌクレイン、TDP43 凝集体が形成される神経変性疾患の病態研究, 長谷川成人, 量子イメージング創薬アライアンス・脳とこころ （オンライン開催）. [2021.2.25]

その他

広報

• 2021年度 第6回 都医学研 都民講座 「レビー小体型認知症をめぐる最近の動向」司会

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