Achievement
研究業績
2022年
論文発表
- Nelson PT, Lee EB, Cykowski MD, Alafuzoff I, Arfanakis K, Attems J, Brayne C, Corrada MM, Dugger BN, Flanagan ME, Ghetti B, Grinberg LT, Grossman M, Grothe MJ, Halliday GM, Hasegawa M, Hokkanen SRK, Hunter S, Jellinger K, Kawas CH, Keene CD, Kouri N, Kovacs GG, Leverenz JB, Latimer CS, Mackenzie IR, Mao Q, McAleese KE, Merrick R, Montine TJ, Murray ME, Myllykangas L, Nag S, Neltner JH, Newell KL, Rissman RA, Saito Y, Sajjadi SA, Schwetye KE, Teich AF, Thal DR, Tomé SO, Troncoso JC, Wang SJ, White CL 3rd, Wisniewski T, Yang HS, Schneider JA, Dickson DW, Neumann M. LATE-NC staging in routine neuropathologic diagnosis: an update. Acta Neuropathol. 2022 Dec 13. doi: 10.1007/s00401-022-02524-2.
- Kaide S, Watanabe H, Iikuni S, Hasegawa M, Ono M. Synthesis and Evaluation of 18F-Labeled Chalcone Analogue for Detection of α-Synuclein Aggregates in the Brain Using the Mouse Model. ACS Chem Neurosci. 2022 Oct;42(5):447-452. doi: 10.1021/acschemneuro.2c00473.
- Suzuki Y, Adachi T, Sakuwa M, Sakata R, Takigawa H, Hasegawa M, Hanajima R. An autopsy case of progressive supranuclear palsy. Pallido-nigro-luysian type with argyrophilic grains clinically presenting with personality and behavioral changes. Neuropathology. 2022 Oct;42(5):447-452. doi: 10.1111/neup.12815.
- Yang Y, Shi Y, Schweighauser M, Zhang X, Kotecha A, Murzin AG, Garringer HJ, Cullinane PW, Saito Y, Foroud T, Warner TT, Hasegawa K, Vidal R, Murayama S, Revesz T, Ghetti B, Hasegawa M, Lashley T, Scheres SHW, Goedert M. Structures of α-synuclein filaments from human brains with Lewy pathology. Nature. 2022 Oct;610(7933):791-795. doi: 10.1038/s41586-022-05319-3.
- Saitoh Y, Imabayashi E, Mizutani M, Tsukamoto T, Hasegawa M, Saito Y, Matsuda H, Takahashi Y. 18F-THK5351 PET for visualizing predominant lesions of pathologically confirmed corticobasal degeneration presenting with frontal behavioral-spatial syndrome. J Neurol. 2022 Sep;269(9):5157-5161. doi: 10.1007/s00415-022-11121-y.
- Yamashita R, Beck G, Yonenobu Y, Inoue K, Mitsutake A, Ishiura H, Hasegawa M, Murayama S, Mochizuki H. TDP-43 Proteinopathy Presenting with Typical Symptoms of Parkinson's Disease. Mov Disord. 2022 Jul;37(7):1561-1563. doi: 10.1002/mds.29048.
- Kishino Y, Matsukawa K, Matsumoto T, Miyazaki R, Wakabayashi T, Nonaka T, Kametani F, Hasegawa M, Hashimoto T, Iwatsubo T. Casein kinase 1δ/ε phosphorylates fused in sarcoma (FUS) and ameliorates FUS-mediated neurodegeneration. J Biol Chem. 2022 Jun 23:102191. doi: 10.1016/j.jbc.2022.102191.
- Shimizu A, Akagi A, Ishida C, Sakai K, Komai K, Kawamura M, Hasegawa M, Ikeuchi T, Yamada M. Frontotemporal Lobar Degeneration With Unclassifiable 4-Repeat Tauopathy Mimicking Globular Glial Tauopathy. J Neuropathol Exp Neurol. 2022 Jun 20;81(7):581-584. doi: 10.1093/jnen/nlac039.
- Tarutani A, Adachi T, Akatsu H, Hashizume Y, Hasegawa K, Saito Y, Robinson AC, Mann DMA, Yoshida M, Murayama S, Hasegawa M. Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43. Acta Neuropathol. 2022 Jun;143(6):613-640. doi: 10.1007/s00401-022-02426-3.
- Matsuo K, Goto D, Hasegawa M, Ogita K, Koyama T, Akagi A, Kitamoto T, Yoshida M, Iwasaki Y. An autopsy case of MV2K-type sporadic Creutzfeldt-Jakob disease presenting with characteristic clinical, radiological, and neuropathological findings. Neuropathology. 2022 Jun;42(3):245-253.
- Kametani F, Hasegawa M. Structures of tau and α-synuclein filaments from brains of patients with neurodegenerative diseases. Neurochem Int. 2022 May 31;158:105362. doi: 10.1016/j.neuint.2022.105362.
- Akasaka T, Watanabe H, Kaide S, Iikuni S, Hasegawa M, Ono M. Synthesis and evaluation of novel radioiodinated phenylbenzofuranone derivatives as α-synuclein imaging probes. Bioorg Med Chem Lett. 2022 May 15;64:128679. doi: 10.1016/j.bmcl.2022.128679.
- Schweighauser M, Arseni D, Bacioglu M, Huang M, Lövestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW. Age-dependent formation of TMEM106B amyloid filaments in human brains. Nature. 2022 May, 605(7909):310-3148. doi: 10.1038/s41586-022-04650-z.
- Matsuo K, Goto D, Hasegawa M, Ogita K, Koyama T, Akagi A, Kitamoto T, Yoshida M, Iwasaki Y. An autopsy case of MV2K-type sporadic Creutzfeldt-Jakob disease presenting with characteristic clinical, radiological, and neuropathological findings. Neuropathology. 2022 Apr 19. doi: 10.1111/neup.12804.
- Saitoh Y, Iwasaki M, Mizutani M, Kimura Y, Hasegawa M, Sato N, Takao M, Takahashi Y. Pathologically Verified Corticobasal Degeneration Mimicking Richardson's Syndrome Coexisting with Clinically and Radiologically Shunt-Responsive Normal Pressure Hydrocephalus. Mov Disord Clin Pract. 2022 Apr 12;9(4):508-515. doi: 10.1002/mdc3.13442.
- Miyahara H, Akagi A, Riku Y, Sone J, Otsuka Y, Sakai M, Kuru S, Hasegawa M, Yoshida M, Kakita A, Iwasaki Y. Independent distribution between tauopathy secondary to subacute sclerotic panencephalitis and measles virus: An immunohistochemical analysis in autopsy cases including cases treated with aggressive antiviral therapies. Brain Pathol. 2022 Apr 4:e13069. doi: 10.1111/bpa.13069.
- Riku Y, Iwasaki Y, Ishigaki S, Akagi A, Hasegawa M, Nishioka K, Li Y, Riku M, Ikeuchi T, Fujioka Y, Miyahara H, Sone J, Hattori N, Yoshida M, Katsuno M, Sobue G. Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration. Brain. 2022 Mar 11:awac091. doi: 10.1093/brain/awac091.
- Kawakami I, Iritani S, Riku R, Umeda K, Takase T, Ikeda K, Niizato N, Arai T, Yoshida M, Oshima K and Hasegawa M. Neuropathological investigation of patients with prolonged anorexia nervosa. Psychiat and Clin Neurosci 2022 May;76(5):187-194. doi: 10.1111/pcn.13340. Epub 2022 Mar 7.
- Nicolas G, Sévigny M, Lecoquierre F, Marguet F, Deschênes A, Del Pelaez MC, Feuillette S, Audebrand A, Lecourtois M, Rousseau S, Richard AC, Cassinari K, Deramecourt V, Duyckaerts C, Boland A, Deleuze JF, Meyer V, Clarimon Echavarria J, Gelpi E, Akiyama H, Hasegawa M, Kawakami I, Wong TH, Van Rooij JGJ, Van Swieten JC, Campion D, Dutchak PA, Wallon D, Lavoie-Cardinal F, Laquerrière A, Rovelet-Lecrux A, Sephton CF. A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics. Acta Neuropathol Commun. 2022 Feb 12;10(1):20. doi: 10.1186/s40478-022-01314-x
- Beck G, Shigenobu K, Ukon K, Yamashita R, Yonenobu Y, Morii E, Hasegawa M, Ikeda M, Murayama S, Mochizuki H. An autopsy case of Alzheimer's disease with amygdala-predominant Lewy pathology presenting with frontotemporal dementia-like psychiatric symptoms, Neuropathology. 2022 Feb 2. doi: 10.1111/neup.12786.
- Kokubo Y, Morimoto S, Sasaki R, Hasegawa M, Ishiura H, Tsuji S, Yoshida M, Yamazoe N, Miyazaki M, Kuzuhara S. An immigrant family with Kii amyotrophic lateral sclerosis/parkinsonism-dementia complex. Neurol Sci. 2022 Feb;43(2):1423-1425. doi: 10.1007/s10072-021-05737-7.
- Awa S, Suzuki G, Masuda-Suzukake M, Nonaka T, Saito M, Hasegawa M. Phosphorylation of endogenous alpha-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body. Sci Rep. 2022 Jan 21;12(1):1163. doi: 10.1038/s41598-022-04780-4.
- Komaki K, Takano T, Sato Y, Asada A, Ikeda S, Yamada K, Wei R, Huo A, Fukuchi A, Saito T, Ando K, Murayama S, Araki W, Kametani F, Hasegawa M, Iwatsubo T, Tomomura M, Fukuda M, Hisanaga SI. Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of β-secretase BACE1. J Biochem. 2022 Jan 7;170(6):729-738. Doi: 10.1093/jb/mvab094.
- Kaide S, Watanabe H, Iikuni S, Hasegawa M, Itoh K, Ono M. Chalcone Analogue as New Candidate for Selective Detection of alpha-Synuclein Pathology. ACS Chem Neurosci. 2022 Jan 5;13(1):16-26. doi: 10.1021/acschemneuro.1c00441.
- Arseni D, Hasegawa M, Murzin AG, Kametani F, Arai M, Yoshida M, Falcon B, Structures of TDP-43 filaments from amyotrophic 1 lateral sclerosis with frontotemporal lobar degeneration, Nature 2022 Jan;601(7891):139-143. doi: 10.1038/s41586-021-04199-3.
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総説・著書
和文
- 長谷川成人. クライオ電顕が解き明かす神経変性疾患のメカニズム. 企画、編集、巻頭のことば. 医学のあゆみ 283(13): 2022年12月.
- 樽谷愛理、長谷川成人. タウ線維構造に基づいたタウオパチーの疾患分類. 医学のあゆみ 283(13): 2022年12月.
- 長谷川成人. ALS患者脳に蓄積するTDP-43線維の構造. 医学のあゆみ 283(13): 2022年12月.
- 樽谷愛理、長谷川成人. 異常型タウの構造多型は多様なタウオパチー病理の形成に寄与する Brain & Nerve 74 (7), 919-925, 2022.
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学会発表等
招待講演
- 長谷川成人. ALS患者脳に蓄積するTDP-43線維の構造解析. 第6回 せりか基金 受賞式. 東京 (ハイブリッド開催). [2022.12.16]
- 長谷川成人. タウ、αシヌクレイン、TDP-43凝集体の立体構造. 第41回日本認知症学会学術集会 第37回日本老年精神医学会 合同開催. 東京. [2022.11.28]
- 長谷川成人. Prion-like propagation of pathological αsynuclein in PD and related disorders. Novartis Symposium on PD and Related Neurological Disorders (NSPD) 2022. Tokyo. [2022.11.20]
- 長谷川成人. 筋萎縮性側索硬化症 (ALS) および前頭側頭葉変性症 (FTLD) の病理学的特徴である TDP-43 の同定、および神経変性疾患の研究. クラリベイト引用栄誉賞(Citation Laureate) 2022記者会見. [2022.9.21]
- 長谷川成人. 神経変性疾患における異常タンパク質の病変形成機構. Global NeuroCPC. (オンライン開催). [2022.9.12]
- Hasegawa M. Molecular mechanisms of formation and propagation of pathological proteins in neurodegenerative diseases. The 2022 Tokizane Memorial Award. NEURO2022. (Okinawa, Hybrid). [2022.7.1]
- 長谷川成人. 神経変性疾患における異常タンパク質の伝播機構. 第63回 日本神経病理学会総会学術研究会. 京都. [2022.6.25]
- 長谷川成人. 認知症患者脳に蓄積する病的タンパク質の生化学. 構造解析 文部科学省 科学研究費 学術変革領域研究 『学術研究支援基盤形成』生命科学4プラットフォーム「支援説明会・キックオフシンポジウム」. 弥生講堂一条ホール. [2022.6.3]
- Hasegawa M. Biochemical distinction CBD/PSP. 63rd Annual Meeting of the Japanese Society of Neurology. (Tokyo, Hybrid). [2022.5.18]
- 長谷川成人. αシヌクレインの構造とSpreading. 第12回日本小脳学会学術集会・総会. (オンライン開催). [2022.3.11]
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