Achievement
研究業績
2020年
論文発表
原著論文
- Kaide S, Watanabe H, Shimizu Y, Iikuni S, Nakamoto Y, Hasegawa M, Itoh K Ono M. Identification and Evaluation of Bisquinoline Scaffold as New Candidate for α-Synuclein-PET Imaging. ACS Chem Neurosci in press.
- Tanei ZI, Saito Y, Ito S, Matsubara T, Motoda A, Yamazaki M, Sakashita Y, Kawakami I, Ikemura M, Tanaka S, Sengoku R, Arai T, Murayama S. Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases. Acta Neuropathol. 2020 Nov 5. doi: 10.1007/s00401-020-02233-8.
- Kametani F, Yoshida M, Matsubara T, Murayama S, Saito Y, Kawakami I, Onaya M, Tanaka H, Kakita A, Robinson A, Mann M, Hasegawa M. Comparison of common and disease-specific post-translational modifications of pathological tau associated with a wide range of tauopathies. Front Neurosci 2020 Nov 4; 581936. doi: 10.3389/fnins.2020.581936.
- Watanabe R, Higashi S, Nonaka T, Kawakami I, Oshima K, Niizato K, Akiyama H, Yoshida M, Hasegawa M, Arai T. Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions. Acta Neuropathol Commun 2020 Oct 28;8(1):176. doi: 10.1186/s40478-020-01055-9.
- Abe R, Katoh N, Takahashi Y, Takasone K, Yoshinaga T, Yazaki M, Kametani F, Sekijima Y. Distribution of amyloidosis subtypes based on tissue biopsy site - Consecutive analysis of 729 patients at a single amyloidosis center in Japan. Pathol Int. 2020, Oct 28. doi: 10.1111/pin.13041.
- Shimonaka S, Matsumoto SE, Elahi M, Ishiguro K, Hasegawa M, Hattori N, Motoi Y. Asparagine residue 368 is involved in Alzheimer's disease tau strain-specific aggregation. J Biol Chem 2020 Oct 9;295(41):13996-14014.doi: 10.1074/jbc.RA120.013271.
- Aono Y, Hamatani Y, Katoh N, Nakagawa M, Nakamura K, Yazaki M, Kametani F, Iguchi M, Murakami I, Ogawa H, Abe M, Akao M, Sekijima Y. A Case of Late-onset Hereditary ATTR Amyloidosis with a Novel p.P63S (P43S) Transthyretin Variant. Intern Med. 2020, Sep 30. doi: 10.2169/internalmedicine.5615-20.
- Schweighauser M, Shi Y, Tarutani A, Kametani F, Murzin AG, Ghetti B, Matsubara T, Tomita T, Ando T, Hasegawa K, Murayama S, Yoshida M, Hasegawa M, Scheres SHW, Goedert M. Structures of α-synuclein filaments from multiple system atrophy. Nature 2020 Sep; 585(7825):464-469. doi: 10.1038/s41586-020-2317-6.
- Nakano M, Riku Y, Nishioka K, Hasegawa M, Washimi Y, Arahata Y, Takeda A, Horibe K, Yamaoka A, Suzuki K, Tsujimoto M, Li Y, Yoshino H, Hattori N, Akagi A, Miyahara H, Iwasaki Y, Yoshida M. Unclassified four-repeat tauopathy associated with familial parkinsonism and progressive respiratory failure. Acta Neuropathol Commun 2020 Aug 27;8(1):148. doi: 10.1186/s40478-020-01025-1.
- Suzuki G, Imura S, Hosokawa M, Katsumata R, Nonaka T, Shin-Ichi Hisanaga SI, Saeki Y, Hasegawa M. α-Synuclein strains that cause distinct pathologies differentially inhibit proteasome. ELife. 2020 Jul 22;9:e56825. doi: 10.7554/eLife.56825.
- Hirano M, Iritani S, Fujishiro H, Torii Y, Kawashima K, Sekiguchi H, Habuchi C, Yamada K, Ikeda T, Hasegawa M, Ikeuchi T, Yoshida M and Ozaki N. Globular glial tauopathy Type I presenting with behavioral variant frontotemporal dementia. Neuropathol 2020 July 21. doi.org/10.1111/neup.12668.
- Sasaki T, Shimazawa M, Kanamori H, Yamada Y, Nishinaka A, Kuse Y, Suzuki G, Masuda T, Nakamura S, Hosokawa M, Minatoguchi S, Hara H. Effects of progranulin on the pathological conditions in experimental myocardial infarction model. Sci Rep 2020 Jul 16;10(1):11842. doi: 10.1038/s41598-020-68804-7.
- Ichimata S, Hata Y, Abe R, Yoshinaga T, Katoh N, Kametani F, Yazaki M, Sekijima Y, Ehara T, Nishida N. An autopsy case of amyloid tubulopathy exhibiting characteristic spheroid-type deposition. Virchows Arch. 2020 Jul;477(1):157-163. doi: 10.1007/s00428-019-02740-4.
- Arakawa A, Saito Y, Seki T, Mitsutake A, Sato T, Katsumata J, Maekawa R, Hideyama T, Tamura K, Hasegawa M, Shiio Y. Corticobasal degeneration with deep white matter lesion diagnosed by brain biopsy. Neuropathol 2020 Jun;40(3):287-294. doi: 10.1111/neup.12638.
- Morgan SA, Lavenir I, Fan J, Masuda-Suzukake M, Passarella D, DeTure MA, Dickson DW, Ghetti B, Goedert M. α-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are major seed-competent species. J Biol Chem 2020 May 8; 295(19):6652-6664. doi: 10.1074/jbc.RA119.012179
- Miki T, Yokota O, Haraguchi T, Ishizu H, Hasegawa M, Ishihara T, Ueno SI, Takenoshita S, Terada S, Yamada N. Factors associated with development and distribution of granular/fuzzy astrocytes in neurodegenerative diseases. Brain Pathol 2020 Apr 15. doi: 10.1111/bpa.12843.
- Zhang W, Tarutani A, Newell K, Murzin A, Matsubara T, Falcon B, Vidal R, Garringer H, Shi Y, Ikeuchi T, Murayama S, Ghetti B, Hasegawa M, Goedert M, Scheres SHW. Novel tau filament fold in corticobasal degeneration. Nature 2020 Apr; 580(7802):283-287. doi: 10.1038/s41586-020-2043-0.
- Zhang W, Tarutani A, Newell KL, Murzin A, Matsubara T, Falcon B, Vidal R, Garringer HJ, Ikeuchi T, Murayama S, Ghetti B, Hasegawa M, Goedert M, Scheres SHW. Novel tau filament fold in corticobasal degeneration. Nature 2020 Feb 12. [Epub ahead of print]
- Arakawa A, Saito Y, Seki T, Mitsutake A, Sato T, Katsumata J, Maekawa R, Hideyama T, Tamura K, Hasegawa M, Shiio Y. Corticobasal degeneration with deep white matter lesion diagnosed by brain biopsy. Neuropathology. 2020 Jan 10. doi: 10.1111/neup.12638.
総説論文
- 木村妙子, 久永眞市, 長谷川成人. タウオパチー神経変性疾患と脳内炎症 BIO Clinica 25, 2020.11月
- Hasegawa M. Experimental models of prion-like protein propagation. Neuropathol 2020 Jun 1. doi: 10.1111/neup.12656.
- Motoi Y, Hanger DP, Hasegawa M. Editorial: Tau Propagation Mechanisms: Cell Models, Animal Models, and Beyond. Front Neurosci. 2020 May 19;14:456. doi: 10.3389/fnins.2020.00456.
- Nonaka T, Hasegawa M. Prion-like properties of assembled TDP-43. Curr Opin Neurobiol. 2020 Apr;61:23-28. doi: 10.1016/j.conb.2019.11.018.
- 鈴掛雅美、長谷川成人. αシヌクレインのプリオン様伝播仮説. Clinical Neuroscience. 2020.38: 827-9.
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総説・著書
著書
- Masuda-Suzukake M, Shimozawa A, Hashimoto M, Hasegawa M. Common marmoset model of alpha-synuclein propagation. Experimental Models of Parkinson’s Disease, Springer Nature, Submitted.
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学会発表等
国際学会：ポスター
- Murakami T, Kaku T, Kubo R, Tsukakoshi K, Ikebukuro K, Sassa Y, Kametani F. What is the amyloid protein in canine mammary tumor-associated amyloidosis? XVII International Symposium on Amyloidosis, PW112, Barcelona, Spain. [2020.9.14-18]
- Nakagawa M, Yazaki M, Higuchi K, Katoh N, Sekijima Y, Kametani F. Development of diagnositic antibodies against the heavy chain variable region for AH amyloidosis. XVII International Symposium on Amyloidosis, PW113, 14-18th Sep 2020, Barcelona, Spain
- Yoshinaga T, Yoshioka Y, Jager M, Peng H, Cheng M, Nelson L, Donnelly J, Ishikawa E, Kametani F, Sekijima Y, Kelly J. A case report of hereditary transthyretin amyloidosis in the novel variant transthyretin V121A(P.V141A). XVII International Symposium on Amyloidosis, PM120, Barcelona, Spain.[2020.9.14-18]
国内学会：講演
- 長谷川成人. タウの病態に介入する認知症治療戦略, 第39回日本認知症学会学術集会 プレナリーレクチャー2, 名古屋. [2020.11.26]
- 野中隆, シンポジウム３：細胞炎症を見る、制御する〜グリアテクノロジー. 第39回日本認知症学会学術集会. 座長. [2020.11.26]
- 細川雅人、長谷川成人 タウのプリオン様伝播の病態－モデルマウスの解析から 第39回日本認知症学会（名古屋・オンライン開催）[2020.11]
- 細川雅人、長谷川成人 タウのプリオン様伝播モデルマウス 第116回日本精神神経学会 （金沢・オンライン開催）. [2020.10]
- 細川雅人、長谷川成人 タウオパチーとタウ伝播のマウスモデル 第92回日本生化学会（横浜・オンライン開催）. [2020.9]
- 野中隆, プロテイノパチーの本態は何か？細胞内タンパク質凝集体のプリオン様性質. 第61回日本神経学会学術大会：ホットトピックス6. 座長および演者. [2020.8.31]
国内学会：ポスター
- 田中智子、平井志伸、細川雅人、斉藤貴志、佐久間啓、西道隆臣、長谷川成人、岡戸晴生 加齢性脳機能障害における発達期要因の解明 第39回日本認知症学会（名古屋・オンライン開催）. [2020.11]
- 亀谷富由樹, 松原知康, 安藤孝志, 長谷川一子, 村山繁雄, 吉田真理, 長谷川成人. 多系統萎縮症患者脳内に蓄積したαシヌクレインの翻訳後修飾の解析. 第39回日本認知症学会P307, 名古屋. [2020.11. 26-28]
- 田中良法, 亀谷富由樹, 竹谷浩介, 長谷川成人, 江藤真澄. PGK1によるリソソームを通じたTDP-43凝集抑制作用. 第39回日本認知症学会P308, 名古屋. [2020.11. 26-28]
その他
-
EurekAlertへの論文プレスリリース. [2020.9.23]
講義
- 野中隆 医療薬学特論. 東京大学大学院薬学系研究科. [2020.10.16]
- 野中隆 生命科学特別講義. 東京都立大学大学院. 南大沢. [2020.8.28]
- 細川雅人 徳島大学医学部講義 3年生 病理学 神経変性疾患3. [2020.5]
特許
-
METHOD OF PRODUCING A NOVEL DISEASE MODEL ANIMAL FOR TAUOPATHIES Masato Hosokawa, Hiroshi Shitara, Masato Hasegawa米国特許出願 16/805203. [2020.2]
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