Achievement
研究業績
2018年
論文発表
- Franco R, Andrésn DA, Canela EI, Lillo J, Tarutani A, Hasegawa M, Del Rio JA, Kreutz MR, Saura C, Navarro D. N-methyl-D-aspartate receptor link to the MAP kinase pathway in cortical and hippocampal neurons and microglia is dependent on calcium sensors and is blocked by α-synuclein, Tau and phospho-Tau in non-transgenic and transgenic APPSw, Ind mice. Front Mol Neurosci. 2018 Aug 28;11:273. doi: 10.3389/fnmol.2018.00273.
- Nonaka T, Masuda-Suzukake M, Hosokawa M, Shimozawa A, Hirai S, Okado, H., Hasegawa M. C9ORF72 dipeptide repeat poly-GA inclusions promote: intracellular aggregation of phosphorylated TDP-43. Hum Mol Genet, 2018 May 10. doi: 10.1093/hmg/ddy174.
- Terada T, Suzuki G, Nonaka T, Kametani F, Tamaoka A, and Hasegawa M*. The effect of truncation on prion-like properties of α-synuclein. J Biol Chem 293:13910-13920, 2018. doi: 10.1074/jbc.RA118.001862.
- Hasegawa I, Takeda A, Hatsuta H, Kubo Y, Ohsawa M, Nakano Y, Ikeuchi T, Hasegawa M, Murayama S, Itoh Y. An autopsy case of globular glial tauopathy presenting with clinical features of motor neuron disease with dementia and iron deposition in the motor cortex. Neuropathology in press.
- Watanabe R, Kawakami I, Onaya M, Higashi S, Arai N, Akiyama H, Hasegawa M, Arai T. Frontotemporal dementia with trans-activation response DNA-binding protein 43 presenting with catatonic syndrome. Neuropathology 38(3): 281-287, 2018.
- Uchino A, Ogino M, Takahashi-Fujigasaki J, Oonuma S, Kanazawa N, Kajita S, Ichinoe M, Hasegawa M, Nishiyama K, Murayama S. Pathological and immunoblot analysis of phosphorylated TDP-43 in sporadic amyotrophic lateral sclerosis with pallido-nigro-luysian degeneration. Neuropathology 38(2): 171-178, 2018.
- Tuerde D, Kimura T, Miyasaka T, Furusawa K, Shimozawa A, Hasegawa M, Ando K, Hisanaga SI. Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development. J Biol Chem 293(5): 1781-1793, 2018.
- Kaji S, Maki T, Kinoshita H, Uemura N, Ayaki T, Kawamoto Y, Furuta T, Urushitani M, Hasegawa M, Kinoshita Y, Ono Y, Mao X, Quach TH, Iwai K, Dawson VL, Dawson TM, Takahashi R. Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy. Stem Cell Rep. 10(2): 356-365, 2018.
- Yabe I, Yaguchi H, Kato Y, Miki Y, Takahashi H, Tanikawa S, Shirai S, Takahashi I, Kimura M, Hama Y, Matsushima M, Fujioka S, Kano T, Watanabe M, Nakagawa S, Kunieda Y, Ikeda Y, Hasegawa M, Nishihara H, Ohtsuka T, Tanaka S, Tsuboi Y, Hatakeyama S, Wakabayashi K, Sasaki H. Mutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy-like syndrome. Sci Rep 8(1): 819, 2018.
- Tarutani, A, Arai T Murayama, S., Hisanaga, S.I., Hasegawa, M*. Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods. Acta Neuropathol Commun 6: 29, 2018.
- Morimoto S, Hatsuta H, Kokubo Y, Nakano Y, Hasegawa M, Yoneda M, Hirokawa Y, Kuzuhara S, Shiraishi T, Murayama S. Unusual tau pathology of the cerebellum in patients with amyotrophic lateral sclerosis/parkinsonism-dementia complex from the kii peninsula, Japan. Brain Pathol 28: 287-291, 2018.
- Hosokawa M, Tanaka Y, Arai T, Kondo H, Akiyama H, Hasegawa M. Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer's disease model mice. Exp Anim 67: 63-70, 2018.
- Urrea L, Segura-Feliu M, Masuda-Suzukake M, Hervera A, Pedraz L, Aznar J, Vila M, Samitier J, Torrents E, Ferrer I, Gavín R, Hasegawa M, José Antonio del Río. Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons. Mol Neurobiol 55: 1861, 2018.
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学会発表等
招待講演
- 長谷川成人: 認知症疾患におけるタウの異常と伝播. 第91回日本生化学会大会 シンポジウム「脳タンパク質老化と神経変性. [2018. 9.25]
- Hasegawa M: Prion-like propagation of pathological tau in neurodegenerative diseases. ICN2018 Symposium 12, Protein Propagation in Neurodegeneration, Tokyo. [2018. 9.24]
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長谷川成人: 異常型タウの伝播で考えるアルツハイマー病, 千里ライフサイエンスセミナー. [2018. 9. 19]
- 長谷川成人: タウ病変の伝播を再現するマウスモデル. 第6回日本アミロイドーシス研究会. 松本. [2018. 8.24]
- Hasegawa M: α-Synuclein Propagation in Parkinson’s Disease and Multiple System Atrophy. Basic Science Summer School MDS/Education/Conferences & Courses. Osaka. [2018. 8. 3]
- 長谷川成人: 神経変性疾患における細胞内異常タンパク質のプリオン様伝播. 第41回日本神経科学会 教育講演. 神戸. [2018.7.27]
- 長谷川成人: 認知症の発症、進行の分子メカニズム. 日本大学 文理学部 講義. 東京. [2018.7. 25]
- Hasegawa M: αSynuclein in Parkinson’s disease and related disorders. WCP2018 KYOTO (18th World Congress of Basic and Clinical Pharmacology), Kyoto. [2018. 7. 5]
- Hasegawa M: Transmission of αSynuclein. 16th International Symposium on Amyloidosis (ISA2018), Kumamoto. [2018. 3. 28]
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