Project Leader
Hiroshi Sakuma
Our research focuses on autoimmune and inflammatory neurological diseases (AINDs) in childhood. They are significant social burden because of poor prognosis and high mortality. We have established a sustainable platform (a multicenter registry of patients and sample repository) for a prospective cohort studies on AINDs based on nationwide collaborative study. We perform multi-omics analysis of biomarkers including inflammatory mediators, microRNAs, and metabolites. This multifaceted approach using high-throughput methods enables us to explore novel molecular targets associated with AINDs.
Recent studies have highlighted the importance of glial cells in the pathogenesis of AINDs. Our transgenic animal models are expected to shed new light on how gilal cells contribute to the pathomechanisms of AINDs by regulating brain metabolism and inflammation, and also provide a rationale for a novel therapeutic strategy.