Backgrounds

Narcolepsy(NT1) and idiopathic hypersomnia(IH)are caused by abnormal regulation of intrinsic sleep-wake brain centers but the pathogenesis remain to be clarified. Hypersomnia patients shows cognitive dysfunction leading to severe impairment in daily/social life, but we only have inadequate symptomatic therapy. So underlying physiological/pathological sleep wake regulation in hypersomnia is necessary.

Objectives

• To elucidate the pathogenesis of sleep disorders that exhibit oversleeping and to develop new methods of diagnosis, prevention, and treatment
• To elucidate the successful foundation of substances that act to stabilize and maintain sleep and to develop new treatments
• To examine the foundation of arousal controls in cellular and animal models to clarify the conditions for healthy sleep

Members

Project Leader Taku Miyagawa

• Akiyo Natsubori
• Mihoko Shimada
• Yoshiki Matsuda