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Neural Prosthetics Project

Neural prosthetics for restoring lost functions

Project Leader Yukio Nishimura

Project Leader
Yukio Nishimura

Summary

Backgrounds

Paralysis following stroke and spinal cord injury is a leading cause of long-term disability. Most individuals who suffer a stroke or spinal cord injury, where their limb is paralysed but intact, have an intense desire to regain function of the impaired limb. Our research goal is to conceive innovative neuro-rehabilitation to restore lost functions after impairment of central nervous system, and to translate our findings into clinical applications capable of improving the quality of life for individual with neural damage.

Objectives

  • Restoring of sensory-motor function using a neural interface
  • Underlying psychological effects on functional recovery after neural damages

Members

Project Leader Yukio Nishimura

  • Yoshihisa Nakayama
  • Toshiki Tazoe
  • Osamu Yokoyama
  • Sho Sugawara
  • Michiaki Suzuki
  • Miki Kaneshige

Selected Publications

  • Kato K, Sasada S, and Nishimura Y. (2016) “Flexible adaptation to an artificial recurrent connection from muscle to peripheral nerve in man.” J. Neurophysiol. 115(2):978-991.
  • Sawada M, Kato K, Kunieda T, Mikuni N, Miyamoto S, Onoe H, Isa T, and Nishimura Y (2015) “Function of the nucleus accumbens in motor control during recovery after spinal cord injury.” Science. 350(6256):98-101.
  • Sasada S, Kato K, Kadowaki S, Groiss SJ, Ugawa Y, Komiyama T, and Nishimura Y. (2014) “Volitional walking via upper limb muscle-controlled stimulation of the lumbar locomotor center in man.” J. Neurosci. 34(33):11131-11142.
  • Nishimura Y, Perlmutter SI, Eaton RW, and Fetz EE. (2013) “Spike-timing-dependent plasticity in primate corticospinal connections induced during free behavior.” Neuron. 80(5):1301-1309.
  • Nishimura Y, Perlmutter SI, and Fetz EE. (2013) “Restoration of upper limb movement via artificial corticospinal and musculospinal connections in a monkey with spinal cord injury.” Front. Neural Circuits. 7:57.
  • Nishimura Y, Morichika Y, and Isa T. (2009) “A subcortical oscillatory network contributes to recovery of hand dexterity after spinal cord injury.” Brain. 132(Pt 3):709-721
  • Nishimura Y, Onoe H, Morichika Y, Perfiliev S, Tsukada H, and Isa T. (2007) “Time-dependent central compensatory mechanisms of finger dexterity after spinal cord injury.” Science. 318(5853):1150-1155.