• Child Brain Project

Child Brain Project

Translational research for child brain

Project Leader Hiroshi Sakuma

Project Leader
Hiroshi Sakuma

Hiroshi Sakuma has been the leader of the Child Brain Project since 2015. He graduated and obtained his MD (1993) and PhD (2005) degrees at Tokyo Medical and Dental University and pursued training in pediatric neurology at the National Center of Neurology and Psychiatry. He started his research activities on neuroimmunology in National Institute of Neuroscience under the supervision of Prof. Sachiko Miyake in 2010, and also was involved in the Health Labour Sciences Research on virus-associated acute encephalopathy since 2010. He has been working at Tokyo Metropolitan Institute of Medical Science since 2012. His current research interests include 1) pathomechanisms of virus-associated acute encephalopathies including febrile infection-related epilepsy syndrome, 2) biomarkers for pediatric immune-mediated neurological diseases, and 3) making international consensus on pediatric autoimmune neurological diseases.


The brains of children are the site of a variety of activities carried out by non-neuronal glial cells as well as neurons not found in the brains of adult humans. Brain development requires that activities of these cells be controlled in a normal fashion.

This project, chiefly from the perspective of the immune system, aims to elucidate the mechanisms by which the brain’s environment is maintained during its development and the causes of pediatric brain diseases such as encephalitis, encephalopathy that result from their failure, in order to develop methods of prevention and treatment.


  • To elucidate the role of nerve immunities that govern neurons and glial cells to maintain the brain environment during the developmental phase
  • To elucidate the immune system and non-immune system networks that operate to maintain the brain environment in the children’s brains
  • To elucidate the onset mechanisms for children’s brain diseases such as encephalitis and encephalopathy with the aim of developing new methods of prevention and treatment


Project Leader Hiroshi Sakuma

  • Tadayuki Shimada
  • Mariko Kasai
  • Kuniko Kohyama