Backgrounds

Within our cells, organellar structures efficiently execute a myriad of biochemical reactions. Recent studies have revealed that the decline in organelle quality and/or the disruption of quality control mechanisms are significant factors contributing to aging and the onset of neurodegenerative diseases. This project aims to identify novel "organelle quality control mechanisms" and elucidate their detailed functions from both cell biological and physiological perspectives. By doing so, we aim to gain a fundamental understanding of the mechanisms by which homeostasis is maintained within living organisms. Furthermore, by elucidating the disease pathogenesis that result from the breakdown of intracellular quality control, we aim to contribute to the improvement of quality of life.

Objectives

• To discover and elucidate the mechanisms of novel molecular pathways that govern organelle quality control.
• To clarify the molecular pathogenesis of diseases caused by the disruption of intracellular quality control mechanisms.

Members

Project Leader Koji Yamano