We continue to recruit clinical cases suspected of hypersomnia (total >1000) with PSG-MSLT data and DNA sample. By omics analysis we identified fatty acid/metabolic abnormalities in NT1 and IH and global hypomethylation in NT1
We organized diagnostic 3-day sleep study system comprising of 24hPSG-PSG-MSLT and found 24hPSG is better test to detect IH patients.
Animal sleep study demonstrated that serotonergic stimulation increases intraneuronal ATP level during Wake by two pathways. We also identified persistent sleep dysregulation in animal with social defeat stress.