Achievements in 2025

We have focused our research on the concept of central innate immune memory induced by cardiac stress. Our work revealed that changes in the hematopoietic niche—such as altered phenotypes of bone marrow mesenchymal stromal cells and reduced sympathetic nervous activity—serve as key triggers of this immune memory. Building on these findings, We are now extending his research to elucidate how autonomic neural remodeling during heart failure orchestrates multi-organ immune dysregulation.

Publications

Papers I 2025

• J Sugita, et al. Cardiopulmonary neuro-immune reflex: From afferent stress signaling to peripheral myeloid memory. Journal of cardiology. 2025:S0914-5087(25)00217-5.
• E Hasumi, et al. Heart failure monitoring with a single‑lead electrocardiogram at home. International journal of cardiology. 2025:432:133203.
• Y Nakayama, K Fujiu. Innate immune memory in macrophage differentiation and cardiovascular diseases. Inflammation and regeneration. 2025:45(1):17
• K Awaji, et al. Impact of Fli1 deletion on B cell populations: A focus on age-associated B cells and transcriptional dynamics. Journal of dermatological science. 2025:117(2):19-29

Key papers

• Y Nakayama, et al. Heart failure promotes multimorbidity through innate immune memory. Science Immunology. 2024;9(95):eade3814.
• J Sugita, et al. Cardiac macrophages prevent sudden death during heart stress. Nature Communications. 2021;12(1):1910.
• Y Nakayama, et al. A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation. Proceedings of the National Academy of Sciences of the United States of America. 2020:117(25):14365-14375