JSNP Excellent Presentation Award for AsCNP 2023 賞を受賞
2023/11/07依存性薬物プロジェクトの森屋由紀研究員、興津雅人研修生が、日本神経精神薬理学会において、JSNP Excellent Presentation Award for AsCNP 2023 賞を受賞しました。
JSNP Excellent Presentation Award for AsCNP 2023 賞は、2023/9/22-24 に中国の西安で開催されたAsCNP 2023 ( 第8回 アジア神経精神薬理学会 ) において優れた研究成果並びに優秀な発表に対して、日本神経精神薬理学会から授与される賞です。
「Additive Effects of δ Opioid Receptor Activation and μ Opioid Receptor Knockout in Reducing Hopelessness」
*Yuki MORIYA1,2, Yoshiyuki Kasahara2,3,4, Masafumi Shimada2, Yasufumi Sakakibara2,5, Hideaki Fujii8, Hiroshi Nagase6, Soichiro Ide1, Kazutaka Ikeda1, Frank Scott Hall7, George R Uhl9, Ichiro Sora10,2
- Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science
- Department of Biological Psychiatry, Tohoku University Graduate School of Medicine
- Department of Maternal and Fetal Therapeutics, Tohoku University Graduate School of Medicine
- Department of Maternal and Child Healthcare Medical Science, Tohoku University Graduate School of Medicine
- Department of Neurogenetics, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA
- Laboratory of Medicinal Chemistry, School of Pharmacy, Kitasato University
- Departments of Neurology and Pharmacology, University of Maryland School of Medicine, and VA Maryland Healthcare System, Baltimore, MD, USA
- Department of Psychiatry, Kobe University Graduate School of Medicine
δオピオイド受容体(DOP)作動薬の効果に雌雄差があることを確認
ストレス耐性機能報告のあるμオピオイド受容体欠損（MOP-KO）マウスに、うつ病の治療薬として注目されている選択的DOP作動薬を投与し、DOPのストレス耐性機能が働くかどうかを検討した。 抗うつ薬に対する反応性の高さが知られている、尾懸垂試験と強制水泳試験を行った。 実験結果よりメスMOP-KOマウスでのみ、DOPの活性化とμオピオイド受容体（MOP）の欠損が相加的な効果を示した。 これらの研究結果は、オピオイド受容体をターゲットとする、これまでにない新しい機序を持った抗うつ薬の開発に繋がることが期待できる。
To investigate the independent roles of δ-opioid receptor (DOP) activation and μ-opioid receptor knockout (MOP-KO) in behavioral despair, as measured by the tail suspension test (TST) and forced swim test (FST), in mice. The findings suggest that the activation of DOP and the absence of MOP have additive effects in reducing measures of behavioral despair, as demonstrated in the FST and TST. This implies that DOP activation can influence despair-related behaviors independently of MOP.
Conflicts of Interest: The authors declare no conflicts of interest.
「Dopamine dysregulation syndrome-like behavior in bilateral dorsal striatum 6-hydroxydopamine lesioned Parkinson's disease model mice」
*Masato Okitsu1, 2, Masayo Fujita1, Kazushi Takahashi2, Kazutaka Ikeda1.
- Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
- Department of Neurology, Tokyo Metropolitan Neurological Hospital,Tokyo, Japan
