7th Congress of AsCNP2021 JSNP Excellent Presentation Award for AsCNP2021 を受賞


古田島浩子研究員が「Prenatal exposure of GABAA receptor inhibitor picrotoxin causes ASD-like behaviors and aberrant gene expression in mice」により、7th Congress of AsCNP2021において、JSNP Excellent Presentation Award for AsCNP2021を受賞しました。



Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that is characterized by deficits of social interaction, but the pathophysiology of ASD has not yet been thoroughly defined. In the present study, we focused on γ-aminobutyric acid (GABA) A receptor signaling which has a key role in the development of immature mouse brain and injected blocker of GABAA receptor in pregnant mice. We found that the offspring showed ASD-like behaviors and the odorant pathway is aberrant in these offspring. Our study provides a better understanding of the pathophysiology of ASD.