講演要旨
Circadian clocks regulate us, but how do we regulate the clock? Genetics, biochemistry and structural biology all point to a central role for the oddly named kinase, Casein Kinase 1 (CK1). First discovered in 1978, the CK1 family plays a part in diverse processes and diseases. Here, I will describe how CK1 was found to be a core circadian component, its multiple functions in the clock and the journey to understand how the CK1 phosphoswitch controls time.
- 参考文献：
- 1. reviewed in Narasimamurthy and Virshup, Mol Cell, 81: 1133 (2021)
- 2. Masuda et al., PNAS, 117: 10888 (2020)
- 3. Narasimamurthy et al., PNAS, 115: 5986 (2018)
- 4. Zhou et al, Mol Cell, 66: 77 (2015)