感染制御プロジェクト|インフルエンザ・デング熱及び肝疾患に対する予防と治療

  • 医学研ロゴ

Achievements

Achievements

2018年

  1. Masaaki Okamoto, Yoshimi Fukushima, Takahisa Kouwaki, Takuji Daito, Michinori Kohara, Hiroshi Kida, Hiroyuki, Oshiumi.
    MicroRNA-451a in extracellular, blood-resident vesicles attenuates macrophage and dendritic cell responses to influenza whole-virus vaccine.
    Journal of Biological Chemistry. 2018 Nov 30;293(48):18585-18600. doi: 10.1074/jbc.RA118.003862.
  2. Takashi Imada, Koji Moriya, Masahiko, Uchiyama, Mitsuhiro Hitotsuyanagi, Akiko Masuda, Shotaro Ayukawa, Yo-ichi Tagawa, Naoshi Dohmae, Michinori Kohara, Masayuki Yamamura, Daisuke Kiga.
    A highly bioactive Lys-deficient IFN leads to a site-specific di-PEGylated IFN with equivalent bioactivity to that of IFN-α2b.
    ACS Synthetic Biology. 2018 Nov 16;7(11):2537-2546. doi: 10.1021/acssynbio.8b00188.
  3. Liang Cheng , Qi Wang , Guangming Li, Riddhima Banga , Jianping Ma, Haisheng Yu, Fumihiko Yasui , Zheng Zhang , Giuseppe Pantaleo, Matthieu Perreau, Sandra Zurawski , Gerard Zurawski, Yves Levy, Lishan Su.
    TLR3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 reservoirs.
    Journal of Clinical Investigation. 2018 Oct 1;128(10):4387-4396. doi: 10.1172/JCI99005.
  4. Bouchra Kitab, Michinori Kohara, Kyoko Tsukiyama-Kohara.
    Experimental in vitro and in vivo systems for studying the innate immune response during dengue virus infections.
    Archives of Virology. 2018 163:1717–1726. doi.org/10.1007/s00705-018-3784-z.
  5. Hironori Nishitsuji, Keisuke Harada, Saneyuki Ujino, Jing Zhang, Michinori Kohara, Masaya Sugiyama, Masashi Mizokami, Kunitada Shimotohno.
    Investigating the hepatitis B virus life cycle using engineered reporter hepatitis B viruses. Cancer Science. 2018 Jan;109(1):241-249. doi: 10.1111/cas.13440.

2017年

  1. Kyoko Tsukiyama-Kohara and Michinori Kohara. Hepatitis C Virus: Viral Quasispecies and Genotypes. International Journal of Molecular Sciences Int J Mol Sci. 2017 Dec 22;19(1). pii: E23. doi: 10.3390/ijms19010023. Review.
  2. Ming Chen, Chie Aoki-Utsubo, Masanori Kameoka, Lin Deng, Yutaka Terada, Wataru Kamitani, Kei Sato, Yoshio Koyanagi, Makoto Hijikata, Keiko Shindo, Takeshi Noda, Michinori Kohara & Hak Hotta. Broad-spectrum antiviral agents: secreted phospholipase A2 targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane. Scientific Reports 2017 Nov 21;7(1):15931. doi: 10.1038/s41598-017-16130-w.
  3. Kiminori Kimura, Akemi Ikoma, Maki Shibakawa, Shinji Shimoda, Kenichi Harada, Masanao Saio, Jun Imamura, Yosuke Osawa, Masamichi Kimura, Koji Nishikawa, Tsunekazu Hishima, Takuji Okusaka, Satoshi Morita, Kazuaki Inoue, Tatsuya Kanto, Koji Todaka, Yoichi Nakanishi, Michinori Kohara and Masashi Mizokami. Safety, tolerability, and preliminary efficacy of the anti-fibrotic small molecule PRI-724, a CBP/b-catenin inhibitor, in patients with hepatitis C virus-related cirrhosis: A single-center, open-label, dose escalation phase 1 trial. EBioMedicine. Sep;23:79-87. doi: 10.1016/j.ebiom.2017.08.016.
  4. Yusuke Sato, Hideki Matsui, Naoki Yamamoto, Risa Sato, Tsubasa Munakata, Michinori Kohara, Hideyoshi Harashima. Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious treatment of chronic hepatitis B infections. Journal of Controlled Release 2017 Oct 3;266:216-225. doi: 10.1016/j.jconrel.2017.09.044.
  5. Yu Sakurai, Wataru Mizumura1, Manami Murata, Tomoya Hada, Shoshiro Yamamoto, Kenichiro Ito, Kazuhiro Iwasaki, Takayuki Katoh, Yuki Goto, Asako Takagi, Michinori Kohara, Hiroaki Suga, Hideyoshi Harashima. Efficient siRNA delivery by lipid nanoparticles modified with a non-standard macrocyclic peptide for EpCAM-targeting. Molecular Pharmaceutics 2017 2017 Oct 2;14(10):3290-3298. doi: 10.1021/acs.molpharmaceut.7b00362.
  6. Tomoko Fujiyuki, Ryo Horie, Misako Yoneda, Takeshi Kuraishi, Fumihiko Yasui, Hyun-jeong Kwon, Keisuke Munekata, Fusako Ikeda, Miho Hoshi, Yuri Kiso, Mio Omi, Hiroki Sato, Hiroshi Kida, Shosaku Hattori, Michinori Kohara, Chieko Kai. Efficacy of recombinant measles virus expressing highly pathogenic avian influenza virus (HPAIV) antigen against HPAIV infection in monkeys. Scientific Reports 2017 2017 Sep 20;7(1):12017. doi: 10.1038/s41598-017-08326-x.
  7. Kayesh Mohammad, Ezzikouri Sayeh, Takahiro Sanada, Haiying Chi, Yukiko Hayashi, Khadija Rebbani, Bouchra Kitab, Aya Matuu, Noriaki Miyoshi, Tsunekazu Hishima, Michinori Kohara*, and Kyoko Tsukiyama-Kohara*. Oxidative Stress and Immune Responses During Hepatitis C Virus Infection in Tupaia belangeri. Scientific Reports 2017 Aug 29;7(1):9848. doi: 10.1038/s41598-017-10329-7.
  8. Kayesh Mohammad Enamul Hoque, Sayeh Ezzikouric, Haiying Chib, Takahiro Sanada, Naoki Yamamoto, Bouchra Kitabb, Takumi Haraguchi, Rika Matsuyama, Chimène Nze, Nkoguea, Hitoshi Hatai, Noriaki Miyoshi, Shuko Murakami, Yasuhito Tanaka, Jun-ichiro, Takano, Yumiko Shiogama, Yasuhiro Yasutomi, Michinori Kohara, and Kyoko Tsukiyama-Kohara. Interferon- Response is Impaired by Hepatitis B Virus infection in Tupaia belangeri. Virus Research 2017 Jun 2;237:47-57. doi:10.1016/j.virusres.2017.05.013.
  9. Kayesh MEH, Kitab B, Sanada T, Hayasaka D, Morita K, Kohara M, Tsukiyama-Kohara K. Susceptibility and initial immune response of Tupaia belangeri cells to dengue virus infection. Infect Genet Evol. 2017 Apr 6;51:203-210. doi: 10.1016/j.meegid.2017.04.003.
  10. Yuko Tokunaga, Yosuke Osawa, Takahiro Ohtsuki, Yukiko Hayashi, Kenzaburo Yamaji, Daisuke Yamane, Mitsuko Hara, Keisuke Munekata, Kyoko Tsukiyama-Kohara, Tsunekazu Hishima, Soichi Kojima, Kiminori Kimura, and Michinori Kohara. Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model. Scientific Reports 2017 Mar 23;7(1):325. doi:10.1038/s41598-017-00282-w.
  11. Takahashi S, Sato N, Kikuchi J, Kakinuma H, Okawa J, Masuyama Y, Iwasa S, Irokawa H, Hwang GW, Naganuma A, Kohara M, Kuge S. Immature Core protein of hepatitis C virus induces an unfolded protein response through inhibition of ERAD-L in a yeast model system. Genes Cells. 2017 Feb;22(2):160-173. doi: 10.1111/gtc.12464